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  1. 3661
    “…The therapeutic effect was dependent on cytokine-induced senescence in malignant B cells. The proinflammatory cytokines interferon-γ (IFN-γ) and tumor necrosis factor (TNF) were necessary for the survival benefit as well as for senescence induction in the λ-MYC model. …”
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    Therapy of lymphoma by immune checkpoint inhibitors: the role of T cells, NK cells and cytokine-induced tumor senescence
  2. 3662
    “…Consequently, Klotho restrained cellular senescence. In HKC‐8 cells, Klotho significantly inhibited Wnt1‐ and Wnt9a‐induced mitochondrial injury, cellular senescence, and fibrotic lesions. …”
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    Klotho retards renal fibrosis through targeting mitochondrial dysfunction and cellular senescence in renal tubular cells
  3. 3663
    “…ROS levels in chondrocytes were examined using the fluorescent dye DCFH-DA. Cellular senescence was determined using senescence-associated-β-galactosidase staining. …”
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    Apremilast prevents IL-17-induced cellular senescence in ATDC5 chondrocytes mediated by SIRT1
  4. 3664
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    Senescence Is Associated With Elevated Intracellular Resting [Ca(2 +)] in Mice Skeletal Muscle Fibers. An in vivo Study
  5. 3665
    “…High mobility group box 1 (HMGB1) and stimulator of interferon genes (STING) are involved in senescence. However, their interactions in senescence have not been reported. …”
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    HMGB1 orchestrates STING-mediated senescence via TRIM30α modulation in cancer cells
  6. 3666
    “…Cellular senescence is characterized by an irreversible cell cycle arrest and a pro‐inflammatory senescence‐associated secretory phenotype (SASP), which is a major contributor to aging and age‐related diseases. …”
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    Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice
  7. 3667
    por Das, Undurti N.
    Publicado 2021
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    “Cell Membrane Theory of Senescence” and the Role of Bioactive Lipids in Aging, and Aging Associated Diseases and Their Therapeutic Implications
  8. 3668
    “…We found that FK866 markedly inhibited the senescent characteristics of hDPCs after exposure to H(2)O(2), as revealed by an increase in the number of senescence-associated β-galactosidase (SA-β-gal)-positive hDPCs and the upregulation of the p21 and p53 proteins, which acts as molecular indicators of cellular senescence. …”
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    FK866 Protects Human Dental Pulp Cells against Oxidative Stress-Induced Cellular Senescence
  9. 3669
    “…Loss of MKL1 was accompanied by reduced senescence/proinflammation in the vessel wall and cultured vascular smooth muscle cells (VSMCs). …”
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    MKL1 cooperates with p38MAPK to promote vascular senescence, inflammation, and abdominal aortic aneurysm
  10. 3670
    “…Leaf senescence is a highly complex genetic process that is finely tuned by multiple layers of regulation. …”
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    Transcription Factor NAC075 Delays Leaf Senescence by Deterring Reactive Oxygen Species Accumulation in Arabidopsis
  11. 3671
    “…Numerous environmental and endogenous signals control the highly orchestrated and intricate process of plant senescence. Ethylene, a well-known inducer of senescence, has long been considered a key endogenous regulator of leaf and flower senescence, but the molecular mechanism of ethylene-induced ovule senescence has not yet been elucidated. …”
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    PbEIL1 acts upstream of PbCysp1 to regulate ovule senescence in seedless pear
  12. 3672
    “…Thus, we suggest that β-catenin in NMRs functions to offset senescence by regulating cholesterol metabolism, which may contribute to increased longevity in NMRs.…”
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    β-catenin-promoted cholesterol metabolism protects against cellular senescence in naked mole-rat cells
  13. 3673
    “…KEY MESSAGE: This study showed the systematic identification of long non-coding RNAs (lncRNAs) involving in flag leaf senescence of rice, providing the possible lncRNA-mRNA regulatory relationships and lncRNA-miRNA-mRNA ceRNA networks during leaf senescence. …”
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    Genome-wide identification and characterization of long non-coding RNAs involved in flag leaf senescence of rice
  14. 3674
    “…Here, we show that GC treatment in young mice induces vascular endothelial cell senescence in metaphysis of long bone, and that inhibition of endothelial cell senescence improves GC-impaired bone angiogenesis with coupled osteogenesis. …”
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    Osteoclasts protect bone blood vessels against senescence through the angiogenin/plexin-B2 axis
  15. 3675
    “…As such, we studied 87 individuals, 62 newly diagnosed and untreated leprosy patients distributed according to the age range and to the clinical forms of the disease and 25 healthy volunteers, who were studied as controls. The frequency of senescent and memory CD8(+) leukocytes was assessed by immunofluorescence of biopsies from cutaneous lesions, while the serum levels of IgG anti-CMV antibodies were analyzed by chemiluminescence and the gene expression of T cell receptors' inhibitors by RT-qPCR. …”
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    Presence of Senescent and Memory CD8+ Leukocytes as Immunocenescence Markers in Skin Lesions of Elderly Leprosy Patients
  16. 3676
    “…Aldosterone exerts an enormous function on proximal tubular cells (PTC) senescence, which is a common pathomechanism contributing to renal dysfunction. …”
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    Autophagosome protects proximal tubular cells from aldosterone-induced senescence through improving oxidative stress
  17. 3677
    “…Similarly, cellular senescence (hereon referred to simply as “senescence”) now is recognized as a complex stress response that culminates with a change in cell fate. …”
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    The Cellular Senescence Stress Response in Post-Mitotic Brain Cells: Cell Survival at the Expense of Tissue Degeneration
  18. 3678
    “…Here, we have shown that NMN (an NAD(+) precursor) administration could significantly reduce tubular cell DNA damage and subsequent cellular senescence induced by hydrogen peroxide and hypoxia in human proximal tubular cells (HK-2 cells). …”
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    Nicotinamide Mononucleotide Attenuates Renal Interstitial Fibrosis After AKI by Suppressing Tubular DNA Damage and Senescence
  19. 3679
    “…Stable overexpression of miR-216a induced a premature senescent-like phenotype, whereas the senescent features and increased activity of senescence-associated β-galactosidase (SA-β-gal) were reversed after Rb2 treatment. …”
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    Inhibitory role of ginsenoside Rb2 in endothelial senescence and inflammation mediated by microRNA-216a
  20. 3680
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    Author Correction: Senescence of song revealed by a long-term study of the Seychelles warbler (Acrocephalus sechellensis)
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