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  1. 3861
    “…In addition, both repression of PKCδ expression and inhibition of PKCδ activity induced cellular senescence‐like phenotypes, including increased senescence‐associated β‐galactosidase (SA‐β‐gal) staining, low LaminB1 expression, large nucleus size, and senescence‐associated secretory phenotype (SASP) detection. …”
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    Inhibition of protein kinase C delta leads to cellular senescence to induce anti‐tumor effects in colorectal cancer
  2. 3862
    por Datta, Ishwaree, Bangi, Erdem
    Publicado 2023
    “…The highly heterogeneous, dynamic, and context-dependent nature of senescence-associated features and the relatively small numbers of senescent cells in tissues makes in vivo mechanistic studies of senescence challenging. …”
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    Senescent cells and macrophages cooperate through a multi-kinase signaling network to promote intestinal transformation in Drosophila
  3. 3863
    por Kuai, Zheng, Hu, Yu
    Publicado 2023
    “…A series of crucial common senescence genes were found. The senescence gene expression profile hints at an intriguing connection between monocytes and HF. …”
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    Integration single-cell and bulk RNA-sequencing data to reveal senescence gene expression profiles in heart failure
  4. 3864
    “…Cellular senescence is linked to a wide range of age‐related diseases and can be triggered by a variety of stresses, including DNA damage. …”
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    DNA damage‐induced cellular senescence is regulated by 53BP1 accumulation in the nuclear foci and phase separation
  5. 3865
    por Li, Zhao-Cheng., An, Fu.
    Publicado 2023
    “…In this study, we explored the role of senescence-related genes (SR-DEGs) and its underlying mechanism in IDD. …”
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    ERBB2-PTGS2 axis promotes intervertebral disc degeneration by regulating senescence of nucleus pulposus cells
  6. 3866
    “…Western blot analysis revealed Ezh2-deficient stromal cells have reduced amounts of the histone methylation mark H3K27me3, causing upregulation of senescence markers p21 and p16 and indicating that enhanced stromal cell senescence likely impairs decidualization. …”
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    Uterine-specific Ezh2 deletion enhances stromal cell senescence and impairs placentation, resulting in pregnancy loss
  7. 3867
    “…A key biological process in establishing and maintaining senescence is oxidative stress, which is present in multiple cellular compartments of steatotic hepatocytes. …”
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    The Role of Oxidative Stress and Cellular Senescence in the Pathogenesis of Metabolic Associated Fatty Liver Disease and Related Hepatocellular Carcinoma
  8. 3868
    “…Here, we screened for three inbred lines (PH4CV, B73, and SH19B) that showed differentially senescing phenotypes under heat stress. Among them, PH4CV showed no obviously senescing phenotype under heat stress, while SH19B demonstrated a severely senescing phenotype, with B73 being between the two extremes. …”
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    Transcriptomic Analysis of Three Differentially Senescing Maize (Zea mays L.) Inbred Lines upon Heat Stress
  9. 3869
    “…We obtained cellular senescence-related pathways from the Molecular Signatures Database and evaluated the activity of senescence pathways in DKD patients using the Gene Set Enrichment Analysis (GSEA) algorithm. …”
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    Identification and analysis of cellular senescence-associated signatures in diabetic kidney disease by integrated bioinformatics analysis and machine learning
  10. 3870
    “…The as-prepared MNPs significantly decrease senescence-associated B-Gal enzymatic activity in ADSCs but not in Fb. …”
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    Magnetic Nanoparticle Coating Decreases the Senescence and Increases the Targeting Potential of Fibroblasts and Adipose-Derived Mesenchymal Stem Cells
  11. 3871
    “…The success of chemotherapy and radiotherapy anti-cancer treatments can result in tumor suppression or senescence induction. Senescence was previously considered a favorable therapeutic outcome, until recent advancements in oncology research evidenced senescence as one of the culprits of cancer recurrence. …”
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    Deep ensemble learning and transfer learning methods for classification of senescent cells from nonlinear optical microscopy images
  12. 3872
    “…However, acquired resistance is generally inevitable, the mechanisms of which are not fully understood. Cell senescence and senescence-associated secretory phenotype (SASP) are involved in extensive biological functions. …”
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    Vemurafenib induces a noncanonical senescence-associated secretory phenotype in melanoma cells which promotes vemurafenib resistance
  13. 3873
    “…Similar modulation is observed when the ventricular fibroblasts are co-cultured with AC16 cells under baseline and induced senescence conditions. Given that the response to TGF-β stimulation is commonly measured to study fibrotic signaling and drug treatments in vitro, the results here suggest that the effect of cellular crosstalk should be more broadly considered.…”
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    Co-culture with normal and senescent AC16 cardiomyocytes modulates fibrotic response in primary human ventricular fibroblasts
  14. 3874
    “…Perturbed metabolism of ammonia, an endogenous cytotoxin, causes mitochondrial dysfunction, reduced NAD(+)/NADH (redox) ratio, and postmitotic senescence. Sirtuins are NAD(+)‐dependent deacetylases that delay senescence. …”
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    Dysregulated cellular redox status during hyperammonemia causes mitochondrial dysfunction and senescence by inhibiting sirtuin‐mediated deacetylation
  15. 3875
    “…CONCLUSIONS: Overall, our findings point to the crucial treatment effect of Arte on inflammation, intestinal cell senescence, and CRC cell proliferation and offer a new option for CRC treatment.…”
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    Artesunate alleviates 5-fluorouracil-induced intestinal damage by suppressing cellular senescence and enhances its antitumor activity
  16. 3876
    “…The findings revealed that NMN and CoQ10 reduced H(2)O(2)-induced senescence and increased hUC-MSCs’ proliferation in the late phase as passage 12 and later. …”
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    Antioxidants Improve the Proliferation and Efficacy of hUC-MSCs against H(2)O(2)-Induced Senescence
  17. 3877
    por Mirzayans, Razmik, Murray, David
    Publicado 2023
    “…Such cells with a highly enlarged nucleus, multiple nuclei, and/or multiple micronuclei are often referred to as polyploid giant cancer cells (PGCCs), and may exhibit features of senescence. PGCCs may enter a dormant phase (active sleep) after they are formed, but a subset remain viable, secrete growth promoting factors, and can give rise to therapy resistant and tumor repopulating progeny. …”
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    Intratumor Heterogeneity and Treatment Resistance of Solid Tumors with a Focus on Polyploid/Senescent Giant Cancer Cells (PGCCs)
  18. 3878
    “…Background: Senescence, a characteristic of cellular aging and inflammation, has been linked to the acceleration of osteoarthritis. …”
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    A Systemic and Local Comparison of Senescence in an Acute Anterior Cruciate Ligament Injury—A Pilot Case Series
  19. 3879
    “…According to our oncogene-induced model for cancer development, senescence is a major tumor progression barrier. However, whether senescence is implicated in the progression of early-stage androgen-sensitive to highly aggressive castration-resistant prostate cancer (CRPC) remains poorly addressed. …”
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    A GATA2-CDC6 axis modulates androgen receptor blockade-induced senescence in prostate cancer
  20. 3880
    “…AIMS: Vascular senescence, which is closely related to epigenetic regulation, is an early pathological condition in cardiovascular diseases including atherosclerosis. …”
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    Epigenetic modulation of Drp1-mediated mitochondrial fission by inhibition of S-adenosylhomocysteine hydrolase promotes vascular senescence and atherosclerosis
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