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  1. 3901
    “…It is not clear which type of genomic lesions induces senescence, but it is known that UV irradiation can activate cellular senescence in photoaged skin. …”
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    UV-induced G4 DNA structures recruit ZRF1 which prevents UV-induced senescence
  2. 3902
    “…OBJECTIVE: To explore the mechanism of psoralen synergized with exosomes (exos)-loaded SPC25 on nucleus pulposus (NP) cell senescence in intervertebral disc degeneration (IVDD). …”
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    Psoralen synergizes with exosome-loaded SPC25 to alleviate senescence of nucleus pulposus cells in intervertebral disc degeneration
  3. 3903
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    Corrigendum: The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells
  4. 3904
    “…Our protocol serves as a methodological resource for investigating transcriptomic m(6)A alterations in cellular senescence as well as a valuable paradigm for the validation of genes of interest.…”
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    An experimental workflow for identifying RNA m(6)A alterations in cellular senescence by methylated RNA immunoprecipitation sequencing
  5. 3905
    “…Cells from these patients offer an opportunity to study telomere-related aging and senescence. Our previous work has found that telomere shortening stimulates DNA damage responses (DDRs) and increases reactive oxygen species (ROS), thereby promoting entry into senescence. …”
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    CRISPR screen identifies CEBPB as contributor to dyskeratosis congenita fibroblast senescence via augmented inflammatory gene response
  6. 3906
    “…Here again, these two profiles were characterized by a low level of T4 and T8 cell activation and senescence. CONCLUSION: Our observation of low circulating levels of activated and senescent T cells in HIV-1 patients with NCI raises the interesting hypothesis that these lymphocytes may be recruited into the central nervous system.…”
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    Low levels of peripheral blood activated and senescent T cells characterize people with HIV-1-associated neurocognitive disorders
  7. 3907
    “…METHODS: We explored the role of Ribonucleotide reductase subunit M2 (RRM2), a gene associated with senescence, in the sensitivity of prostate cancer to docetaxel. …”
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    The key cellular senescence related molecule RRM2 regulates prostate cancer progression and resistance to docetaxel treatment
  8. 3908
    “…Evidence indicates that iron overload may induce senescence in cultured cell lines. Importantly, cells derived from female human and mice generally show enhanced senescence‐associated phenotype, compared with males. …”
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    Iron overload induces cerebral endothelial senescence in aged mice and in primary culture in a sex‐dependent manner
  9. 3909
    “…BACKGROUND: Cellular senescence is defined as an irreversible cell cycle arrest caused by various internal and external insults. …”
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    Senescent tumor cells in colorectal cancer are characterized by elevated enzymatic activity of complexes 1 and 2 in oxidative phosphorylation
  10. 3910
    “…By combining the PARP inhibitor (PARPi), talazoparib, with radiation, senescence was enhanced in 4T1 and MDA-MB-231 triple-negative breast cancer cell lines (based on SA-β-gal upregulation, increased expression of CDKN1A and the senescence-associated secretory phenotype (SASP) marker, IL6). …”
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    The Combination of Radiation with PARP Inhibition Enhances Senescence and Sensitivity to the Senolytic, Navitoclax, in Triple Negative Breast Tumor Cells
  11. 3911
    “…The growth of normal SHE cells was controlled by their division, death, and senescence rates, and all senescent cells were converted from normal cells. …”
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    A biologically based model of growth and senescence of Syrian hamster embryo (SHE) cells after exposure to arsenic.
  12. 3912
    “…We report the comprehensive investigation of SARS vaccine efficacy in young and senescent mice following homologous and heterologous challenge. …”
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    Vaccine Efficacy in Senescent Mice Challenged with Recombinant SARS-CoV Bearing Epidemic and Zoonotic Spike Variants
  13. 3913
    “…BACKGROUND: p16 (INK4a) tumor suppressor protein has been widely proposed to mediate entrance of the cells into the senescent stage. Promoter of p16 (INK4a) gene contains at least five putative GC boxes, named GC-I to V, respectively. …”
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    Sp1 Is Essential for p16(INK4a) Expression in Human Diploid Fibroblasts during Senescence
  14. 3914
    Publicado 1981
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    Status of mitochondria in living human fibroblasts during growth and senescence in vitro: use of the laser dye rhodamine 123
  15. 3915
    Publicado 1985
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    Rapid disappearance of statin, a nonproliferating and senescent cell- specific protein, upon reentering the process of cell cycling
  16. 3916
    Publicado 1981
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    Aging and antimicrobial immunity. Impaired production of mediator T cells as a basis for the decreased resistance of senescent mice to listeriosis
  17. 3917
    por Keller, L.F, Reid, J.M, Arcese, P
    Publicado 2008
    “…Mutation accumulation (MA) and antagonistic pleiotropy (AP) have each been hypothesized to explain the evolution of ‘senescence’ or deteriorating fitness in old age. These hypotheses make contrasting predictions concerning age dependence in inbreeding depression in traits that show senescence. …”
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    Testing evolutionary models of senescence in a natural population: age and inbreeding effects on fitness components in song sparrows
  18. 3918
    “…These results reveal that loss of miRNA biogenesis activates a DNA damage checkpoint, up-regulates p19(Arf)-p53 signaling, and induces senescence in primary cells.…”
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    Loss of miRNA biogenesis induces p19(Arf)-p53 signaling and senescence in primary cells
  19. 3919
    “…This senescence-associated secretory phenotype (SASP) developed slowly over several days and only after DNA damage of sufficient magnitude to induce senescence. …”
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    Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
  20. 3920
    “…Fibroblasts derived from glucose-6-phosphate dehydrogenase (G6PD)-deficient patients display retarded growth and accelerated cellular senescence that is attributable to increased accumulation of oxidative DNA damage and increased sensitivity to oxidant-induced senescence, but not to accelerated telomere attrition. …”
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    Telomerase prevents accelerated senescence in glucose-6-phosphate dehydrogenase (G6PD)-deficient human fibroblasts
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