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381por Paudel, Bimal, Das, Aayudh, Tran, Michaellong, Boe, Arvid, Palmer, Nathan A., Sarath, Gautam, Gonzalez-Hernandez, Jose L., Rushton, Paul J., Rohila, Jai S.“…Senescence in biofuel grasses is a critical issue because early senescence decreases potential biomass production by limiting aerial growth and development. 2-Dimensional, differential in-gel electrophoresis (2D-DIGE) followed by mass spectrometry of selected protein spots was used to evaluate differences between leaf proteomes of early (ES)- and late- senescing (LS) genotypes of Prairie cordgrass (ES/LS PCG) and switchgrass (ES/LS SG), just before and after senescence was initiated. …”
Publicado 2016
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382por Fessler, Johannes, Raicht, Andrea, Husic, Rusmir, Ficjan, Anja, Duftner, Christina, Schwinger, Wolfgang, Dejaco, Christian, Schirmer, Michael“…OBJECTIVE: To investigate the possible occurrence of early thymic failure and premature senescence of naïve and memory T-cells in patients with axial spondyloarthritis (aSpA). …”
Publicado 2016
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383“…Leaf senescence is a complicated developmental process that involves degenerative changes and nutrient recycling. …”
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384por Altieri, Paola, Barisione, Chiara, Lazzarini, Edoardo, Garuti, Anna, Bezante, Gian Paolo, Canepa, Marco, Spallarossa, Paolo, Tocchetti, Carlo Gabriele, Bollini, Sveva, Brunelli, Claudio, Ameri, Pietro“…Testosterone, but not 17β‐estradiol, counteracted doxorubicin‐elicited senescence. Downregulation of telomere binding factor 2, which has been pinpointed previously as being pivotal to doxorubicin‐induced senescence, was also prevented by testosterone, as were p53 phosphorylation and accumulation. …”
Publicado 2016
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385“…A confounding aspect of biological ageing is the nature and role of senescent cells. It is unclear whether the three major types of cellular senescence, namely replicative senescence, oncogene-induced senescence and DNA damage-induced senescence are descriptions of the same phenomenon instigated by different sources, or if each of these is distinct, and how they are associated with ageing. …”
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386“…Senescence is defined as a stable cell growth arrest. …”
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388por Urbanelli, Lorena, Buratta, Sandra, Sagini, Krizia, Tancini, Brunella, Emiliani, Carla“…Cell senescence is associated with the secretion of many factors, the so-called “senescence-associated secretory phenotype”, which may alter tissue microenvironment, stimulating the organism to clean up senescent cells and replace them with newly divided ones. …”
Publicado 2016
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389“…SA-β-gal staining indicated that DXM increased cell senescence. Notably, DXM-induced cell senescence was exacerbated by the autophagic inhibitor 3-MA. …”
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390por Labay, Edwardine, Mauceri, Helena J., Efimova, Elena V., Flor, Amy C., Sutton, Harold G., Kron, Stephen J., Weichselbaum, Ralph R.Enlace del recurso
Publicado 2016
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391“…Induction of replicative senescence in cells was validated by positive senescence-associated β-galactosidase staining. …”
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392“…While many theories exist to explain the aging process, the production of reactive oxygen species (ROS) provides a signaling link between engagement of cellular senescence and several age-associated pathologies. Cellular senescence has evolved to restrict tumor progression but the accompanying senescence-associated secretory phenotype (SASP) promotes pathogenic pathways. …”
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393por Sobieszczuk-Nowicka, E.“…Leaf senescence is a terminal step in plant growth and development. …”
Publicado 2016
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394por Schafer, Marissa J., White, Thomas A., Iijima, Koji, Haak, Andrew J., Ligresti, Giovanni, Atkinson, Elizabeth J., Oberg, Ann L., Birch, Jodie, Salmonowicz, Hanna, Zhu, Yi, Mazula, Daniel L., Brooks, Robert W., Fuhrmann-Stroissnigg, Heike, Pirtskhalava, Tamar, Prakash, Y. S., Tchkonia, Tamara, Robbins, Paul D., Aubry, Marie Christine, Passos, João F., Kirkland, James L., Tschumperlin, Daniel J., Kita, Hirohito, LeBrasseur, Nathan K.“…Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by interstitial remodelling, leading to compromised lung function. Cellular senescence markers are detectable within IPF lung tissue and senescent cell deletion rejuvenates pulmonary health in aged mice. …”
Publicado 2017
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395“…ARF is a key regulator of cellular senescence, an irreversible cell growth arrest that suppresses tumor cell growth. …”
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396por Ghanam, A.R., Xu, Qianlan, Ke, Shengwei, Azhar, Muhammad, Cheng, Qingyu, Song, Xiaoyuan“…Cellular senescence can be described as a complex stress response that leads to irreversible cell cycle arrest. …”
Publicado 2017
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397por Baker, Darren J., Alimirah, Fatouma, van Deursen, Jan M., Campisi, Judith, Hildesheim, Jeffrey“…Cellular senescence is defined as an irreversible growth arrest with the acquisition of a distinctive secretome. …”
Publicado 2017
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398por Möttönen, Mikko J., Ukkola, Olavi, Lumme, Jarmo, Kesäniemi, Y. Antero, Huikuri, Heikki V., Perkiömäki, Juha S.“…Conclusion: Aging from middle age to senescence increases the echocardiographic indexes of LVMI, LVPW thickness, FS and LAD. …”
Publicado 2017
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399por Demaria, Marco“…Many genotoxic chemotherapies have debilitating side effects and induce cellular senescence in normal tissues. Senescent cells acquire a pro-inflammatory phenotype which contributes to local and systemic inflammation. …”
Publicado 2017
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400por Villiard, Éric, Denis, Jean-François, Hashemi, Faranak Sadat, Igelmann, Sebastian, Ferbeyre, Gerardo, Roy, Stéphane“…Senescence represents a mechanism to avoid undesired cell proliferation that plays a role in tumor suppression, wound healing and embryonic development. …”
Publicado 2017
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