“…These results demonstrate that the direct role of p53-mediated cell cycle arrest, senescence and apoptosis is to control genomic stability in vivo. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…MATERIAL AND METHODS: Cellular senescence was evaluated using β-galactosidase staining of preadipocytes obtained from a homozygous c.985C>T patient. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…However, fluorescent Chl catabolites accumulate in some senescent leaves and in peels of ripe bananas and induce a striking blue glow. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Maize exhibits a wide range of heterotic traits, but the molecular basis of heterosis at the reproductive stage has seldom been exploited. Leaf senescence is a degenerative process which affects crop yield and quality. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…However, it remains blurred whether, in the AD brains, Aβ accelerates the neuronal senescence and whether this senescence, in turn, impairs the cognitive function. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Senescent cells secrete senescence-associated secretory phenotype (SASP) proteins to carry out several functions, such as sensitizing surrounding cells to senesce; immunomodulation; impairing or fostering cancer growth; and promoting tissue development. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In this study, we identified lncRNAs in a 7-month-old mouse brain through deep RNA sequencing using the senescence-accelerated mouse prone 8 (SAMP8) and senescence-accelerated mouse resistant 1 (SAMR1) models. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This study aimed to establish a longterm culture of WT cells to enable the study of molecular events to attempt to explain its cellular senescence. Methods: Primary cell cultures from fresh WT tumor specimen were established. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We found Cr(VI) induced premature senescence in L-02 hepatocytes, as confirmed by increase in senescence associated-β-galactosidase (SA-β-Gal) activity. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We show that HOTAIR regulates activation of NF-κB by decreasing Iκ-Bα (NF-κB inhibitor) and establish that by inducing prolonged NF-κB activation and expression of NF-κB target genes during DNA damage, HOTAIR plays a critical role in cellular senescence and platinum sensitivity. Our findings suggest that a NF-κB-HOTAIR axis drives a positive-feedback loop cascade during DNA damage response and contributes to cellular senescence and chemotherapy resistance in ovarian and other cancers.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In contrast, cellular senescence inhibits HSCs’ activity and limits fibrosis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CD47 signaling in endothelial cells has been shown to suppress angiogenesis, but little is known about the link between CD47 and endothelial senescence. Herein, we demonstrate that the thrombospondin-1 (TSP1)-CD47 signaling pathway is a major mechanism for driving endothelial cell senescence. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The addition of conditioned medium collected from rat AECs to lipopolysaccharide-activated macrophages elicited anti-inflammatory properties through a decrease of Tnfa expression and slowed tumor cell proliferation in vitro and in vivo. The senescence-associated secretory phenotype was also significantly lower upon incubation of senescent human IMR-90 fibroblast cells with conditioned medium from rat AECs. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Cellular senescence occurs by proliferative exhaustion (PEsen) or following multiple cellular stresses but had not previously been subject to detailed metabolomic analysis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Taken together, these results indicate that DLX3 mutations act as a loss of function in senescence. The delayed senescence of BMSCs leads to increased bone formation by compensating decreased osteogenic potentials with more generations and extended functional lifespan. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Further study showed that ENDO2 subcellular localization is essentially cytoplasmic (endoplasmic reticulum-associated) in healthy cells, but often localized to the nucleus and in senescing/dying cells it was associated with fragmented nuclei. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Treatment of LN229 cells with asialofetuin (ASF), attenuated their uptake of labeled fetuin‐A, and induced senescence in them. Interestingly, the D subclone that had ~90% reduction in ectopic fetuin‐A, underwent senescence in serum‐free medium which was blunted in the presence of purified fetuin‐A. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Leaf senescence is a complex biological process and defense responses play vital role for rice development, their molecular mechanisms, however, remain elusive in rice. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Cellular senescence is classified into two groups: replicative and premature senescence. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso