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  1. 4041
    “…In this study, we constructed two doxycycline-inducing KLF4 cell models, and demonstrated overexpression of KLF4 could promote cell senescence, detected by senescence-associated β-galactosidase activity assay. …”
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    Overexpression of KLF4 promotes cell senescence through microRNA-203-survivin-p21 pathway
  2. 4042
    “…Standard-of-care chemo- or radio-therapy can induce, besides tumor cell death, also tumor cell senescence. While senescence is considered to be a principal barrier against tumorigenesis, senescent cells can survive in the organism for protracted periods of time and they can promote tumor development. …”
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    Tumor growth accelerated by chemotherapy-induced senescent cells is suppressed by treatment with IL-12 producing cellular vaccines
  3. 4043
    “…We administered Tiantai No. 1 intragastrically to senescence-accelerated mouse prone 8 (SAMP8) mice (a model of Alzheimer's disease) at doses of 50, 100 or 150 mg/kg per day for 8 weeks and evaluated their behavior in the Morris water maze and expression of Alzheimer's disease-related proteins in the brain. …”
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    Neuroprotective effect of the Chinese medicine Tiantai No. 1 and its molecular mechanism in the senescence-accelerated mouse prone 8
  4. 4044
    “…Human DIRAS3 KD ASCs develop also a senescence phenotype in sWAT of SCID mice. Finally, we show that DIRAS3 KD in ASCs stimulates both adipogenic differentiation and premature senescence. …”
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    Silencing of the small GTPase DIRAS3 induces cellular senescence in human white adipose stromal/progenitor cells
  5. 4045
    “…Mitochondrial DNA methylation was examined during the period of senescence. Results. Senescent MSCs exhibited flattened and enlarged morphology and were positive for the senescence-associated beta-galactosidase (SA-β-Gal). …”
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    Mitochondrial DNA Hypomethylation Is a Biomarker Associated with Induced Senescence in Human Fetal Heart Mesenchymal Stem Cells
  6. 4046
    “…However, how miR-135a is involved in the calcification in senescent vascular smooth muscle cells (VSMCs) is not clear yet. …”
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    miR-135a Suppresses Calcification in Senescent VSMCs by Regulating KLF4/STAT3 Pathway
  7. 4047
    “…ASP treatment prevents HSC/HPCs senescence with decreased AGEs levels in the serum, reduced SA-β-Gal positive cells, and promoted CFU-Mix formation in the D-gal administrated mouse. …”
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    Angelica Sinensis Polysaccharide Prevents Hematopoietic Stem Cells Senescence in D-Galactose-Induced Aging Mouse Model
  8. 4048
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    MicroRNA-146a-5p Limits Elevated TGF-β Signal during Cell Senescence
  9. 4049
    “…Cellular senescence is associated with aging and is considered a potential contributor to age-associated neurodegenerative disease. …”
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    Ionizing radiation reduces ADAM10 expression in brain microvascular endothelial cells undergoing stress-induced senescence
  10. 4050
    “…No evidence of accelerated leaf necrosis or up‐regulation of senescence gene markers was apparent in these seedlings, suggesting senescence is not required for Lr34 resistance, although leaf tip necrosis occurred in mature plant flag leaves. …”
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    The Lr34 adult plant rust resistance gene provides seedling resistance in durum wheat without senescence
  11. 4051
    “…Besides, the expression of NOLC1 was negatively correlated with CSIG in the aged mouse tissue and replicative senescent 2BS cells, and the down‐regulation of NOLC1 could rescue CSIG knockdown‐induced 2BS senescence. …”
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    Enhanced NOLC1 promotes cell senescence and represses hepatocellular carcinoma cell proliferation by disturbing the organization of nucleolus
  12. 4052
    “…Silencing of SUSD2 using siRNA resulted in senescence and cell death of Ishikawa cells via activation of SMAD2/3. …”
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    Downregulation of endometrial mesenchymal marker SUSD2 causes cell senescence and cell death in endometrial carcinoma cells
  13. 4053
    “…Emerging evidence suggests that cell senescence plays an important role in aging‐associated diseases including neurodegenerative diseases. …”
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    HIV and drug abuse mediate astrocyte senescence in a β‐catenin‐dependent manner leading to neuronal toxicity
  14. 4054
    “…On acquisition of an oncogenic mutation, primary human and mouse cells can enter oncogene-induced senescence (OIS). OIS is characterized by a stable proliferation arrest and secretion of proinflammatory cytokines and chemokines, the senescence-associated secretory phenotype. …”
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    Oncogene-Expressing Senescent Melanocytes Up-Regulate MHC Class II, a Candidate Melanoma Suppressor Function
  15. 4055
    “…Senescent stromal cells support the development of prostate cancer and are considered potential therapeutic targets. …”
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    Ginsenoside Rg3 inhibits the senescence of prostate stromal cells through down-regulation of interleukin 8 expression
  16. 4056
    “…There are multiple competing hypotheses for this process, perhaps the most commonly cited is that senescent RBCs expose neoantigens [or senescent antigen(s)] that are then recognized by naturally occurring antibodies, which opsonize the senescent cells and result in clearance from circulation. …”
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    Antibodies to Senescent Antigen and C3 Are Not Required for Normal Red Blood Cell Lifespan in a Murine Model
  17. 4057
    “…Senescent-like cardiomyocytes were more resistant to CCCP-induced mitochondrial depolarization, which was accompanied by suppressed expression of parkin, PINK1, and LC3-II. …”
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    Resveratrol Ameliorates Mitochondrial Elongation via Drp1/Parkin/PINK1 Signaling in Senescent-Like Cardiomyocytes
  18. 4058
    por Chen, Jing, Kastan, Michael B.
    Publicado 2017
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    A novel DNA damage-induced alternative splicing pathway that regulates p53 and cellular senescence markers
  19. 4059
    “…Aging increases cellular senescence, which is manifested as an increase in SA-β-gal-positive cells, increased mitochondrial-specific reactive oxygen species (ROS) production, and the expression of p21 in the elderly. …”
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    Adipose-Derived Mesenchymal Stem Cells from the Elderly Exhibit Decreased Migration and Differentiation Abilities with Senescent Properties
  20. 4060
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    Magnifying the Senescence: Impact of Oral Health on Quality of Life and Daily Performance in Geriatrics: A Cross-Sectional Study
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