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  1. 4081
    “…This report examines whether COPD may cause a senescence response in human bronchial epithelial cells (HBECs), leading to the progression of LC in a senescence-dependent manner. …”
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    Serum from patients with chronic obstructive pulmonary disease induces senescence-related phenotype in bronchial epithelial cells
  2. 4082
    “…Age-dependent senescence is a multifaceted and highly coordinated developmental phase in the life of plants that is manifested with genetic, biochemical and phenotypic continuum. …”
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    Dynamic modeling of transcriptional gene regulatory network uncovers distinct pathways during the onset of Arabidopsis leaf senescence
  3. 4083
    “…Premature senescence greatly affects the yield production and the grain quality in plants, although the molecular mechanisms are largely unknown. …”
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    Genetic and Physio-Biochemical Characterization of a Novel Premature Senescence Leaf Mutant in Rice (Oryza sativa L.)
  4. 4084
    “…BGP promoted cellular senescence after 24 h of treatment, assessed by the increased expression of p53, acetylated-p53 and p21 and senescence associated β-galactosidase activity. …”
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    Hyperphosphatemia Promotes Senescence of Myoblasts by Impairing Autophagy Through Ilk Overexpression, A Possible Mechanism Involved in Sarcopenia
  5. 4085
    “…Some senescent cells acquired the senescence-associated secretory phenotype, and this was accompanied by increased IEC proliferation, implying a role for progrowth inflammatory factors. …”
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    Space radiation triggers persistent stress response, increases senescent signaling, and decreases cell migration in mouse intestine
  6. 4086
    “…Furthermore, PD was able to decrease the level of senescence in TNF‐α‐treated NPCs, as indicated by β‐gal staining as well as senescence markers p53 and p16 expression. …”
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    Polydatin suppresses nucleus pulposus cell senescence, promotes matrix homeostasis and attenuates intervertebral disc degeneration in rats
  7. 4087
    “…As various dietary botanicals have anticancer properties, this study was aimed to examine the effect of Ghost pepper (Bhut Jolokia), one of the hottest chili peppers in the world, on cell proliferation, apoptosis, senescence and the global proteomic profile in human renal cell adenocarcinoma in vitro. 769-P human renal adenocarcinoma cells were cultured on RPMI-1640 media supplemented with fetal bovine serum (10%) and antibiotic-antimycotic solution (1%). …”
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    Effect of ghost pepper on cell proliferation, apoptosis, senescence and global proteomic profile in human renal adenocarcinoma cells
  8. 4088
    “…However, senescence was decreased in HSCs from Mdr2(−/−) mice but returned to normal values in SR(−/−)/Mdr2(−/−) mice. …”
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    Knockout of secretin receptor reduces biliary damage and liver fibrosis in Mdr2(−/−) mice by diminishing senescence of cholangiocytes
  9. 4089
    “…An increased number of senescent cells are associated with age-related tissue degeneration during NAFLD-induced HCC, or during chemotherapeutic treatment. …”
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    Senolytic Cocktail Dasatinib+Quercetin (D+Q) Does Not Enhance the Efficacy of Senescence-Inducing Chemotherapy in Liver Cancer
  10. 4090
    “…During senescence, cells undergo distinctive biochemical and morphological changes and become dysfunctional. …”
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    The mitomiR/Bcl-2 axis affects mitochondrial function and autophagic vacuole formation in senescent endothelial cells
  11. 4091
    por Fu, Jiabin, Yu, Wei, Jiang, Dianming
    Publicado 2018
    “…Background: Nucleus pulposus (NP) cell senescence is an important cellular feature within the degenerative disc. …”
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    Acidic pH promotes nucleus pulposus cell senescence through activating the p38 MAPK pathway
  12. 4092
    “…This treatment induced senescent morphology in HepG-2 cells, which was evaluated by beta-galactosidase staining. …”
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    Antiproliferative Effect of the Isoquinoline Alkaloid Papaverine in Hepatocarcinoma HepG-2 Cells — Inhibition of Telomerase and Induction of Senescence
  13. 4093
    “…The co-expressing genes were used for GO enrichment and signaling pathway enrichment. mRNA expression of the target genes were quantified by qPCR, and cell senescence were investigated by Senescence-Associated Beta-Galactosidase Staining. …”
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    EGF/EGFR upregulates and cooperates with Netrin-4 to protect glioblastoma cells from DNA damage-induced senescence
  14. 4094
    “…ASCs(EMS) are characterized by increased senescence apoptosis, excessive accumulation of reactive oxygen species (ROS), mitochondria deterioration and “autophagic flux.” …”
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    5‐Azacytydine and resveratrol reverse senescence and ageing of adipose stem cells via modulation of mitochondrial dynamics and autophagy
  15. 4095
    “…BACKGROUND: Aging is affected by genetic and environmental factors, and cigarette smoking is strongly associated with accumulation of senescent cells. In this study, we wanted to identify genes that may potentially be beneficial for cell survival in response to cigarette smoke and thereby may contribute to development of cellular senescence. …”
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    RNA sequencing identifies common pathways between cigarette smoke exposure and replicative senescence in human airway epithelia
  16. 4096
    “…SA-β-Gal staining showed the level of cardiomyocyte senescence. FINDINGS: We found that hemin significantly induced the expression of HO-1, which notably suppressed cardiomyocyte senescence containing the secretion of senescence-associated secretory phenotype. …”
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    Heme oxygenase-1 prevents heart against myocardial infarction by attenuating ischemic injury-induced cardiomyocytes senescence
  17. 4097
    “…Based on the pyocyanin-stimulated cyto •OH-induced cellular senescence model, the mechanism by which cyto •OH causes cellular senescence was investigated by adding a supersaturated concentration of H(2) into the cell culture medium. …”
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    Hydrogen Indirectly Suppresses Increases in Hydrogen Peroxide in Cytoplasmic Hydroxyl Radical-Induced Cells and Suppresses Cellular Senescence
  18. 4098
    “…Lung cancer has been one of the most common malignancies in the world. Cell senescence has been recognized as the avenue to inhibit tumor progression. …”
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    Synaptotagmin-7, a binding protein of P53, inhibits the senescence and promotes the tumorigenicity of lung cancer cells
  19. 4099
    “…Leaf senescence is a genetically regulated, highly complex and ordered process. …”
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    Mutation in a putative glycosyltransferase-like gene causes programmed cell death and early leaf senescence in rice
  20. 4100
    “…The activation of cellular senescence throughout the lifespan promotes tumor suppression, whereas the persistence of senescent cells contributes to aspects of aging. …”
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    Cells exhibiting strong p16(INK4a) promoter activation in vivo display features of senescence
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