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  1. 4121
    por Menon, Ramkumar
    Publicado 2019
    “…Similarly, various risk factors of preterm labor and premature rupture of the membranes also cause OS-induced senescence. Data suggest that fetal cell senescence causes inflammatory senescence-associated secretory phenotype (SASP) release. …”
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    Initiation of human parturition: signaling from senescent fetal tissues via extracellular vesicle mediated paracrine mechanism
  2. 4122
    “…Polyamines (PAs) are low molecular weight organic cations comprising biogenic amines that play multiple roles in plant growth and senescence. PA metabolism was found to play a central role in metabolic and genetic reprogramming during dark-induced barley leaf senescence (DILS). …”
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    Polyamines – A New Metabolic Switch: Crosstalk With Networks Involving Senescence, Crop Improvement, and Mammalian Cancer Therapy
  3. 4123
    “…Cellular senescence has been regarded as a mechanism of tumor suppression. …”
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    HNRNPA1-mediated 3′ UTR length changes of HN1 contributes to cancer- and senescence-associated phenotypes
  4. 4124
    “…Aged cMSCs displayed a senescence program characterized by Cdkn2a expression, decreased proliferation and clonogenicity, and acquisition of a senescence‐associated secretory phenotype (SASP). …”
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    Aging induces cardiac mesenchymal stromal cell senescence and promotes endothelial cell fate of the CD90 + subset
  5. 4125
    “…Stress-induced premature cellular senescence is a significant factor in the onset of age-dependent disease in the cardiovascular system. …”
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    The TGF-β1/p53/PAI-1 Signaling Axis in Vascular Senescence: Role of Caveolin-1
  6. 4126
    “…In addition, the expression level of CmNAC60 in the senescing leaves was significantly higher than in the non-senescing leaves. …”
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    Identification of a Novel Melon Transcription Factor CmNAC60 as a Potential Regulator of Leaf Senescence
  7. 4127
    “…Expression of apoptosis and senescence genes (p53, p21, p16, Rbl2, Casp3, Casp9) was determined by qRT-PCR and protein expression analyzed by western blot. …”
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    Cell necrosis, intrinsic apoptosis and senescence contribute to the progression of exencephaly to anencephaly in a mice model of congenital chranioschisis
  8. 4128
    “…Adenosine treatment in combination with the Akt inhibitor, GSK690693, or the silencing of p21 to interfere with the Akt-p21 axis can switch the senescence-to-apoptosis signal and alleviate drug resistance. …”
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    Augmenting the therapeutic efficacy of adenosine against pancreatic cancer by switching the Akt/p21-dependent senescence to apoptosis
  9. 4129
    “…It is critical to regulate the senescence-associated secretory phenotype (SASP) due to its effect on promoting malignant phenotypes and limiting the efficiency of cancer therapy. …”
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    Inactivation of TFEB and NF-κB by marchantin M alleviates the chemotherapy-driven pro-tumorigenic senescent secretion
  10. 4130
    “…PPA treatment reduced senescence signaling as evaluated by senescence‐associated β‐galactosidase activity, PPARγ, p53, and p21 expression in bone. …”
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    3‐(3‐Hydroxyphenyl)‐Propionic Acid (PPA) Suppresses Osteoblastic Cell Senescence to Promote Bone Accretion in Mice
  11. 4131
    “…Senescent microenvironments play an important role in tumor progression. …”
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    Klotho‐mediated targeting of CCL2 suppresses the induction of colorectal cancer progression by stromal cell senescent microenvironments
  12. 4132
    “…Transformation by the ras oncogene can result in promotion of metastasis as well as induction of senescence via increased tissue remodeling, for example, by matrix metalloproteases. …”
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    Regulation of mitochondrial ROS production by HIC‐5: a common feature of oncogene‐induced senescence and tumor invasiveness?
  13. 4133
    por Cho, KyoungJoo, Choi, Seung Ho
    Publicado 2019
    “…The oxLDL-triggered increases in ROS and CD36 elevated active ASK1 in the senescent HAECs. The ROS increase induced apoptosis, whereas CD36 neutralization or ASK1 inhibition protected against cell death. …”
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    ASK1 Mediates Apoptosis and Autophagy during oxLDL-CD36 Signaling in Senescent Endothelial Cells
  14. 4134
    “…Bone marrow stromal cells from patients with myelodysplastic syndrome (MDS) display a senescence phenotype, but the underlying mechanism has not been elucidated. …”
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    Cellular senescence induced by S100A9 in mesenchymal stromal cells through NLRP3 inflammasome activation
  15. 4135
    “…Cellular senescence was examined by senescence-associated β-galactosidase (SA-β-gal) staining. …”
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    Adipose-Derived Mesenchymal Stem Cells Isolated from Patients with Abdominal Aortic Aneurysm Exhibit Senescence Phenomena
  16. 4136
    por Kang, Chanhee
    Publicado 2019
    “…Much effort has been recently made to therapeutically target detrimental effects of cellular senescence including selectively eliminating senescent cells (senolytics) and modulating a proinflammatory senescent secretome (senostatics). …”
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    Senolytics and Senostatics: A Two-Pronged Approach to Target Cellular Senescence for Delaying Aging and Age-Related Diseases
  17. 4137
    “…The accumulation of free radicals and senescence-associated secretory phenotype (SASP) was observed in the sleep-deprived mice. …”
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    Folic Acid Supplementation Suppresses Sleep Deprivation-Induced Telomere Dysfunction and Senescence-Associated Secretory Phenotype (SASP)
  18. 4138
    “…Although aging and senescence have been extensively studied in the past few decades, however, there is lack of clinical treatment available for anti‐aging. …”
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    Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression
  19. 4139
    “…By treating Progerin HEK293 cells with an LPA(3) agonist (OMPT, 1‐Oleoyl‐2‐O‐methyl‐rac‐glycerophosphothionate) and performing shRNA knockdown of the Lpa3r transcript in these cells, we showed that LPA(3) activation increased expression levels of antioxidant enzymes, consequently inhibiting ROS accumulation and ameliorating cell senescence. LPA(3) was shown to be downregulated in HGPS patient fibroblasts through the lysosomal pathway, and it was shown to be crucial for ameliorating ROS accumulation and cell senescence in fibroblasts. …”
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    Lysophosphatidic acid receptor LPA(3) prevents oxidative stress and cellular senescence in Hutchinson–Gilford progeria syndrome
  20. 4140
    “…Despite the observation that circRNAs are known to accumulate in older organisms and have been reported in cellular senescence, their role in aging remains relatively unexplored. …”
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    circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan
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