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4181por Zhang, Zhong-Wei, Yang, Xin-Yue, Zheng, Xiao-Jian, Fu, Yu-Fan, Lan, Ting, Tang, Xiao-Yan, Wang, Chang-Quan, Chen, Guang-Deng, Zeng, Jian, Yuan, Shu“…This study reported, for the first time, that vitamin E is better than vitamin C in delaying seedling senescence caused by macro-element deficiency in Arabidopsis.…”
Publicado 2020
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4182por Cirilli, Ilenia, Orlando, Patrick, Marcheggiani, Fabio, Dludla, Phiwayinkosi V., Silvestri, Sonia, Damiani, Elisabetta, Tiano, Luca“…Moreover, the senescence marker SA-β-galactosidase was observed in both young CSE-exposed and in senescent HUVECs suggesting that CSE exposure accelerates aging in endothelial cells. …”
Publicado 2020
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4183por Bastos, Marta Ferreira, Matias, Manuella de Sousa Toledo, Alonso, Angélica Castilho, Silva, Léia Cristina Rodrigues, de Araújo, Adriana Ladeira, Silva, Paulo Roberto, Benard, Gil, Bocalini, Danilo Sales, Steven Baker, Julien, Leme, Luiz Eugênio GarcezEnlace del recurso
Publicado 2020
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4184por Wu, Hsin-Chieh, Rérolle, Domitille, Berthier, Caroline, Hleihel, Rita, Sakamoto, Takashi, Quentin, Samuel, Benhenda, Shirine, Morganti, Claudia, Wu, Chengchen, Conte, Lidio, Rimsky, Sylvie, Sebert, Marie, Clappier, Emmanuelle, Souquere, Sylvie, Gachet, Stéphanie, Soulier, Jean, Durand, Sylvère, Trowbridge, Jennifer J., Bénit, Paule, Rustin, Pierre, El Hajj, Hiba, Raffoux, Emmanuel, Ades, Lionel, Itzykson, Raphael, Dombret, Hervé, Fenaux, Pierre, Espeli, Olivier, Kroemer, Guido, Brunetti, Lorenzo, Mak, Tak W., Lallemand-Breitenbach, Valérie, Bazarbachi, Ali, Falini, Brunangelo, Ito, Keisuke, Martelli, Maria Paola, de Thé, Hugues“…Our studies reveal an unexpected role for mitochondria downstream of NPM1c and implicate a mitochondrial/ROS/PML/TP53 senescence pathway as an effector of ActD-based therapies. …”
Publicado 2021
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4185por Mandl, Markus, Wagner, Sonja A, Hatzmann, Florian M, Ejaz, Asim, Ritthammer, Heike, Baumgarten, Saphira, Viertler, Hans P, Springer, Jochen, Zwierzina, Marit E, Mattesich, Monika, Brucker, Camille, Waldegger, Petra, Pierer, Gerhard, Zwerschke, Werner“…In the present study, we show that loss-of-function of Sprouty1 by CRISPR/Cas9-mediated genome editing in human ASCs leads to hyper-activation of MAPK signaling and a senescence phenotype. Sprouty1 knockout ASCs undergo an irreversible cell cycle arrest, become enlarged and stain positive for senescence-associated β-galactosidase. …”
Publicado 2020
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4186por Lee, Ok-Hee, Woo, Yun Mi, Moon, Sohyeon, Lee, Jihyun, Park, Haeun, Jang, Hoon, Park, Yun-Yong, Bae, Soo-Kyung, Park, Keun-Hong, Heo, Ji Hoe, Choi, Youngsok“…Here, we show that SIRT6 protects endothelial cells from senescence. SIRT6 expression is progressively decreased during both oxidative stress-induced senescence and replicative senescence. …”
Publicado 2020
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4187por Zhang, Wenjing, Cheng, Wen, Parlato, Rosanna, Guo, Xiaosun, Cui, Xiaopei, Dai, Chaochao, Xu, Lei, Zhu, Jiankang, Zhu, Min, Luo, Kun, Zhang, Wencheng, Dong, Bo, Wang, Jianli, Jiang, Fan“…Senescence of smooth muscle cells (SMCs) has a crucial role in the pathogenesis of abdominal aortic aneurysm (AAA), a disease of vascular degeneration. …”
Publicado 2020
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4188“…In many previous studies, the preventive effects of peanut against aging and cognitive impairment have often been unclear, so to clarify the effects we first investigated effective markers for evaluating its effects in the hippocampus of senescence-accelerated mouse prone/8 (SAMP8) mice, mainly using proteomics. …”
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4189por Gu, Chao, Xu, Huan-Yu, Zhou, Yu-Hang, Yao, Jia-Long, Xie, Zhi-Hua, Chen, Yang-Yang, Zhang, Shao-Ling“…Senescence leads to declines in fruit quality and shortening of shelf life. …”
Publicado 2020
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4190por Makanza, Richard, Zaman-Allah, Mainassara, Cairns, Jill E., Magorokosho, Cosmos, Tarekegne, Amsal, Olsen, Mike, Prasanna, Boddupalli M.“…In addition, in some cases, the correlation between the visual assessment (prone to subjectivity) of crop senescence and the senescence index, calculated from aerial imaging data, was significant. …”
Publicado 2018
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4191“…Replicative cellular senescence is the main cause of aging. It is important to note that early senescence is linked to tissue regeneration, whereas late senescence is known to trigger a chronically inflammatory phenotype. …”
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4192por Bellu, Emanuela, Garroni, Giuseppe, Cruciani, Sara, Balzano, Francesca, Serra, Diletta, Satta, Rosanna, Montesu, Maria Antonia, Fadda, Angela, Mulas, Maurizio, Sarais, Giorgia, Bandiera, Pasquale, Torreggiani, Elena, Martini, Fernanda, Tognon, Mauro, Ventura, Carlo, Beznoska, Jiří, Amler, Evzen, Maioli, Margherita“…Gene expression analysis performed on different senescence associated genes, revealed the activation of a molecular program of rejuvenation in stem cells pretreated with NanoPCL-M and then exposed to UV. …”
Publicado 2020
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4193por Villanueva-Romero, Raúl, Lamana, Amalia, Flores-Santamaría, Marissa, Carrión, Mar, Pérez-García, Selene, Triguero-Martínez, Ana, Tomero, Eva, Criado, Gabriel, Pablos, José L., González-Álvaro, Isidoro, Martínez, Carmen, Juarranz, Yasmina, Gomariz, Rosa P., Gutiérrez-Cañas, Irene“…We characterized the correlation between senescent Th cells and clinic parameters of EA as well as the behavior of senescent Th biomarkers by real-time PCR. …”
Publicado 2020
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4194por Pandey, Kamal, Park, Nahee, Park, Kyung-Soon, Hur, Jin, Cho, Yong Bin, Kang, Minsil, An, Hee-Jung, Kim, Sewha, Hwang, Sohyun, Moon, Yong Wha“…We found that cyclin E-CDK2 mediated phosphorylation of C-MYC is responsible for resistance to CDK4/6 inhibitor by suppressing C-MYC induced senescence. On the contrary, the synergistic anti-proliferative effect of the combined inhibition of CDK2 and CDK4/6 overcomes acquired resistance to CDK4/6 inhibitors by enhancing senescence. …”
Publicado 2020
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4195por Niu, Jing, Gao, Rui-Qi, Cui, Meng-Tian, Zhang, Chen-Guang, Li, Shen-Tao, Cheng, Shan, Ding, Wei“…The expression levels of TCAB1, p21, p16 and p53 were detected by qRT-PCR and western blotting. Staining of senescence-associated β-galactosidase was used to detect senescent cells. …”
Publicado 2021
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4196por Guo, Qiang, Chen, Ximiao, Chen, Jiaoxiang, Zheng, Gang, Xie, Chenglong, Wu, Hongqiang, Miao, Zhimin, Lin, Yan, Wang, Xiangyang, Gao, Weiyang, Zheng, Xiangtao, Pan, Zongyou, Zhou, Yifei, Wu, Yaosen, Zhang, Xiaolei“…The influences of STING on the metabolism of the extracellular matrix (ECM), apoptosis, and senescence, were assessed in STING overexpressing and knocking-down chondrocytes. …”
Publicado 2021
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4197“…Bone marrow stromal cell (BMSC) senescence is highly associated with osteoporosis and limits the application of BMSCs in regenerative medicine. …”
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4198por Wagner, Tina, Pérez-Martínez, Lara, Schellhaas, René, Barrientos-Moreno, Marta, Öztürk, Merve, Prado, Félix, Butter, Falk, Luke, Brian“…Indeed, Sir2, Sin3 and Set2 protein levels are decreased during senescence and their absence may thereby prevent telomere folding. …”
Publicado 2020
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4199por Zhai, Weichao, Tan, Jerome, Russell, Tobias, Chen, Sixun, McGonagle, Dennis, Win Naing, May, Yong, Derrick, Jones, Elena“…Histochemical [Formula: see text] -galactosidase staining is the current standard for measuring hMSC senescence, but this method is destructive and not label-free. …”
Publicado 2021
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4200por Aljobaily, Nouf, Viereckl, Michael J., Hydock, David S., Aljobaily, Hend, Wu, Tsung-Yen, Busekrus, Raquel, Jones, Brandon, Alberson, Jammie, Han, Yuyan“…Conclusion: The data suggest that Cr protected against DOX-induced hepatotoxicity by attenuating fibrosis, inflammation, oxidative stress, and senescence.…”
Publicado 2020
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