“…The age‐associated accumulation of senescent cells is believed to represent one factor contributing to this phenomenon. …”
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“…One likely contributor to iron accumulation is the age-associated increase in tissue-resident senescent cells that drive inflammation and contribute to various pathologies associated with advanced age. …”
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“…Ageing and diabetes lead to similar organ dysfunction that is driven by parallel molecular mechanisms, one of which is cellular senescence. The abundance of senescent cells in various tissues increases with age, obesity and diabetes. …”
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“…Leaf senescence is a degenerative process that is genetically controlled and involves nutrient remobilization prior to the death of leaf tissues. …”
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“…Leaf senescence is a complex mechanism controlled by multiple genetic and environmental variables. …”
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“…Cellular senescence is a state of stable growth arrest in response to stress, which is a fundamental process of biological aging. …”
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“…Our model suggests that, once established, the senescent phenotype should be metastable even if lamina-mediated interactions were reinstated. …”
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“…Loss of OR occurs normally at the menopausal age, a stage called menopausal ovarian senescence. At some periods, there are other sources for ovarian hormones that are away from the ovary, like during use of contraceptive pills and at pregnancy after formation of placenta. …”
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“…While chloroplast contribution to senescence received less attention, recent findings indicate that changes in the redox poise of these organelles strongly affect senescence timing and progress. …”
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“…Cellular senescence is a hallmark of aging, whose onset is linked to a series of both cell and non-cell autonomous processes, leading to several consequences for the organism. …”
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“…Cellular senescence is a stress response that limits the proliferation of damaged cells by establishing a permanent cell cycle arrest. …”
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“…Cellular senescence represents the state of irreversible cell cycle arrest during cell division. …”
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“…Normal cells exposed to cancer-causing events respond by triggering cellular senescence, a stress response which halts cell proliferation and constitutes a protective anti-cancer barrier. …”
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“…Senescence is the irreversible arrest of cell proliferation that has now been shown to play an important role in both health and disease. …”
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“…This review explores the role of senescent MSCs as an important regulator for onset and progression of inflammaging and as an effective target for anti-aging strategies.…”
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“…This review focuses on the characteristics of senescence and on the recent advances in the contribution of p53 to cellular senescence. …”
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“…Bioinformatic and functional data link integrin-mediated cell adhesion to cellular senescence; however, the significance of and molecular mechanisms behind these connections are unknown. …”
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