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  1. 4381
    “…Primary fibroblasts from A‐T patients exhibit premature senescence when grown at ambient oxygen concentration (21%). …”
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    Accelerated replicative senescence of ataxia‐telangiectasia skin fibroblasts is retained at physiologic oxygen levels, with unique and common transcriptional patterns
  2. 4382
    “…Osteoarthritis is a prevalent age-related disease characterized by dysregulation of extracellular matrix metabolism, lipid metabolism, and upregulation of senescence-associated secretory phenotypes. Herein, we clarify that CircRREB1 is highly expressed in secondary generation chondrocytes and its deficiency can alleviate FASN related senescent phenotypes and osteoarthritis progression. …”
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    CircRREB1 mediates lipid metabolism related senescent phenotypes in chondrocytes through FASN post-translational modifications
  3. 4383
    “…Paucity of literature is available regarding the influence of senescent HSCs on behavior of steatotic hepatocytes. …”
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    Secretome of senescent hepatic stellate cells favors malignant transformation from nonalcoholic steatohepatitis-fibrotic progression to hepatocellular carcinoma
  4. 4384
    “…Here, we performed single‐cell RNA sequencing and discovered proliferation heterogeneity as well as spontaneously differentiated and senescent cell subgroups in multiply passaged primary LSC. …”
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    Single‐cell transcriptomics implicates the FEZ1–DKK1 axis in the regulation of corneal epithelial cell proliferation and senescence
  5. 4385
    “…In this study, ROS accumulation induced nucleus pulposus cells (NPCs) senescence is observed in degenerative human and rat intervertebral disc, suggesting senescence as a new therapeutic target to reverse intervertebral disc degeneration (IVDD). …”
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    Rescuing Nucleus Pulposus Cells From Senescence via Dual‐Functional Greigite Nanozyme to Alleviate Intervertebral Disc Degeneration
  6. 4386
    “…These data suggest that ApoE4 exacerbates neuronal senescence due to a deficiency of acetyl‐CoA, which can be ameliorated by GTA supplement. …”
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    ApoE4 exacerbates the senescence of hippocampal neurons and spatial cognitive impairment by downregulating acetyl‐CoA level
  7. 4387
    “…Senescent cells in plaques emerge as a detrimental factor for atherosclerosis (AS), for which targeted senolysis might be a promising therapeutic strategy. …”
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    Targeted elimination of senescent cells by engineered extracellular vesicles attenuates atherosclerosis in ApoE(-/-) mice with minimal side effects
  8. 4388
    “…In the leaf senescence process, transcriptional regulation is a committed step in integrating various senescence-related signals. …”
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    Wheat VQ Motif-Containing Protein VQ25-A Facilitates Leaf Senescence via the Abscisic Acid Pathway
  9. 4389
    “…Here, using premature aging mice (telomerase RNA component knockout, Terc(−/−)), natural aging mice, and in vitro colonoid models, we explore how heat-inactivated Bifidobacterium adolescentis (B. adolescentis) affects colon senescence. We find that B. adolescentis could mitigate colonic senescence-related changes by enhancing intestinal integrity and stimulating the regeneration of Lgr5(+) ISCs via Wnt/β-catenin signaling. …”
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    Heat-inactivated Bifidobacterium adolescentis ameliorates colon senescence through Paneth-like-cell-mediated stem cell activation
  10. 4390
    “…The cellular senescence of mesenchymal stem cells (MSCs) limits their application in regenerative medicine. …”
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    TRAF3IP2 drives mesenchymal stem cell senescence via regulation of NAMPT-mediated NAD biosynthesis
  11. 4391
    “…Furthermore, senescence-based “one-two punch” therapy was validated in clinical trials. …”
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    KDM4C-mediated senescence defense is a targetable vulnerability in gastric cancer harboring TP53 mutations
  12. 4392
    “…Adult tendon stem/progenitor cells (TSPCs) are essential for tendon maintenance, regeneration, and repair, yet they become susceptible to senescence with age, impairing the self-healing capacity of tendons. …”
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    Prim-O-glucosylcimifugin ameliorates aging-impaired endogenous tendon regeneration by rejuvenating senescent tendon stem/progenitor cells
  13. 4393
    “…During in vitro MSC expansion, TG2 is required for cell proliferation and self-renewal by preventing premature senescence but has no effect on the expression of surface antigens and oxidative stress-induced cell death. …”
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    Transglutaminase 2 Prevents Premature Senescence and Promotes Osteoblastic Differentiation of Mesenchymal Stem Cells through NRF2 Activation
  14. 4394
    por Riegger, Jana, Brenner, Rolf E
    Publicado 2023
    “…By meansof a doxorubicine-based in vitro model of stress-induced premature senescence (SIPS), wecould confirm the connection between cellular senescence and amount of CSV. …”
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    Increase of cell surface vimentin is associated with vimentin network disruption and subsequent stress-induced premature senescence in human chondrocytes
  15. 4395
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    Postnatal Maturation of the Blood–Brain Barrier in Senescence-Accelerated OXYS Rats, Which Are Prone to an Alzheimer’s Disease-like Pathology
  16. 4396
    “…Cellular senescence is induced by many stresses including telomere shortening, DNA damage, oxidative, or metabolic stresses. …”
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    Loss of Pla2r1 decreases cellular senescence and age‐related alterations caused by aging and Western diets
  17. 4397
    “…Cellular senescence is a hallmark of aging and has been linked to age-related diseases. …”
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    Iron derived from NCOA4-mediated ferritinophagy causes cellular senescence via the cGAS-STING pathway
  18. 4398
    “…Physiologically aged lungs are prone to senescence-associated pulmonary diseases (SAPD). This study aimed to determine the mechanism and subtype of aged T cells affecting alveolar type II epithelial (AT2) cells, which promote the pathogenesis of senescence-associated pulmonary fibrosis (SAPF). …”
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    IFNγ Transcribed by IRF1 in CD4(+) Effector Memory T Cells Promotes Senescence-Associated Pulmonary Fibrosis
  19. 4399
    “…Saccharomyces cerevisiae telomerase-negative cells undergo homologous recombination on subtelomeric or TG(1–3) telomeric sequences, thus allowing Type I or Type II post-senescence survival, respectively. Here, we find that the DNA damage sensors, Mec1, Mec3 and Rad24 control Type II recombination, while the Rad9 adaptor protein and the Rad53 and Chk1 effector kinases have no effect on survivor type selection. …”
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    Control of the yeast telomeric senescence survival pathways of recombination by the Mec1 and Mec3 DNA damage sensors and RPA
  20. 4400
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    Correction: Vaccine Efficacy in Senescent Mice Challenged with Recombinant SARS-CoV Bearing Epidemic and Zoonotic Spike Variants
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