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4581por Liu, Feilin, Shi, Jiahong, Zhang, Yingyao, Lian, Aobo, Han, Xing, Zuo, Kuiyang, Liu, Mingsheng, Zheng, Tong, Zou, Fei, Liu, Xiaomei, Jin, Minghua, Mu, Ying, Li, Gang, Su, Guanfang, Liu, Jinyu“…In conclusion, our findings show that NANOG delays HF-MSC senescence by upregulating PBX1 and activating AKT signaling and that a feedback loop likely exists between PBX1 and AKT signaling.…”
Publicado 2019
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4582por Xiang, Yue, Wang, Shun-he, Wang, Lu, Wang, Zi-ling, Yao, Hui, Chen, Lin-bo, Wang, Ya-ping“…This is a study on the relationship between the protective effect of ginsenoside Rg1 on senescent neural stem cells and Wnt-β/catenin signaling pathway. …”
Publicado 2019
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4583por Lin, Hanqing, Xiong, Hao, Su, Zhongwu, Pang, Jiaqi, Lai, Lan, Zhang, Huasong, Jian, Bingquan, Zhang, Weijian, Zheng, Yiqing“…Methods: We induced cellular and cochlear senescence using hydrogen peroxide (H(2)O(2)) and evaluated the level of senescence through senescence-associated β-galactosidase staining. …”
Publicado 2019
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4584por Bian, Xiaohui, Griffin, Tomás P, Zhu, Xiangyang, Islam, Md Nahidul, Conley, Sabena M, Eirin, Alfonso, Tang, Hui, O’Shea, Paula M, Palmer, Allyson K, McCoy, Rozalina G, Herrmann, Sandra M, Mehta, Ramila A, Woollard, John R, Rule, Andrew D, Kirkland, James L, Tchkonia, Tamar, Textor, Stephen C, Griffin, Matthew D, Lerman, Lilach O, Hickson, LaTonya J“…OBJECTIVE: Activin A, an inflammatory mediator implicated in cellular senescence-induced adipose tissue dysfunction and profibrotic kidney injury, may become a new target for the treatment of diabetic kidney disease (DKD) and chronic kidney diseases. …”
Publicado 2019
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4585por Seok, Jin, Jung, Hyun Sook, Park, Sohae, Lee, Jung Ok, Kim, Chong Jai, Kim, Gi Jin“…However, a limited lifespan by senescence through mechanisms that are well unknown is the greatest obstacle. …”
Publicado 2020
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4586por Guan, Ruijuan, Cai, Zhou, Wang, Jian, Ding, Mingjing, Li, Ziying, Xu, Jingyi, Li, Yuanyuan, Li, Jingpei, Yao, Hongwei, Liu, Wei, Qian, Jing, Deng, Bingxian, Tang, Chun, Sun, Dejun, Lu, Wenju“…Sirtuin 1 (SIRT1) has been shown to protect against mitochondrial dysfunction and other pathological processes, including premature senescence. This study was aimed to investigate whether and how H(2)S attenuates senescence and apoptosis of alveolar epithelial cells via a SIRT1-dependent mechanism. …”
Publicado 2019
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4587H(2)O(2) as a Feedback Signal on Dual-Located WHIRLY1 Associates with Leaf Senescence in Arabidopsispor Lin, Wenfang, Huang, Dongmei, Shi, Ximiao, Deng, Ban, Ren, Yujun, Lin, Wenxiong, Miao, Ying“…Leaf senescence, either as a natural stage of development or as an induced process under stress conditions, incorporates multiple intricate signaling pathways. …”
Publicado 2019
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4588por Bigan, Erwan, Sasidharan Nair, Satish, Lejeune, François-Xavier, Fragnaud, Hélissande, Parmentier, Frédéric, Mégret, Lucile, Verny, Marc, Aaronson, Jeff, Rosinski, Jim, Neri, Christian“…Scn4b) and cellular senescence (e.g. Cdkn2a products) responses. Top striatal weighted edges are enriched in modulators of defective behavior in invertebrate models of HD pathogenesis, validating their relevance to neuronal dysfunction in vivo. …”
Publicado 2020
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4589“…Spalax fibroblasts undergo replicative senescence (RS) and etoposide‐induced senescence (EIS), evidenced by an increased activity of senescence‐associated beta‐galactosidase (SA‐β‐Gal), growth arrest, and overexpression of p21, p16, and p53 mRNAs. …”
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4590por Sasaki, Yuichi, Ikeda, Yoshiyuki, Miyauchi, Takahiro, Uchikado, Yoshihiro, Akasaki, Yuichi, Ohishi, Mitsuru“…Aim: Menopause causes arterial senescence and atherosclerotic development through decrease of estrogen. …”
Publicado 2020
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4591“…In addition, it was revealed that the iPSC-CNEV restored senescence-related alterations of gene expression. Treatment with iPSC-CENVs significantly reduced the activity of senescence-associated-β-galactosidase (SA-β-Gal) in senescent HDFs, as well as suppressing the elevated expression of p53 and p21, key factors involved in cell cycle arrest, apoptosis, and cellular senescence signaling pathways. …”
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4592por Jang, Ik-Soon, Jo, Eunbi, Park, Soo Jung, Baek, Su Jeong, Hwang, In-Hu, Kang, Hyun Mi, Lee, Je-Ho, Kwon, Joseph, Son, Junik, Kwon, Ho Jeong, Choi, Jong-Soon“…Restoration of senescence by ginsenosides has not been explored so far. …”
Publicado 2020
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4593por Mensà, Emanuela, Guescini, Michele, Giuliani, Angelica, Bacalini, Maria Giulia, Ramini, Deborah, Corleone, Giacomo, Ferracin, Manuela, Fulgenzi, Gianluca, Graciotti, Laura, Prattichizzo, Francesco, Sorci, Leonardo, Battistelli, Michela, Monsurrò, Vladia, Bonfigli, Anna Rita, Cardelli, Maurizio, Recchioni, Rina, Marcheselli, Fiorella, Latini, Silvia, Maggio, Serena, Fanelli, Mirco, Amatori, Stefano, Storci, Gianluca, Ceriello, Antonio, Stocchi, Vilberto, De Luca, Maria, Magnani, Luca, Rippo, Maria Rita, Procopio, Antonio Domenico, Sala, Claudia, Budimir, Iva, Bassi, Cristian, Negrini, Massimo, Garagnani, Paolo, Franceschi, Claudio, Sabbatinelli, Jacopo, Bonafè, Massimiliano, Olivieri, Fabiola“…The role of epigenetics in endothelial cell senescence is a cutting-edge topic in ageing research. …”
Publicado 2020
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4594“…Increased injuries were observed by upregulating endothelial apoptosis- and senescence-positive staining, along with caspase-3 activity and down-regulating telomerase activity. …”
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4595por Zhang, Chi, Xie, Yun, Chen, Haicheng, Lv, Linyan, Yao, Jiahui, Zhang, Min, Xia, Kai, Feng, Xin, Li, Yanqing, Liang, Xiaoyan, Sun, Xiangzhou, Deng, Chunhua, Liu, Guihua“…Male late-onset hypogonadism is an age-related disease, the core mechanism of which is dysfunction of senescent Leydig cells. Recent studies have shown that elimination of senescent cells can restore proper homeostasis to aging tissue. …”
Publicado 2020
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4596“…To address this issue, we investigated the effect of melatonin on replicative senescence in MSCs. In senescent MSCs (late passage), replicative senescence decreased mitophagy by inhibiting mitofission, resulting in the augmentation of mitochondrial dysfunction. …”
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4597por Mytych, Jennifer, Sołek, Przemysław, Będzińska, Agnieszka, Rusinek, Kinga, Warzybok, Aleksandra, Tabęcka-Łonczyńska, Anna, Koziorowski, Marek“…Immunosenescence in monocytes has been shown to be associated with several biochemical and functional changes, including development of senescence-associated secretory phenotype (SASP), which may be inhibited by klotho protein. …”
Publicado 2020
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4598por Xie, Lihua, Cai, Miaomiao, Li, Xiangyu, Zheng, Huifang, Xie, Yali, Cheng, Zhanchao, Bai, Yucong, Li, Juan, Mu, Shaohua, Gao, Jian“…These findings show that PheNAC3 may participate in leaf senescence and play critical roles in the salt and drought stress response.…”
Publicado 2020
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4599“…To better understand the molecular control of leaf senescence, we examined transcriptome changes during seasonal leaf senescence in Populus trichocarpa Nisqually-1, the Populus reference genome, growing in its natural habitat. …”
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4600“…The defects observed in the muscle and SAT may occur independent of cellular senescence or alterations in mitochondrial function. …”
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