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  1. 4601
    “…The formation of micronuclei (MN) is prevalent in human cancer cells and its role in activating the senescence-associated secretory phenotype (SASP) machinery has been identified recently. …”
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    N-Acetyltransferase 10 Promotes Micronuclei Formation to Activate the Senescence-Associated Secretory Phenotype Machinery in Colorectal Cancer Cells
  2. 4602
    “…DNA damage, caused by various oncogenic stresses, can induce cell death or cellular senescence as an important tumor suppressor mechanism. …”
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    DNA Damage Regulates Senescence-Associated Extracellular Vesicle Release via the Ceramide Pathway to Prevent Excessive Inflammatory Responses
  3. 4603
    “…Hepatocyte-specific Fbp1 deletion results in steatosis, concomitant with activation and senescence of hepatic stellate cells (HSCs), exhibiting a senescence-associated secretory phenotype (SASP). …”
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    FBP1 loss disrupts liver metabolism and promotes tumourigenesis through a hepatic stellate cell senescence secretome
  4. 4604
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    Erratum: The p66shc-Mediated Regulation of Hepatocyte Senescence Influences Hepatic Steatosis in Nonalcoholic Fatty Liver Disease
  5. 4605
    “…The assumption that lifelong increased brood size reduced somatic state was supported: Birds rearing enlarged broods showed subsequent increased rate of actuarial senescence, resulting in reduced residual life span. 6. …”
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    Experimentally increased brood size accelerates actuarial senescence and increases subsequent reproductive effort in a wild bird population
  6. 4606
    “…However, biological principles – such as cellular senescence – remain difficult to implement in molecularly informed treatment decisions. …”
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    H3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients
  7. 4607
    “…Our study showed that obesity affects mainly the biological functions of MSCs obtained from bone marrow and vWAT by decreasing the proliferation rate, reducing the percentage of cells in S phase and triggering senescence. The onset of senescence was confirmed by expression of genes belonging to RB and P53 pathways. …”
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    Obesity is associated with senescence of mesenchymal stromal cells derived from bone marrow, subcutaneous and visceral fat of young mice
  8. 4608
    “…Heat acclimation or activation of leaf senescence, are two main strategies when tall fescue is exposed to heat stress (HS). …”
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    SMRT and Illumina RNA sequencing reveal novel insights into the heat stress response and crosstalk with leaf senescence in tall fescue
  9. 4609
    “…Currently, the intracellular response of the senescence marker p16(Ink4a) to the long noncoding RNA is being actively studied. …”
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    Lamivudine Inhibits Alu RNA-induced Retinal Pigment Epithelium Degeneration via Anti-inflammatory and Anti-senescence Activities
  10. 4610
    por Huang, Yujia, Liu, Tao
    Publicado 2020
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    Step further towards targeted senolytic therapy: therapeutic potential of uPAR-CAR T cells for senescence-related diseases
  11. 4611
    “…Replicative senescence is a hallmark of aging, which also contributes to individual aging. …”
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    Single-Cell Transcriptome Analysis Reveals Six Subpopulations Reflecting Distinct Cellular Fates in Senescent Mouse Embryonic Fibroblasts
  12. 4612
    por Shen, Junyan, Zhu, Xiaoqi, Liu, Hailiang
    Publicado 2020
    “…Recently identified microRNAs (miRNAs) have emerged as critical modulators of cellular senescence. In this study, we examined the changes in hADSCs undergoing senescence. …”
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    MiR-483 induces senescence of human adipose-derived mesenchymal stem cells through IGF1 inhibition
  13. 4613
    “…Results: IL-1β-induced cellular senescence of rat astrocytes was accompanied by increased total and phosphorylated tau. …”
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    Interleukin-1β Drives Cellular Senescence of Rat Astrocytes Induced by Oligomerized Amyloid β Peptide and Oxidative Stress
  14. 4614
    “…CONCLUSION: Unique immunologic abnormalities, CD8 T‐cell senescence, and shortened telomere together as a hallmark occur in young DC patients before progression to severe disease.…”
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    CD8(+) T‐cell senescence and skewed lymphocyte subsets in young Dyskeratosis Congenita patients with PARN and DKC1 mutations
  15. 4615
    “…Our results showed that curcumin induced ROS accumulation, apoptosis, autophagy, cell cycle arrest, and cellular senescence accompanied by upregulation of p53 and p21 proteins in SiHa cells.…”
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    Curcumin induces G2/M arrest and triggers autophagy, ROS generation and cell senescence in cervical cancer cells
  16. 4616
    “…Consequently, in the present study, this mechanism was thoroughly evaluated employing a dementia mice model, specifically the senescence-accelerated mouse prone 8. The mice were exposed to a mixture of lemon and rosemary oil at nighttime as well as to a mixture of lavender and orange oil in the daytime for 2 months. …”
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    Aromatherapy improves cognitive dysfunction in senescence-accelerated mouse prone 8 by reducing the level of amyloid beta and tau phosphorylation
  17. 4617
    “…The ATM and ATR inhibitors were effectively inducing senescence when combined with IR. The DNA-PK inhibitor was not an important inductor of senescence. …”
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    Senescence Induction by Combined Ionizing Radiation and DNA Damage Response Inhibitors in Head and Neck Squamous Cell Carcinoma Cells
  18. 4618
    “…Inhibition of BMI1 decreases cell self-renewal and attenuates tumor growth due to induction of senescence. Prolonged BMI1 inhibition induces a senescence-associated secretory phenotype, which promotes tumor recurrence. …”
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    Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG
  19. 4619
    “…Moreover, METTL3/14 levels progressively decline in cells undergoing replicative senescence. Overexpression of METTL14 attenuates both replicative senescence and premature senescence. …”
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    Lamin A safeguards the m(6)A methylase METTL14 nuclear speckle reservoir to prevent cellular senescence
  20. 4620
    “…The present study examined whether the OPN deficiency was susceptible to OA through the regulation of chondrocyte senescence and apoptosis and the expressions of OA-associated genes. …”
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    OPN Deficiency Increases the Severity of Osteoarthritis Associated with Aberrant Chondrocyte Senescence and Apoptosis and Upregulates the Expression of Osteoarthritis-Associated Genes
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