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4741“…PURPOSE: Cellular senescence participates in the occurrence and development of chronic obstructive pulmonary disease (COPD). …”
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4742por Thadathil, Nidheesh, Selvarani, Ramasamy, Mohammed, Sabira, Nicklas, Evan H., Tran, Albert L., Kamal, Maria, Luo, Wenyi, Brown, Jacob L., Lawrence, Marcus M., Borowik, Agnieszka K., Miller, Benjamin F., Van Remmen, Holly, Richardson, Arlan, Deepa, Sathyaseelan S.“…The goal of this study was to test the role cellular senescence plays in the increased inflammation, chronic liver disease, and hepatocellular carcinoma seen in mice null for Cu/Zn‐Superoxide dismutase (Sod1KO). …”
Publicado 2022
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4743por Siqueira, Ionara Rodrigues, de Souza Rodrigues, Andressa, Flores, Marina Siqueira, Vieira Cunha, Eduarda Letícia, Goldberg, Madeleine, Harmon, Brennan, Batabyal, Rachael, Freishtat, Robert J., Cechinel, Laura Reck“…Considering that in vitro findings have shown the involvement of microRNA in extracellular vesicles and particles (EVPs) on senescence, we hypothesized that circulating EVPs derived from adipocytes can be involved in the aging process via their microRNA cargo. …”
Publicado 2022
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4744“…Here, we demonstrated that amyloid-β (Aβ) accelerated cell senescence characterized by the upregulation of p21 and PAI-1 as well as senescence-associated beta-galactosidase (SA-β-gal) in human microglial cells. …”
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4746por Chuang, Hsiang-Hao, Huang, Ming-Shyan, Zhen, Yen-Yi, Chuang, Cheng-Hao, Lee, Ying-Ray, Hsiao, Michael, Yang, Chih-Jen“…We also found that ectopic EZH2 expression attenuates FAK-inhibition-induced cellular senescence in lung cancer cells. Our results identify EZH2 as a critical downstream effector of the FAK-mediated anti-senescence pathway. …”
Publicado 2022
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4747“…BACKGROUND: Cellular senescence is a key element in the occurrence and progression of a variety of tumors. …”
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4748por Arvia, Rosaria, Zakrzewska, Krystyna, Giovannelli, Lisa, Ristori, Sara, Frediani, Elena, Del Rosso, Mario, Mocali, Alessandra, Stincarelli, Maria A, Laurenzana, Anna, Fibbi, Gabriella, Margheri, Francesca“…OBJECTIVE: Emerging evidence demonstrates that excessive accumulation of senescent cells is associated with some chronic diseases and suggests a pathogenic role of cellular senescence in fibrotic processes, such as that occurring in ageing or in SSc. …”
Publicado 2021
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4749por Zhou, Yanling, Xiao, Liang, Long, Guo, Cao, Jing, Liu, Shuang, Tao, Yongguang, Zhou, Ledu, Tang, Jianing“…Breast cancer is a malignancy with the highest incidence and mortality in women worldwide. Senescence is a model of arrest in the cell cycle, which plays an important role in tumor progression, while the prognostic value of cellular senescence-related genes (SRGs) in evaluating immune infiltration and clinical outcomes of breast cancer needs further investigation. …”
Publicado 2022
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4750por Rangarajan, Sunad, Locy, Morgan L., Chanda, Diptiman, Kurundkar, Ashish, Kurundkar, Deepali, Larson‐Casey, Jennifer L., Londono, Pilar, Bagchi, Rushita A., Deskin, Brian, Elajaili, Hanan, Nozik, Eva S., Deshane, Jessy S., Zmijewski, Jaroslaw W., Eickelberg, Oliver, Thannickal, Victor J.“…We provide evidence that implicates chronic elevation of the mitochondrial anion carrier protein, uncoupling protein‐2 (UCP2), in increased generation of reactive oxygen species, altered redox state and cellular bioenergetics, impaired fatty acid oxidation, and induction of myofibroblast senescence. This pro‐oxidant senescence reprogramming occurs in concert with conventional actions of UCP2 as an uncoupler of oxidative phosphorylation with dissipation of the mitochondrial membrane potential. …”
Publicado 2022
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4751por Sun, Rui, Wang, Xu, Chen, Jiajie, Teng, Da, Chan, Shixin, Tu, Xucan, Wang, Zhenglin, Zuo, Xiaomin, Wei, Xiang, Lin, Li, Zhang, Qing, Zhang, Xiaomin, Tang, Kechao, Zhang, Huabing, Chen, Wei“…Background: Cellular senescence is a typical irreversible form of life stagnation, and recent studies have suggested that long non-coding ribonucleic acids (lncRNA) regulate the occurrence and development of various tumors. …”
Publicado 2022
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4752“…Cellular senescence is a form of irreversible growth arrest that cancer cells evade. …”
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4753por Gao, Ying, Kamogashira, Teru, Fujimoto, Chisato, Iwasaki, Shinichi, Yamasoba, TatsuyaEnlace del recurso
Publicado 2022
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4754por Wang, Lan, Wan, Ruyan, Chen, Xinyu, Guo, Xiaoshu, Li, Zhongzheng, Zhao, Weiming, Yan, Peishuo, Yu, Guoying“…We examined the roles of MAD2L1 in ROS production, mitochondrial function, cell senescence, and the establishment of a profibrotic microenvironment. …”
Publicado 2022
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4755“…The cell senescence-related risk model was generated by using six cell senescence-related lncRNAs, and the risk score was calculated. …”
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4756por Sasi, Jyothish Madambikattil, VijayaKumar, Cheeni, Kukreja, Bharti, Budhwar, Roli, Shukla, Rohit Nandan, Agarwal, Manu, Katiyar-Agarwal, Surekha“…Though histochemical studies have helped in understanding the pattern of cell death in senescing rice coleoptiles, genome-wide expression changes during coleoptile senescence have not yet been explored. …”
Publicado 2022
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4757por Eleftheriadis, Theodoros, Pissas, Georgios, Golfinopoulos, Spyridon, Efthymiadi, Maria, Liakopoulos, Vassilios, Stefanidis, Ioannis“…Thus, inhibition of the Krebs cycle at the level of MDH-2 protects RPTECs from anoxia-reoxygenation-induced death or senescence. MDH-2 may be a promising pharmaceutical target against ischemia-reperfusion injury.…”
Publicado 2022
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4758“…Furthermore, prolonged IGF1 treatment leads to the establishment of a premature senescence phenotype characterized by a unique senescence network signature. …”
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4759“…Furthermore, Nr1d1 was negatively associated with cell proliferation, promoting apoptosis and senescence-associated beta-galactosidase production in MCMs. …”
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4760“…The results revealed that (1) the root biomass of L. japonica increased significantly during senescence, even after the leaves withered. (2) The root diameter of L. japonica decreased significantly, while root weight per volume and root superficial area per volume increased significantly during senescence. …”
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