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  1. 4761
    “…TMAO promoted AAA development in mouse AAA models induced by AngII and CaCl(2) by a mechanism involving cellular senescence. GRAPHICAL ABSTRACT: [Image: see text]…”
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    Trimethylamine N-Oxide Promotes Abdominal Aortic Aneurysm Formation by Aggravating Aortic Smooth Muscle Cell Senescence in Mice
  2. 4762
    “…Moreover, it might mediate the EVs via senescence-related pathways in COPD patients with HUA. …”
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    Extracellular vesicles isolated from hyperuricemia patients might aggravate airway inflammation of COPD via senescence-associated pathway
  3. 4763
    por Takaya, Kento, Asou, Toru, Kishi, Kazuo
    Publicado 2022
    “…There is growing evidence that the appearance and texture of the skin that is altered during the aging process are considerably enhanced by the accumulation of senescent dermal fibroblasts. These senescent cells magnify aging via an inflammatory, histolytic, and senescence-associated secretory phenotype (SASP). …”
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    Downregulation of senescence-associated secretory phenotype by knockdown of secreted frizzled-related protein 4 contributes to the prevention of skin aging
  4. 4764
    “…To clarify the effects of FO and FP on brain function, we investigated whether FO or FP feeding can prevent age-related cognitive dysfunction in senescence-accelerated mouse-prone 10 (SAMP10) mice. …”
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    Protective Effects of Fish (Alaska Pollock) Protein Intake against Short-Term Memory Decline in Senescence-Accelerated Mice
  5. 4765
    “…Cellular senescence is linked with chemotherapy resistance. Based on previous studies, GRP78 is a signal transducer in senescent cells. …”
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    Cisplatin Induces Senescent Lung Cancer Cell-Mediated Stemness Induction via GRP78/Akt-Dependent Mechanism
  6. 4766
    “…However, the interactions among different modes of exercise on endothelial senescence, the development of arterial vascular stiffness, and the associated molecular mechanisms are not completely understood. …”
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    Changes in Arterial Stiffness in Response to Various Types of Exercise Modalities: A Narrative Review on Physiological and Endothelial Senescence Perspectives
  7. 4767
    “…Rational: Senescence is a major aging process that contributes to the development of cardiovascular diseases, but the underlying molecular mechanisms remain largely unknown. …”
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    circHIPK3 prevents cardiac senescence by acting as a scaffold to recruit ubiquitin ligase to degrade HuR
  8. 4768
    “…Furthermore, we discovered that valproic acid attenuated diabetes-induced upregulation of complement C5a receptors, with a concomitant reduction in markers of cellular senescence and senescence-associated secretory phenotype. …”
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    Valproic acid attenuates cellular senescence in diabetic kidney disease through the inhibition of complement C5a receptors
  9. 4769
    por Ju, Sang Hyeon, Ku, Bon Jeong
    Publicado 2022
    “…We will explore the effects of statin/ezetimibe therapy on CD8 + T cell senescence in patients with T2DM and hypercholesterolemia. …”
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    Effects of rosuvastatin/ezetimibe on senescence of CD8+ T-cell in type 2 diabetic patients with hypercholesterolemia: A study protocol
  10. 4770
    “…Further results of the cellular mechanism showed that the apoptotic markers of Terminal deoxynucleotidyl Transferase-mediated dUTP Nick End Labeling (TUNEL) and Caspase3 and the cell senescent markers of senescence-associated β-galactosidase (SA-β-Gal) and nuclear LAMNB1 have changed significantly in the IPC-1min group, compared with the control group. …”
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    Remote ischemic postconditioning protects against crush-induced acute kidney injury via down-regulation of apoptosis and senescence
  11. 4771
    por Takaya, Kento, Asou, Toru, Kishi, Kazuo
    Publicado 2022
    “…Skin senescence is characterized by a decrease in extracellular matrix and the accumulation of senescent fibroblasts in the dermis, and their secretion of humoral factors. …”
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    Aging Fibroblasts Adversely Affect Extracellular Matrix Formation via the Senescent Humoral Factor Ependymin-Related Protein 1
  12. 4772
    “…They have more replicative senescence when exposed to environmental and oxidative insults, resulting in human skin aging. …”
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    Preventive Effect of Nuciferine on H(2)O(2)-Induced Fibroblast Senescence and Pro-Inflammatory Cytokine Gene Expression
  13. 4773
    “…CD4(+) T, CD8(+) T, and senescent T cell subsets were determined by flow cytometry based on staining for specific intracellular cytokines. …”
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    Increased Pro-Inflammatory T Cells, Senescent T Cells, and Immune-Check Point Molecules in the Placentas of Patients With Gestational Diabetes Mellitus
  14. 4774
    “…Cellular senescence is a plausible mediator of age-associated declines in physical performance. …”
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    Associations between biomarkers of cellular senescence and physical function in humans: observations from the lifestyle interventions for elders (LIFE) study
  15. 4775
    “…AIMS: Insulin like growth factor binding protein 7 (IGFBP7) is a marker of senescence secretome and a novel biomarker in patients with heart failure (HF). …”
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    Insulin‐like growth factor binding protein 7 (IGFBP7), a link between heart failure and senescence
  16. 4776
    “…These data indicate that high-concentration trehalose can induce the senescence-like state in fibroblasts via CDKN1A/p21, which may be therapeutically useful for optimal wound repair.…”
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    Highly concentrated trehalose induces prohealing senescence-like state in fibroblasts via CDKN1A/p21
  17. 4777
    “…Cellular senescence and the senescence-associated secretory phenotype (SASP) are implicated in aging and age-related disease, and SASP-related inflammation is thought to contribute to tissue dysfunction in aging and diseased animals. …”
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    Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling
  18. 4778
    “…Growth differentiation factor 15 (GDF15) is a stress‐responsive cytokine also known as a mitokine; however, its role in mitochondrial homeostasis and cellular senescence remained elusive. We show here that knocking down GDF15 expression in human dermal fibroblasts induced mitochondrial dysfunction and premature senescence, associated with a distinct senescence‐associated secretory phenotype. …”
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    Depletion of growth differentiation factor 15 (GDF15) leads to mitochondrial dysfunction and premature senescence in human dermal fibroblasts
  19. 4779
    “…Notably, inhibition of AhR could improve cellular senescence of injured kidneys, which was indicated by senescence-associated β-galactosidase (SA-β-gal) activity, biomarker p53, p21, p16 expression, and secretory-associated secretory phenotype IL-1β, IL-6 and TNFα level. …”
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    Tubular aryl hydratocarbon receptor upregulates EZH2 to promote cellular senescence in cisplatin-induced acute kidney injury
  20. 4780
    “…This study demonstrated that MRK-107-induced senescence with the involvement of oxidative stress is a possible mechanism of action, addressing this compound as a potential antitumor drug against chronic myeloid leukemia.…”
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    Selenylated Imidazo[1,2-a]pyridine Induces Cell Senescence and Oxidative Stress in Chronic Myeloid Leukemia Cells
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