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5081por Cortesi, Emanuela E., Meeusen, Bob, Vanstapel, Arno, Verleden, Stijn E., Vanaudenaerde, Bart M., Wuyts, Wim A., Janssens, Wim, Janssens, Veerle, Roskams, Tania, Ventura, Juan-José“…Several studies have highlighted an increased expression of senescence-related markers in the resident progenitor cells in COPD and IPF, possibly undermining epithelial integrity and contributing to the progression and the aggravation of both diseases. …”
Publicado 2021
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5082por Hu, Liang, Du, Conglin, Yang, Zi, Yang, Yang, Zhu, Zhao, Shan, Zhaochen, Zhang, Chunmei, Wang, Songlin, Liu, Fei“…Hedgehog activation likely preserves parotid macrophages after radiation through inhibition of P53 signaling and consequent cellular senescence. Consistently, VEGF, an essential anti-senescence cytokine downstream of Hedgehog signaling, is significantly decreased by radiation but recovered by transient Hedgehog activation. …”
Publicado 2021
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5083por Kong, Peng, Li, Chang-Lin, Dou, Yong-Qing, Cao, Li, Zhang, Xiao-Yun, Zhang, Wen-Di, Bi, Ze-Qi, Peng, Zu-Yi, Yan, An-Qi, Han, Mei“…Vascular smooth muscle cell (VSMC) senescence is a major driver of neointimal formation. …”
Publicado 2021
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5084por Zhao, Renliang, Jin, Xiangyun, Li, Ang, Xu, Bitong, Shen, Yifan, Wang, Wei, Huang, Jinghuan, Zhang, Yadong, Li, Xiaolin“…Diabetic ulcers, a difficult problem faced by clinicians, are strongly associated with an increase in cellular senescence. Few empirical studies have focused on exploring a targeted strategy to cure diabetic wounds by eliminating senescent fibroblasts (SFs) and reducing side effects. …”
Publicado 2021
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5085“…Cell proliferation (PCNA), cell death (active caspase-3), senescence (p16), osteoclast (RANK), osteoblast (OPG), osteoblast progenitor (c-Kit), and osteoclastogenesis-associated secretory factors (like RANKL) were assessed using immunostaining. …”
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5086por Shao, Changjian, Guo, Kai, Xu, Liqun, Zhang, Yimeng, Duan, Hongtao, Feng, Yingtong, Pan, Minghong, Lu, Di, Ren, Xiaoya, Ganti, Apar Kishor, Hakozaki, Taiki, Han, Jing, Yan, Xiaolong, Ma, Zhiqiang“…BACKGROUND: Senescence marker protein 30 (SMP30), which plays a pivotal role as a suppressor protein in cell proliferation, among other regulatory actions, is a marker of aging that shows decreased expression during senescence. …”
Publicado 2021
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5087por Liu, Boyuan, Zhou, Zewei, Jin, Yu, Lu, Jinying, Feng, Dongju, Peng, Rui, Sun, Hua, Mu, Xiaoxin, Li, Changxian, Chen, Yun“…S. maltophilia provoked senescence-associated secretory phenotype (SASP) in HSCs by activating TLR-4-mediated NF-κB signaling pathway, which in turn induced NLRP3 inflammasome complex formation and secreted various inflammatory factors in the liver, thus facilitating HCC progression in mice. …”
Publicado 2022
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5088por Liisborg, Charlotte, Skov, Vibe, Kjær, Lasse, Hasselbalch, Hans Carl, Sørensen, Torben Lykke“…SASP is thought to play a role in driving CLI seen with advancing age. Senescent cells with SASP may damage healthy tissue, including the eye tissues affected in AMD. …”
Publicado 2021
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5089por Blackmore, Daniel G., Turpin, Fabrice, Palliyaguru, Tishila, Evans, Harrison T., Chicoteau, Antony, Lee, Wendy, Pelekanos, Matthew, Nguyen, Nghia, Song, Jae, Sullivan, Robert K. P., Sah, Pankaj, Bartlett, Perry F., Götz, Jürgen“…Here, we demonstrate in the physiologically aged, senescent mouse brain that scanning ultrasound combined with microbubbles (SUS(+MB)), by transiently opening the blood–brain barrier, fully restores LTP induction in the dentate gyrus of the hippocampus. …”
Publicado 2021
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5090“…Leaf senescence is a critical process in plants and has a direct impact on many important agronomic traits. …”
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5091por Jalan‐Sakrikar, Nidhi, De Assuncao, Thiago M., Navarro‐Corcuera, Amaia, Hamdan, Feda H., Loarca, Lorena, Kirkeby, Lindsey A., Resch, Zachary T., O’Hara, Steven P., Juran, Brian D., Lazaridis, Konstantinos N., Rosen, Charles B., Heimbach, Julie K., Taner, Timucin, Shah, Vijay H., LaRusso, Nicholas F., Huebert, Robert C.“…RNA sequencing (RNA‐seq) on iDCs showed significant differences in gene expression patterns, including enrichment of pathways associated with cell cycle, senescence, and hepatic fibrosis, that correlate with PSC. …”
Publicado 2021
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5092por Gu, Xunhu, Zhang, Ge, Qin, Zhengfang, Yin, Min, Chen, Weiping, Zhang, Yangbo, Liu, Xu“…Alzheimer’s disease (AD) is a neurodegenerative disorder that is pathologically related to oxidative stress and cellular senescence. Safinamide is one of the clinically prescribed monoamine oxidase B (MAOB) inhibitors. …”
Publicado 2022
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5093por Bayer, Abraham L., Pietruska, Jodie, Farrell, Jaymes, McRee, Siobhan, Alcaide, Pilar, Hinds, Philip W.“…The AKT family of genes are a major regulator of cellular proliferation and senescence; therefore, we sought to study each of the three AKT isoforms in the senescence response to CDK4/6i. …”
Publicado 2022
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5094por Zhang, Yujing, Yang, Gang, Huang, Shuai, Yang, Xinyue, Yuan, Fengyan, Song, Yinghui, Liu, Sulai, Yu, Xing“…Stress-induced premature senescence may be involved in the pathogeneses of acute liver injury. …”
Publicado 2022
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5095por Kim, Hyun-Jung, Kim, Woo-Jin, Shin, Hye-Rim, Yoon, Hee-In, Moon, Jae-I, Lee, Eunji, Lim, Jin-Muk, Cho, Young-Dan, Lee, Mi-Hye, Kim, Hong-Gee, Ryoo, Hyun-Mo“…Cellular senescence is closely related to tissue aging including bone. …”
Publicado 2022
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5096por Chen, Ajuan, Jin, Jian, Cheng, Shasha, Liu, Zezheng, Yang, Cheng, Chen, Qingjing, Liang, Wenquan, Li, Kai, Kang, Dawei, Ouyang, Zhicong, Yao, Chenfeng, Bai, Xiaochun, Li, Qingchu, Jin, Dadi, Huang, Bin“…Senescence impairs preosteoblast expansion and differentiation into functional osteoblasts, blunts their responses to bone formation-stimulating factors and stimulates their secretion of osteoclast-activating factors. …”
Publicado 2022
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5097por Tamai, Motoki, Tatarano, Shuichi, Okamura, Shunsuke, Fukumoto, Wataru, Kawakami, Issei, Osako, Yoichi, Sakaguchi, Takashi, Sugita, Satoshi, Yonemori, Masaya, Yamada, Yasutoshi, Nakagawa, Masayuki, Enokida, Hideki, Yoshino, Hirofumi“…Furthermore, β‐galactosidase staining showed that miR‐99a‐5p induction and SMARCD1 suppression contributed to cellular senescence. In summary, tumor‐suppressive miR‐99a‐5p induced cellular senescence in gemcitabine‐resistant bladder cancer cells by targeting SMARCD1.…”
Publicado 2022
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5098por Huart, Camille, Fransolet, Maude, Demazy, Catherine, Le Calvé, Benjamin, Lucas, Stéphane, Michiels, Carine, Wéra, Anne-Catherine“…It has been recently demonstrated that senescence contributes to radioresistance. Cellular senescence is a permanent arrest in cell proliferation induced by various factors, such as radiation. …”
Publicado 2022
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5099por Ding, Xiaochun, Zhang, Dandan, Gu, Dachuan, Li, Zhiwei, Liang, Hanzhi, Zhu, Hong, Jiang, Yueming, Duan, Xuewu“…Leaf senescence is a highly-programmed developmental process during the plant life cycle. …”
Publicado 2022
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5100“…Butorphanol tartrate attenuated the TNF-α-caused cellular senescence of HC-A cells, with decreased positive senescence-associated-β-galactosidase (SA-β-gal) staining and elevated telomerase activity. …”
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