“…Asthma is a heterogeneous chronic respiratory disease that impacts nearly 10% of the population worldwide. While cellular senescence is a normal physiological process, the accumulation of senescent cells is considered a trigger that transforms physiology into the pathophysiology of a tissue/organ. …”
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“…The study of aging and its mechanisms, such as cellular senescence, has provided valuable insights into age-related pathologies, thus contributing to their prevention and treatment. …”
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“…The dysregulation of iron metabolism has also been observed in senescent cells, but in this case, our knowledge is still expanding. …”
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“…Moreover, both the roles of extracellular vesicles in stress-induced senescence and as an early detection marker for Alzheimer’s disease are considered. …”
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“…Meanwhile, the influence of QJMM granule on cell proliferation, oxidative stress, cellular senescence and the expression of the cellular senescence-associated genes were measured by corresponding methods. …”
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“…Accumulation of senescent cells impairs beta cell function and worsens the prognosis of diabetes. …”
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“…Recent studies gave some clues that PBUTs may also promote senescence in kidney tubular cells. This review provides an overview on how senescence contributes to CKD, the involvement of PBUTs in this process, and how kidney senescence can be studied. …”
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“…Most notably, ML has been used to aid the classification of cells as senescent, as well as to characterise the final senescence phenotypes. …”
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“…A growing body of evidence indicates an accumulation of senescent neurons and blood vessels in response to stress and aging in the retina. …”
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“…Congenital and acquired defects in mitochondria are responsible for several pathologies, including premature entrance to cellar senescence. Conversely, we examined the consequences of dysfunctional telomere‐driven cellular senescence on mitochondrial biogenesis and function. …”
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“…Cellular senescence refers to an irreversible state of cell-cycle arrest and plays important roles in aging and cancer biology. …”
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“…Given the global aging population and the role of cellular senescence in tissue and organ aging, understanding the impact of cellular senescence on PF is of growing interest. …”
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“…Tumor suppressor genes p53/pRB/p16INK4A and related senescence checkpoints are involved in effecting the onset of senescence. …”
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“…Cellular senescence is a tumor-suppressing mechanism that is accompanied by characteristic chromatin condensation called senescence-associated heterochromatic foci (SAHFs). …”
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“…Across a realistic spectrum of senescent age profiles, density regulation of recruitment can trigger runaway selection for ever-reducing senescence. …”
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“…Sensitivity of melanoma cells was associated with p53-dependent G2/M cell cycle arrest and induction of senescence. To verify the role of p53, the assays were repeated in presence of pifithrin-α, an inhibitor of p53. …”
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“…In this review, we survey the cellular state of senescence, review its causes, and describe associations with ageing and cancer. …”
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“…SIGNIFICANCE: Results affirm that deteriorating mitochondrial gene expression is a common theme in senescence, but also highlight novel pathways and features of gene architecture that may be important for understanding the molecular consequences of aging.…”
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“…Finally, PPP1CA seems to strongly co-localize with pRb only during senescence, suggesting that PP1α activation during senescence may be the second signal contributing to the irreversibility of the senescent phenotype.…”
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