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Mostrando 641 - 660 Resultados de 16,559 Para Buscar '"senescal"', tiempo de consulta: 0.24s Limitar resultados
  1. 641
    por Akbar, A. N.
    Publicado 2016
    “…This paper summarizes recent data identifying a convergence of senescence and nutrient signalling pathways in lymphocytes that inhibit both T cell and natural killer (NK) cell function during ageing. …”
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    The convergence of senescence and nutrient sensing during lymphocyte ageing
  2. 642
    “…The HFP results also showed a significant correlation with age, consistent with senescent increases in short wavelength absorption by the crystalline lens. …”
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    Senescent Changes and Topography of the Dark-Adapted Multifocal Electroretinogram
  3. 643
    “…In a cell autonomous fashion, IL-6 participates in oncogene-induced senescence in transduced human melanocytes. Here we prove that autocrine IL-6 participates in pituitary tumor senescence. …”
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    Autocrine IL-6 mediates pituitary tumor senescence
  4. 644
    “…In this review, we discuss the causes and consequences of cellular senescence, and the associated biological challenges in cartilage repair. …”
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    Cellular senescence in aging and osteoarthritis: Implications for cartilage repair
  5. 645
    por Charlton, Bruce G
    Publicado 1996
    “…This may provide a new and potentially fruitful approach to framing, analysing and understanding the aetiology of the degenerative diseases of senescence.…”
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    Senescence, Cancer and 'Endogenous Parasites': A Salutogenic Hypothesis
  6. 646
    por Salmonowicz, Hanna, Passos, João F.
    Publicado 2017
    “…Cellular senescence is a state of irreversible cell cycle arrest induced by different types of cellular stresses. …”
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    Detecting senescence: a new method for an old pigment
  7. 647
    “…Senescent cells contribute to age-related tissue degeneration. …”
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    Cellular senescence drives age-dependent hepatic steatosis
  8. 648
    por Yang, Leixiang, Fang, Jia, Chen, Jiandong
    Publicado 2017
    “…Tumors often respond favorably to initial chemotherapy but eventually relapse with drug resistance and increased metastatic potential. Cellular senescence is a major therapeutic outcome of cancer chemotherapy, which leads to tumor stasis or regression through immune clearance of senescent cells. …”
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    Tumor cell senescence response produces aggressive variants
  9. 649
    “…Cellular senescence has traditionally been viewed as a barrier to tumorigenesis. …”
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    The Potential Role of Senescence As a Modulator of Platelets and Tumorigenesis
  10. 650
    por Kubiak, Marco, Tinsley, Matthew C.
    Publicado 2017
    “…However, the extent to which senescent elevations in infection mortality are causally driven by deteriorations in canonical systemic immune processes is unclear. …”
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    Sex-Specific Routes To Immune Senescence In Drosophila melanogaster
  11. 651
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    Dysregulation of mTORC1/autophagy axis in senescence
  12. 652
    “…MeCP2, another important epigenetic regulator, is involved in regulating many life-related activities such as cell growth, death and senescence. Here we aim to explore the effect of MeCP2 on the functional activities of senescent EPCs and the underlying mechanisms. …”
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    MeCP2 mediated dysfunction in senescent EPCs
  13. 653
    “…Ezh2 maintains the repression of key cell senescence inducer genes through H3K27me3, and deletion of Ezh2 in early pubertal mice results in premature cellular senescence, depleted MSPCs pool, and impaired osteogenesis as well as osteoporosis in later life. …”
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    Programmed cell senescence in skeleton during late puberty
  14. 654
    “…In this manuscript, we review current knowledge regarding (1) the senescent cellular background, which is associated with a higher risk of genomic destabilization; and (2) the contributions of genomic destabilization to cancer development.…”
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    Genomic Destabilization Triggered by Replication Stress during Senescence
  15. 655
    “…Cellular senescence is a tumor suppressive response that has become recognized as a major contributor of tissue aging. …”
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    Epigenetic Basis of Cellular Senescence and Its Implications in Aging
  16. 656
    “…The accumulation of senescent cells is implicated in the pathology of several age-related diseases. …”
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    Ascorbic Acid Attenuates Senescence of Human Osteoarthritic Osteoblasts
  17. 657
    por Saab, Raya
    Publicado 2010
    “…Cellular senescence is a tumor-suppressor mechanism that has been shown to occur in response to multiple signals, including oncogenic stress, DNA damage, oxidative stress, telomere shortening, and other tumor-promoting insults. …”
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    Cellular Senescence: Many Roads, One Final Destination
  18. 658
    “…Accumulated evidence indicates that circadian genes regulate cell damage and senescence in most mammals. Endoplasmic reticulum (ER) stress and reactive oxygen species (ROS) regulate longevity in many organisms. …”
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    Clock mediates liver senescence by controlling ER stress
  19. 659
    “…OBJECTIVE: T-cells are critical players in the pathogenesis of osteoporosis in patients with rheumatoid arthritis (RA). Premature senescence of lymphocytes including the accumulation of senescent CD4(+) T-cells is a hallmark feature of RA. …”
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    Senescent T-Cells Promote Bone Loss in Rheumatoid Arthritis
  20. 660
    “…Senescent cells undergo irreversible growth arrest, usually by inducing telomere shortening. …”
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    IGF Binding Protein-5 Induces Cell Senescence
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