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681
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682por Wang, Ying, Liu, Jun, Ma, Xiaowei, Cui, Chao, Deenik, Philip R., Henderson, Paul K. P., Sigler, Ashton L., Cui, Lina“…Detection of cellular senescence is important not only in the study of senescence in various biological systems, but also in various practical applications such as image-guided surgical removal of senescent cells, as well as the monitoring of drug-responsiveness during cancer therapies. …”
Publicado 2019
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683“…Unlike replicative senescence associated with telomere attrition, premature senescence rapidly occurs in response to various intrinsic and extrinsic insults. …”
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684por Nacarelli, Timothy, Lau, Lena, Fukumoto, Takeshi, Zundell, Joseph, Fatkhutdinov, Nail, Wu, Shuai, Aird, Katherine M., Iwasaki, Osamu, Kossenkov, Andrew V., Schultz, David, Noma, Ken-ichi, Baur, Joseph A., Schug, Zachary, Tang, Hsin-Yao, Speicher, David W., David, Gregory, Zhang, Rugang“…Cellular senescence is a stable growth arrest that is implicated in tissue ageing and cancer. …”
Publicado 2019
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685por Fafián-Labora, Juan, Carpintero-Fernández, Paula, Jordan, Samuel James Davison, Shikh-Bahaei, Tamanna, Abdullah, Sana Mohammad, Mahenthiran, Midusa, Rodríguez-Navarro, José Antonio, Niklison-Chirou, Maria Victoria, O’Loghlen, Ana“…Senescent cells accumulate in several tissues during ageing and contribute to several pathological processes such as ageing and cancer. …”
Publicado 2019
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686por Lewis‐McDougall, Fiona C., Ruchaya, Prashant J., Domenjo‐Vila, Eva, Shin Teoh, Tze, Prata, Larissa, Cottle, Beverley J., Clark, James E., Punjabi, Prakash P., Awad, Wael, Torella, Daniele, Tchkonia, Tamara, Kirkland, James L., Ellison‐Hughes, Georgina M.“…SASP factors secreted by senescent CPCs renders otherwise healthy CPCs to senescence. …”
Publicado 2019
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687por He, Haiwei, Yu, Baoqi, Liu, Zipeng, Ye, Gen, You, Wei, Hong, Yimei, Lian, Qizhou, Zhang, Yuelin, Li, Xin“…RNA sequencing showed that several cellular process‐related pathways including cell cycle and cellular senescence were significantly enriched in MFP‐VPCs. …”
Publicado 2019
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688por Boichuck, Maria, Zorea, Jonathan, Elkabets, Moshe, Wolfson, Marina, Fraifeld, Vadim E.“…This suggests that c-Met could serve as an early marker of cellular senescence (CS). The levels of c-Met-related signaling proteins phospho-Akt and Stat3 were also increased in (pre)senescent fibroblasts. …”
Publicado 2019
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689“…A major recent development in the senescence field has been the creation of mouse models which allow the specific elimination of senescent cells. …”
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690por Knoppert, Sebastian N., Valentijn, Floris A., Nguyen, Tri Q., Goldschmeding, Roel, Falke, Lucas L.“…The clearance of senescent cells in aging models results in improved kidney function, which shows promise for the options of targeting senescent cells in CKD. …”
Publicado 2019
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691por Lau, E. Y. M., Carroll, E. C., Callender, L. A., Hood, G. A., Berryman, V., Pattrick, M., Finer, S., Hitman, G. A., Ackland, G. L., Henson, S. M.“…Type 2 diabetes is a global health priority, given that it is driven, in part, by an ageing population, the role of immune senescence has been overlooked. This is surprising, as the functional impairments of senescent T cells show strong similarities to patients with hyperglycaemia. …”
Publicado 2019
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692por Deng, Liping, Ren, Ruotong, Liu, Zunpeng, Song, Moshi, Li, Jingyi, Wu, Zeming, Ren, Xiaoqing, Fu, Lina, Li, Wei, Zhang, Weiqi, Guillen, Pedro, Izpisua Belmonte, Juan Carlos, Chan, Piu, Qu, Jing, Liu, Guang-Hui“…An N-terminal-truncated version of DGCR8 (DR8(dex2)) accelerated senescence in human mesenchymal stem cells (hMSCs) independent of its microRNA-processing activity. …”
Publicado 2019
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693por Li, Mingde, Yao, Danlin, Zeng, Xiangbo, Kasakovski, Dimitri, Zhang, Yikai, Chen, Shaohua, Zha, Xianfeng, Li, Yangqiu, Xu, LingEnlace del recurso
Publicado 2019
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694por Gal, Hilah, Lysenko, Marina, Stroganov, Sima, Vadai, Ezra, Youssef, Sameh A, Tzadikevitch‐Geffen, Keren, Rotkopf, Ron, Biron‐Shental, Tal, de Bruin, Alain, Neeman, Michal, Krizhanovsky, Valery“…To elucidate the functions of pathways regulating senescence in syncytiotrophoblast, we used dynamic contrast‐enhanced MRI in mice with attenuated senescence programs. …”
Publicado 2019
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695por Schmid, Nina, Flenkenthaler, Florian, Stöckl, Jan B., Dietrich, Kim-Gwendolyn, Köhn, Frank M., Schwarzer, J. Ullrich, Kunz, Lars, Luckner, Manja, Wanner, Gerhard, Arnold, Georg J., Fröhlich, Thomas, Mayerhofer, Artur“…Consequences of replicative senescence of HTPCs were evaluated to gain partial insights into human testicular aging. …”
Publicado 2019
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696“…Senescent cells provide a good in vitro model to study ageing. …”
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697por Schafer, Marissa, Zhang, Xu, Kumar, Amanika, White, Thomas, Atkinson, Elizabeth, Burning, Michelle, LeBrasseur, Nathan“…Senescent cells drive age-related tissue dysfunction through their potent secretome, termed the senescence associated secretory phenotype (SASP). …”
Publicado 2019
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698por Schmeer, Christian, Kretz, Alexandra, Wengerodt, Diane, Stojiljkovic, Milan, Witte, Otto W.“…Similarly unanswered are the questions of whether aging is reversible and can be turned into rejuvenation as well as how aging is distinguishable from and influenced by cellular senescence. With the discovery of beneficial aspects of cellular senescence and evidence of senescence being not limited to replicative cellular states, a redefinition of our comprehension of aging and senescence appears scientifically overdue. …”
Publicado 2019
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699por Sabbatinelli, Jacopo, Prattichizzo, Francesco, Olivieri, Fabiola, Procopio, Antonio Domenico, Rippo, Maria Rita, Giuliani, Angelica“…Despite the decline in their proliferative potential, senescent cells display a high metabolic activity. …”
Publicado 2019
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700por Lu, Jingyun, Xu, Yanjie, Fan, Youwei, Wang, Yaru, Zhang, Guifang, Liang, Yue, Jiang, Chuyan, Hong, Bo, Gao, Junping, Ma, Chao“…Petal senescence involves numerous programmed changes in biological and biochemical processes. …”
Publicado 2019
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