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  1. 721
    “…Based on findings in animal models that tau pathology induces vascular abnormalities and cellular senescence, we hypothesized that tau pathology in the human AD brain leads to vascular senescence. …”
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    Cerebrovascular Senescence Is Associated With Tau Pathology in Alzheimer's Disease
  2. 722
    “…We aimed to investigate the role of senescence in DMD using DMD rats and patients. Senescence was induced in satellite cells and mesenchymal progenitor cells, owing to the increased expression of CDKN2A, p16- and p19-encoding gene. …”
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    Cellular senescence-mediated exacerbation of Duchenne muscular dystrophy
  3. 723
    “…In our previous studies, we identified HDAC4, JMJD3, Fra-1, and GATA4 as potential pharmacological targets for regulating vascular inflammation, injury, and senescence.…”
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    Epigenetics and Vascular Senescence–Potential New Therapeutic Targets?
  4. 724
    “…Exosomes are involved in multiple physiological and pathological processes, including cellular senescence. Exosomes mediate signaling crosstalk and play a critical role in cell–cell communications. …”
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    Nano-Vesicle (Mis)Communication in Senescence-Related Pathologies
  5. 725
    por Frisch, Steven M., MacFawn, Ian P.
    Publicado 2020
    “…Here, we critically address the bidirectional interplay between interferons (focusing on type I) and cell senescence, with important implications for health and healthspan.…”
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    Type I interferons and related pathways in cell senescence
  6. 726
    “…Cellular senescence is characterized by stable cell cycle arrest and a secretory program that modulates the tissue microenvironment(1,2). …”
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    Senolytic CAR T cells reverse senescence-associated pathologies
  7. 727
    “…Cellular senescence is considered a stress response imposing a stable cell cycle arrest to restrict the growth of damaged cells. …”
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    Developmentally-programmed cellular senescence is conserved and widespread in zebrafish
  8. 728
    por Goliwas, Kayla F., Deshane, Jessy S.
    Publicado 2020
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    Extracellular Vesicles: Bidirectional Accelerators of Cellular Senescence in Fibrosis?
  9. 729
    por Maeda, Hidefumi
    Publicado 2020
    “…With advancing age, these tissues become senescent; each tissue exhibits a unique senescent pattern. …”
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    Aging and Senescence of Dental Pulp and Hard Tissues of the Tooth
  10. 730
    “…Thus, like other cell processes, cellular senescence is unequal between males and females and CR delays the emergence of the senescence phenotype.…”
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    Uncovering the Molecular Underpinnings of Oxidative Stress-Induced Senescence
  11. 731
    por Kirkland, James
    Publicado 2020
    “…Senescent cells (SC) accumulate with aging and at causal sites of multiple chronic disorders and diseases, including those accounting for the bulk of morbidity, mortality, and health expenditures. …”
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    Aging, Senescent Cells, and Senolytic Drugs: The Path to Translation
  12. 732
    “…Cellular senescence permanently arrests the replication of various cell types and contributes to age-associated diseases. …”
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    Cellular senescence: friend or foe to respiratory viral infections?
  13. 733
    “…Targeting MRTFs results in HCC growth arrest provoked by oncogene-induced senescence. The induction of senescence acts as a tumor-suppressive mechanism and therefore gains consideration for pharmacological interventions in cancer therapy. …”
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    Molecular Mechanisms to Target Cellular Senescence in Hepatocellular Carcinoma
  14. 734
    “…Accumulation of senescent cells is an important contributor to chronic inflammation upon aging. …”
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    Reduced RNA turnover as a driver of cellular senescence
  15. 735
    Materias: “…DNA Damage, Cellular Senescence and Human Aging (Ed. Manlio Vinciguerra)…”
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    Senescence in Post-Mitotic Cells: A Driver of Aging?
  16. 736
    por Wu, Kenneth K.
    Publicado 2021
    “…Cellular senescence contributes to aging and age-related disorders. …”
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    Control of Mesenchymal Stromal Cell Senescence by Tryptophan Metabolites
  17. 737
    “…Recent findings have proven that cellular senescence is more than that. A specific grade of senescence promotes embryo development, tissue remodeling and wound healing. …”
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    Bcl-xL as a Modulator of Senescence and Aging
  18. 738
    por Ernst, Philipp, Heidel, Florian H.
    Publicado 2021
    “…SIMPLE SUMMARY: Senescence is a cellular program in response to stress and can prevent the expansion of pre-malignant and malignant cells by cell cycle arrest. …”
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    Molecular Mechanisms of Senescence and Implications for the Treatment of Myeloid Malignancies
  19. 739
    “…Moreover, POLD1 is downregulated in replicative senescence to mediate aging. In any case, the components of age-related downregulation of POLD1 expression have not been fully explained. …”
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    CTCF Mediates Replicative Senescence Through POLD1
  20. 740
    “…Recent data suggest that senescence and autophagy might play a role in its development, as well as changes in metabolism due to hypoxic conditions. …”
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    Senescence and autophagy in usual interstitial pneumonia of different etiology
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