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  1. 741
    “…Herein, we discuss the implications of SIRT6 regulates multiple cellular processes in cell senescence and aging-related CVDs, and we summarize clinical application of SIRT6 agonists and possible therapeutic interventions in aging-related CVDs.…”
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    SIRT6 in Senescence and Aging-Related Cardiovascular Diseases
  2. 742
    por Karin, Omer, Alon, Uri
    Publicado 2020
    “…Senescent cells are growth-arrested cells that cause inflammation and play a causal role in aging. …”
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    Senescent cell accumulation mechanisms inferred from parabiosis
  3. 743
    “…Leaf senescence is an integrated response of the cells to develop age information and various environmental signals. …”
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    The Role of Light and Circadian Clock in Regulation of Leaf Senescence
  4. 744
    “…Tumor senescence can be categorized into replicative senescence and premature senescence. …”
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    Possibility of inducing tumor cell senescence during therapy
  5. 745
    “…In transplantation, donor and recipients frequently differ in age. Senescent cells accumulate in donor organs with aging and have the potential to promote senescence in adjacent cells when transferred into recipient animals. …”
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    Donor and Recipient Age-Mismatches: The Potential of Transferring Senescence
  6. 746
    por Mohiuddin, Md, Kasahara, Kazuo
    Publicado 2021
    “…We hypothesize that side effects of chemotherapy, such as cellular senescence, could worsen COVID-19. Given this situation, in this review, we highlight the updated findings of research investigating the impact of cellular senescence on COVID-19 complications and explored potential therapeutic targets for eliminating senescent cells during the COVID-19 pandemic.…”
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    The emerging role of cellular senescence in complications of COVID-19
  7. 747
    por Riessland, Markus
    Publicado 2021
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    Cellular Senescence in Health, Disease and Aging: Blessing or Curse?
  8. 748
    “…In this review, we examine senescent cells and the overlap between the direct biological impact of senescence and the indirect impact senescence has via its effects on other cell types, particularly the macrophage. …”
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    The Role of Ageing and Parenchymal Senescence on Macrophage Function and Fibrosis
  9. 749
    “…Senescent cells exhibit a reduced response to intrinsic and extrinsic stimuli. …”
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    Disruption of nucleocytoplasmic trafficking as a cellular senescence driver
  10. 750
    “…Due to the increase in the aged population and increased life expectancy, the underlying mechanisms involved in the aging process and cell senescence and the ways for modulating these processes in age-related diseases become important. …”
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    Trends in Natural Nutrients for Oxidative Stress and Cell Senescence
  11. 751
    “…Cellular senescence has emerged as a significant and potentially tractable mechanism of aging and multiple aging‐related conditions. …”
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    Exercise reduces circulating biomarkers of cellular senescence in humans
  12. 752
    “…We further demonstrate that KL expression alters the expression of senescence-associated genes including, extracellular matrix genes, and proteoglycans, and can act in a paracrine fashion to inhibit neuronal senescence. …”
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    Klotho inhibits neuronal senescence in human brain organoids
  13. 753
    “…Recent studies in Arabidopsis (Arabidopsis thaliana) have reported conflicting roles for NAC DOMAIN CONTAINING PROTEIN 17 (ANAC017), a transcription factor regulating mitochondria-to-nuclear signaling, and its closest paralog NAC DOMAIN CONTAINING PROTEIN 16 (ANAC016), in leaf senescence. By synchronizing senescence in individually darkened leaves of knockout and overexpressing mutants from these contrasting studies, we demonstrate that elevated ANAC017 expression consistently causes accelerated senescence and cell death. …”
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    Increased expression of ANAC017 primes for accelerated senescence
  14. 754
    “…Cellular senescence is characterized as a stable proliferation arrest that can be triggered by multiple stresses. …”
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    The Cancer SENESCopedia: A delineation of cancer cell senescence
  15. 755
    “…ZNF768 levels decrease in response to replicative-, stress- and oncogene-induced senescence. Interestingly, ZNF768 overexpression contributes to bypass RAS-induced senescence by repressing the p53 pathway. …”
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    ZNF768 links oncogenic RAS to cellular senescence
  16. 756
    “…We hypothesized that senescent cells (SnCs) play a central role in this age-associated pathology in part due to their expression of the senescence-associated secretory phenotype (SASP), which may prime SnCs to inflammatory stimulation. …”
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    Senescence-associated hyper-activation to inflammatory stimuli in vitro
  17. 757
    “…An accumulation of senescence and increased inflammation, caused by the senescence-associated secretory phenotype, have been implicated in the aetiology and progression of these age-associated diseases. …”
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    Senescence and senolytics in cardiovascular disease: Promise and potential pitfalls
  18. 758
    “…Inhibition of cell senescence may help identify new agents with the properties of DMOADs. …”
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    Aging, Cell Senescence, the Pathogenesis and Targeted Therapies of Osteoarthritis
  19. 759
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    Correction to ‘SIRT3 consolidates heterochromatin and counteracts senescence’
  20. 760
    “…For this reason, we herein present an in vitro model of the senescent BBB and an initial attempt to identify senescence-associated alterations within.…”
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    Senescence and associated blood–brain barrier alterations in vitro
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