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  1. 761
    “…SIMPLE SUMMARY: Senescence is a form of cell cycle arrest induced by stresses such as DNA damage and oncogenes and therefore constitutes a crucial barrier against cancer. …”
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    Cellular Plasticity: A Route to Senescence Exit and Tumorigenesis
  2. 762
    “…The cause of this abnormal accumulation of senescent cells is unknown but evidence suggests that, once established, senescence can be transferred from senescent to non-senescent cells. …”
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    A Senescence Bystander Effect in Human Lung Fibroblasts
  3. 763
    “…Cellular senescence is an essential tumor suppressive mechanism that prevents the propagation of oncogenically activated, genetically unstable, and/or damaged cells. …”
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    Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy
  4. 764
    “…Alveolar epithelial cells (ACEs) gradually senescent as aging, which is one of the main causes of respiratory defense and function decline. …”
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    Nicotinamide mononucleotide ameliorates senescence in alveolar epithelial cells
  5. 765
    “…However, determining the presence of senescent cells would require invasive procedures such as tissue biopsies to be taken. …”
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    Extracellular matrix and cellular senescence in venous leg ulcers
  6. 766
    “…Emerging research suggests DNA damage-induced cellular senescence as a possible driver of mTBI-related sequalae. …”
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    Cellular Senescence in Traumatic Brain Injury: Evidence and Perspectives
  7. 767
    “…However, the potential role of senescent cells in fracture healing has not been defined. …”
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    Modulation of fracture healing by the transient accumulation of senescent cells
  8. 768
    “…Innate immune system dysfunction that leads to decreased senescent cell removal and/or increased senescent cell formation could contribute to accumulation of senescent cells with both aging and viral infections. …”
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    Role of senescence in the chronic health consequences of COVID-19
  9. 769
    “…The study of cell senescence is a burgeoning field. Senescent cells can modify the cellular microenvironment through the secretion of a plethora of biologically active products referred to as the senescence‐associated secretory phenotype (SASP). …”
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    Cell senescence in neuropathology: A focus on neurodegeneration and tumours
  10. 770
    “…Here we discuss this idea in light of recent advances supporting an interplay between MERCs, cellular senescence and aging.…”
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    Cellular senescence links mitochondria-ER contacts and aging
  11. 771
    “…Mitochondria are one of organelles that undergo significant changes associated with senescence. An increase in mitochondrial size is observed in senescent cells, and this increase is ascribed to the accumulation of dysfunctional mitochondria that generate excessive reactive oxygen species (ROS). …”
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    Targeting Mitochondrial Metabolism as a Strategy to Treat Senescence
  12. 772
    “…Additionally, AA promoted cellular senescence specifically in the kidneys, and increased renal p16 mRNA expression and senescence-associated β-galactosidase activity. …”
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    Aristolochic Acid Induces Renal Fibrosis and Senescence in Mice
  13. 773
    “…Cellular senescence underlies tissue aging and aging-associated pathologies, as well as lung pathology. …”
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    Protocol for assessing senescence-associated lung pathologies in mice
  14. 774
    “…Both in vitro cellular models of endothelial cell dysfunction-associated senescence developed in this study, starvation and oxidative stress, were validated by markers of cellular senescence (increase in β-galactosidase activity, and changes in senescence gene markers SIRT1 and P21) and endothelial dysfunction as denoted by reductions in angiogenic and migratory capabilities. …”
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    Linking In Vitro Models of Endothelial Dysfunction with Cell Senescence
  15. 775
    “…Finally, we summarize the emerging pro-senescent or anti-senescent interventions and discuss their therapeutic potential in preventing cardiovascular diseases.…”
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    Cellular Senescence in Cardiovascular Diseases: A Systematic Review
  16. 776
    “…More efforts have been made to clarify mechanisms underlying sarcopenia and new findings suggest that it may be feasible to delay age-related sarcopenia by modulating fundamental mechanisms such as cellular senescence. Cellular senescence refers to the essentially irreversible growth arrest mainly regulated by p53/p21(CIP1) and p16(INK4a)/pRB pathways as organism ages, possibly detrimentally contributing to sarcopenia via muscle stem cells (MuSCs) dysfunction and the senescence-associated secretory phenotype (SASP) while cellular senescence may have beneficial functions in counteracting cancer progression, tissue regeneration and wound healing. …”
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    Cellular Senescence in Sarcopenia: Possible Mechanisms and Therapeutic Potential
  17. 777
    “…Owing to an increase in studies on cellular senescence in recent years, research has begun to focus on the function of the senescent microenvironment in osteoporosis. …”
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    The Role of Senescence-Associated Secretory Phenotype in Bone Loss
  18. 778
    “…However, non-invasive biomarkers to detect early kidney damage and the onset of a senescent phenotype are lacking. Most of the preclinical senescence studies in aging have been done in very old mice. …”
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    Oxidative Stress and Cellular Senescence Are Involved in the Aging Kidney
  19. 779
    “…Although effective in providing local tumor control, radiation causes oxidative stress, inflammation, immunomodulatory and mitogenic cytokine production, extracellular matrix production, and premature senescence in lung parenchyma. The senescence associated secretory phenotype (SASP) can promote inflammation and stimulate alterations in the surrounding tissue. …”
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    Senescence-associated tumor growth is promoted by 12-Lipoxygenase
  20. 780
    “…Although senescence has been considered as an irreversible cell arrest state, accumulating evidence challenge this view. …”
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    Escape from senescence: revisiting cancer therapeutic strategies
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