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“…Cellular senescence is defined as irreversible cell cycle arrest caused by various processes that render viable cells non-functional, hampering normal tissue homeostasis. …”
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“…Hydra are remarkable because they are non-senescent. Much of this non-senescence can be ascribed to a tissue consisting of stem cells with continuous self-renewal capacity. …”
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“…Emerging studies have revealed that cellular senescence and abnormal glucose metabolism in the brain are the early hallmarks of AD. …”
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“…Cellular senescence is a process, which may play two opposite roles. …”
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“…Although the importance of astrocytes is generally recognized, and both senescence and reactive astrogliosis have been extensively reviewed independently, there are only a few comparative overviews of these complex processes. …”
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“…However, the damage also induces cellular senescence. Here, we show that not apoptosis, but cellular senescence is the main response triggered by TMZ-induced DNA damage. …”
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“…We found that the glucosinolate biosynthetic pathway coincided with the progression of senescence in postharvest broccoli during storage. Additionally, we applied machine learning-based hyperspectral image (HSI) analysis, unmixing, and subpixel target detection approaches to evaluate glucosinolate level to detect postharvest senescence in broccoli. …”
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“…BACKGROUNDS: Many factors are involved in cellular aging, and senescence induction requires complex regulation of various signaling networks and processes. …”
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“…Senescence is a specialized form of cell cycle arrest induced in response to damage and stress. …”
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“…BACKGROUND: Flower senescence is the last stage of flower development and affects the ornamental and economic value of flower plants. …”
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“…We postulate that to unravel the relationship between inflammation and senescence in PD, it is crucial to first understand the potential causative roles of various cell types of the midbrain and determine how the possible paracrine spreading of senescence between them may lead to observed local immune responses. …”
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“…Over the past two decades, mounting evidence suggests an accumulation of senescent cells within the lungs of patients with COPD that contributes to dysregulated tissue repair and the secretion of multiple inflammatory proteins, termed the senescence-associated secretory phenotype (SASP). …”
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“…Therefore, we will discuss cellular alterations in aging, concentrating on senescent T cells and CD4+ CD25+ FOXP3+ regulatory T cells (Tregs) in aging…”
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“…In the light of this, interest in the detection of senescent cells in different tissues and different species is increasing. …”
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“…With ageing, unconventional end-stage T cells, that exhibit a senescent phenotype, amass. These senescent T cells deviate from T cell receptor (TCR) signaling toward natural killer (NK) activity. …”
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“…Cell culture models are valuable tools to investigate the mechanisms of aging by inducing cellular senescence in stress-induced premature senescence (SIPS) models. …”
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“…Senescence is a stress-response process characterized by the irreversible inhibition of cell proliferation, associated to the acquisition of a senescence-associated secretory phenotype (SASP), that may drive pathological conditions. …”
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“…Cellular senescence is an irreversible state of cell cycle arrest occurring in response to stressful stimuli, such as telomere attrition, DNA damage, reactive oxygen species, and oncogenic proteins. …”
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