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  1. 821
    “…The role of senescence in mediating muscle aging has become a popular and sometimes contentious topic. …”
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    IDENTIFICATION AND INVESTIGATION OF SENESCENT CELLS IN SKELETAL MUSCLE AGING
  2. 822
    “…Aging is a complex biological process associated with progressive loss of physiological function and susceptibility to several diseases, such as cancer and neurodegeneration. As senescence burden increases with aging and becomes a risk factor for many age-related diseases we are specifically interested in senescence-derived aging signatures. …”
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    SENESCENCE-DERIVED PROTEIN BIOMARKERS DURING AGING AND OSTEOARTHRITIS
  3. 823
    por Hughes, Bethany K., Bishop, Cleo L.
    Publicado 2022
    “…Senescent cells can also be detrimental and contribute to skin ageing phenotypes through their senescence-associated secretory phenotype. …”
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    Current Understanding of the Role of Senescent Melanocytes in Skin Ageing
  4. 824
    “…Cellular senescence is a state of stable cell-cycle arrest with secretory features in response to cellular stress. …”
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    Cellular senescence in cancer: clinical detection and prognostic implications
  5. 825
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    Editorial: Systems biology of maturation and senescence in horticultural plants
  6. 826
    “…Although the mechanisms of myofibre loss in CKD has been widely studied, the contribution of muscle precursor cell (MPC) senescence remains poorly understood. Senescent MPCs no longer proliferate and can produce proinflammatory factors or cytokines. …”
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    The impact of senescence on muscle wasting in chronic kidney disease
  7. 827
    “…Cellular senescence involves a stable cell-cycle arrest coupled to a secretory program that, in some instances, stimulates the immune clearance of senescent cells. …”
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    Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity
  8. 828
    “…Senescent cells exhibit several typical features, including the senescence-associated secretory phenotype (SASP), promoting the secretion of various inflammatory proteins and small extracellular vesicles (EVs). …”
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    Identification of Novel Senescent Markers in Small Extracellular Vesicles
  9. 829
    “…Here we demonstrated Fas signaling-mediated premature senescence in young mouse embryonic fibroblast (MEF) cells. …”
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    A novel role of Fas in delaying cellular senescence
  10. 830
    por Jo, Hyein, Shim, Kyeonghee, Jeoung, Dooil
    Publicado 2023
    “…Senescence occurs in response to various stimuli. Senescence has attracted attention because of its potential use in anticancer therapy as it plays a tumor-suppressive role. …”
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    The Potential of Senescence as a Target for Developing Anticancer Therapy
  11. 831
    por Han, Shan, Lu, Qiangwei, Liu, Xiaoqiu
    Publicado 2023
    “…However, the mechanism by which aging promotes development of PF remains unclear. Senescence of alveolar epithelial cells and lung fibroblasts (LFs) and their senescence-associated secretion phenotype (SASP) may be involved in the occurrence and development of IPF. …”
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    Advances in cellular senescence in idiopathic pulmonary fibrosis (Review)
  12. 832
    por Gao, Pan, Yao, Feng, Pang, Jin, Yin, Kai, Zhu, Xiao
    Publicado 2023
    “…Cellular senescence is a state of irreversible cellular growth arrest that occurs in response to various stresses. …”
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    m (6)A methylation in cellular senescence of age-associated diseases : m (6)A methylation in cellular senescence of age-associated diseases
  13. 833
    “…The important role of c-Myc in bladder cancer cell senescence was determined using bioinformatics methods. …”
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    Senescence-related gene c-Myc affects bladder cancer cell senescence by interacting with HSP90B1 to regulate cisplatin sensitivity
  14. 834
    “…BACKGROUND: Senescent cells are well-recognized in the aging/degenerating human disc. …”
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    Senescent vs. non-senescent cells in the human annulus in vivo: Cell harvest with laser capture microdissection and gene expression studies with microarray analysis
  15. 835
    “…Single-cell analysis of noncancerous human fibroblast cultures undergoing senescence as a function of culture age (replicative senescence) has revealed that p16 is not expressed in the majority (>90%) of cells that exhibit features of senescence (e.g., flattened and enlarged morphology coupled with senescence-associated β-galactosidase expression), ruling out a requirement for p16 in this process. …”
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    Role of p16(INK4A) in Replicative Senescence and DNA Damage-Induced Premature Senescence in p53-Deficient Human Cells
  16. 836
    “…It is a highly regulated process, and in order to address the regulatory aspect, the role of genes in the NAC transcription factor family during senescence of barley flag leaves was studied. Several members of the NAC transcription factor gene family were up-regulated during senescence in a microarray experiment, together with a large range of senescence-associated genes, reflecting the coordinated activation of degradation processes in senescing barley leaf tissues. …”
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    Members of the barley NAC transcription factor gene family show differential co-regulation with senescence-associated genes during senescence of flag leaves
  17. 837
    “…Here we describe a panel of genetic screens to identify genes required for replicative senescence. We uncover a role in senescence for the potent tumor suppressor and ATM substrate USP28. …”
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    Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program
  18. 838
    “…Senescence of cancer cells is an important outcome of treatment of many cancer types. …”
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    Insight into the role of PIKK family members and NF-кB in DNAdamage-induced senescence and senescence-associated secretory phenotype of colon cancer cells
  19. 839
    “…Senescent cells display the senescence-associated secretory phenotype (SASP) which plays important roles in cancer, aging, etc. …”
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    S100A13 promotes senescence-associated secretory phenotype and cellular senescence via modulation of non-classical secretion of IL-1α
  20. 840
    “…Senescent cells display a senescence‐associated secretory phenotype (SASP) which contributes to tumor suppression, aging, and cancer. …”
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    hnRNP A1 antagonizes cellular senescence and senescence‐associated secretory phenotype via regulation of SIRT1 mRNA stability
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