“…Cellular senescence is an irreversible form of cell cycle arrest that has been linked to several pathological conditions. …”
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“…In addition, we refer to the molecular responses that are thought to be related to leaf senescence. With these current data, we give an overview of leaf senescence induced by Mg deficiency.…”
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“…Cellular senescence is a state of stable proliferation arrest of cells. …”
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“…In this review, we will focus on T cells and discuss the surface and molecular markers that are associated with T cell senescence. We will also look at the implications that senescent T cells could have on human health and diseases. …”
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“…The rate of senescence of the organism increases while the protecting energy decreases. …”
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“…As our understanding of the basic mechanisms of controlling mTORC1‐autophagy activity and cell growth continues to expand, we are able to explore how changes in nutrient sensing contribute to the acquisition and maintenance of cellular senescence. Furthermore, while the protective effect of senescence to limit cellular transformation is clear, more recently, the age‐related accumulation of these pro‐inflammatory senescent cells has been shown to contribute to a decline in organismal fitness. …”
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“…RPP is a potential of quiescent cells that is lost in senescent cells. mTOR drives conversion from quiescence to senescence (geroconversion). …”
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“…In addition to the core non-proliferative aspect, senescence is associated with diverse functionalities, which contribute to the role of senescence in a wide range of pathological and physiological processes. …”
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“…We discuss the significance of targeting senescent astrocytes as a novel approach toward therapies for age‐associated neurodegenerative disease.…”
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“…Cellular senescence refers to a stress response aiming to preserve cellular and, therefore, organismal homeostasis. …”
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“…Gradual alterations of cell’s physiology and functions due to age or exposure to various stresses lead to the conversion of normal cells to senescent cells. Once becoming senescent, the cell stops dividing permanently but remains metabolically active. …”
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“…We conclude that despite the decrease of miR-124-3p and miR-340-5p in senescent cells, their overexpression enhanced senescence as indicated by β-gal activity. …”
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“…Senescent cells drive aging. Preclinical studies suggest that targeted elimination of senescent cells offers a unique therapeutic approach to counter numerous chronic diseases and geriatric syndromes. …”
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“…The increased presence of senescent cells in different neurodegenerative diseases suggests the contribution of senescence in the pathophysiology of these disorders. …”
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“…Sea urchin longevity and senescence research is a new and promising field that holds promise for the understanding of aging in vertebrates and can increase our understanding of human longevity and of healthy aging.…”
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“…In addition to the irreversible termination of proliferation, senescent cells are characterized by a flattened and enlarged morphology. …”
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“…In this way, senescence can be considered a powerful innate defence against cancer and viral infection. …”
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