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  1. 981
    “…Experimental evidence indicates that aging leads to accumulation of senescent cells in tissues and they develop a secretory phenotype (also known as SASP, for senescence-associated secretory phenotype) that can contribute to chronic inflammation and diseases. …”
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    A Model for p38MAPK-Induced Astrocyte Senescence
  2. 982
    “…In model organisms reduced IIS extends lifespan and ameliorates some forms of functional senescence. However, little is known about IIS in nervous system ageing and behavioural senescence. …”
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    The Drosophila Insulin Receptor Independently Modulates Lifespan and Locomotor Senescence
  3. 983
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    Glucose metabolism and hexosamine pathway regulate oncogene-induced senescence
  4. 984
    “…Hydra represents a unique model system for the study of senescence, with the opportunity for the comparison of non-aging and induced senescence. …”
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    Hydra as a tractable, long-lived model system for senescence
  5. 985
    “…Human and mouse skin accumulate senescent cells in both the epidermis and dermis during aging. …”
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    Cell Autonomous and Non-autonomous Effects of Senescent Cells in the Skin
  6. 986
    “…Cellular senescence is a fundamental aging mechanism that has been implicated in many age-related diseases and is a significant cause of tissue dysfunction. …”
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    Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity
  7. 987
    “…Drugs targeting these same factors selectively killed senescent cells. Dasatinib eliminated senescent human fat cell progenitors, while quercetin was more effective against senescent human endothelial cells and mouse BM-MSCs. …”
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    The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
  8. 988
    “…However, it is not known if senescence is causally linked to either stiffness or SFRP1 expression. …”
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    The intrinsic stiffness of human trabecular meshwork cells increases with senescence
  9. 989
    “…Many studies have shown that intracellular level of p53 is enhanced during replicative senescence in normal fibroblasts, and the enhanced level of p53 is viewed as the cause of senescence. …”
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    Regulation of p53 during senescence in normal human keratinocytes
  10. 990
    “…Our aim was to assess whether menopause is associated with the severity of liver fibrosis in individuals with NAFLD and to explore the issue of ovarian senescence in experimental liver steatosis in zebrafish. …”
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    Ovarian senescence increases liver fibrosis in humans and zebrafish with steatosis
  11. 991
    “…In annual plants such as Arabidopsis thaliana senescence can be observed in each individual leaf. …”
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    Photosynthetic lesions can trigger accelerated senescence in Arabidopsis thaliana
  12. 992
    “…CONCLUSIONS: A microarray analysis about dark-induced miRNAs involved in leaf senescence are present here. Further expression analysis revealed that some new founding miRNAs maybe regulate leaf senescence in Arabidopsis, and the findings highlight the important role of miRNAs in dark-induced leaf senescence. …”
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    Identification of miRNAs associated with dark-induced senescence in Arabidopsis
  13. 993
    por Kumar, Ashok
    Publicado 2015
    “…The current review intends to present an overview of the research findings regarding changes in expression of various NMDA receptor subunits and deficits in NMDA receptor function during senescence and its implication in age-associated impaired hippocampal-dependent memory function.…”
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    NMDA Receptor Function During Senescence: Implication on Cognitive Performance
  14. 994
    “…We demonstrated that the interdigital dying process was associated with cell senescence, as deduced by induction of β-gal activity, mitotic arrest, and transcriptional up-regulation of p21 together with many components of the senescence-associated secretory phenotype. …”
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    Apoptosis during embryonic tissue remodeling is accompanied by cell senescence
  15. 995
    “…Cellular senescence, a state of essentially irreversible proliferation arrest, serves as a potent tumour suppressor mechanism. …”
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    Reversal of phenotypes of cellular senescence by pan-mTOR inhibition
  16. 996
    “…Cellular senescence is a stress response mechanism that limits tumorigenesis and tissue damage. …”
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    NKG2D ligands mediate immunosurveillance of senescent cells
  17. 997
    “…Furthermore, we describe that abolishing the MOZ HAT activity of the fusion protein leads to a significant increase in expression of the CDKN2A locus and the number of hematopoietic progenitors undergoing senescence. Finally, we report that inhibition of senescence by MOZ-TIF2 is associated with increased apoptosis, suggesting a role for the fusion protein in p53 apoptosis-versus-senescence balance. …”
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    Expression of the MOZ-TIF2 oncoprotein in mice represses senescence
  18. 998
    por Aldahmash, Abdullah
    Publicado 2015
    “…Recent studies are presented that have demonstrated that SSC exhibit impaired functions during aging due to intrinsic senescence-related changes as well as the presence of senescent microenvironment. …”
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    Skeletal stem cells and their contribution to skeletal fragility: senescence and rejuvenation
  19. 999
    “…Leaf senescence, being the final developmental stage of the leaf, signifies the transition from a mature, photosynthetically active organ to the attenuation of said function and eventual death of the leaf. …”
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    Molecular Mechanisms of Phosphorus Metabolism and Transport during Leaf Senescence
  20. 1000
    “…Biotrophic pathogens often delay senescence to keep host cells alive, and resistance is achieved by senescence-like processes in the host. …”
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    Keeping Control: The Role of Senescence and Development in Plant Pathogenesis and Defense
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