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  1. 1041
    “…Upon telomerase inactivation, telomeres gradually shorten with each cell division until cells enter replicative senescence. In Saccharomyces cerevisiae, the kinases Mec1/ATR and Tel1/ATM protect the genome during pre-senescence by preventing telomere-telomere fusions (T-TFs) and the subsequent genetic instability associated with fusion-bridge-breakage cycles. …”
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    Histone depletion prevents telomere fusions in pre-senescent cells
  2. 1042
    “…Among others, senescent cells are able to transform tissue structures around them. …”
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    Senescent tumor cells building three-dimensional tumor clusters
  3. 1043
    “…Cellular senescence is a complex cell fate response that is thought to underlie several age-related pathologies. …”
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    Mitochondrial peptides modulate mitochondrial function during cellular senescence
  4. 1044
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    Involvement of REL/NF-B Transcription Factors in Cellular Senescence
  5. 1045
    “…The post-mitotic phase of senescence is dynamic, making the detection of senescent cells in vivo difficult. …”
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    The induction of the fibroblast extracellular senescence metabolome is a dynamic process
  6. 1046
    “…Senescent cells accumulate in multiple aging‐associated diseases, and eliminating these cells has recently emerged as a promising therapeutic approach. …”
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    A versatile drug delivery system targeting senescent cells
  7. 1047
    “…In this review, we discuss the pro- and anti-tumorigenesis functions of senescence and summarize the key roles of kinase modulators in the regulation of senescence against tumors.…”
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    The Role of Kinase Modulators in Cellular Senescence for Use in Cancer Treatment
  8. 1048
    “…Genome amplification and cellular senescence are commonly associated with pathological processes. …”
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    Genome amplification and cellular senescence are hallmarks of human placenta development
  9. 1049
    “…Increasing evidence highlights that senescence plays an important role in idiopathic pulmonary fibrosis (IPF). …”
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    Mitochondrial dysfunction contributes to the senescent phenotype of IPF lung fibroblasts
  10. 1050
    “…Since the effective concentration inducing cell senescence in hepatocarcinoma cells is clinically available, whether a clinical dose of SVP could induce cell senescence in clinical hepatocarcinoma is worthy of further study.…”
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    Sodium Valproate Induces Cell Senescence in Human Hepatocarcinoma Cells
  11. 1051
    “…The extension of DNA damage and cellular senescence have been assessed by immunofluorescence, western-blot and senescence-associated β-galactosidase activity. …”
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    Detrimental pro-senescence effects of vitamin D on lung fibrosis
  12. 1052
    “…Cellular senescence is a stress response that imposes stable cell-cycle arrest in damaged cells, preventing their propagation in tissues. …”
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    Impaired immune surveillance accelerates accumulation of senescent cells and aging
  13. 1053
    “…Recently, we identified a minor memory-phenotype CD4(+) T cell subpopulation that constitutively expressed PD-1 and CD153 as a bona fide age-dependent T cell population; we termed these cells senescence-associated T (SA-T) cells. SA-T cells exhibit characteristic features of cellular senescence, with defective T cell receptor-mediated proliferation and T cell cytokine production. …”
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    The impact of senescence-associated T cells on immunosenescence and age-related disorders
  14. 1054
    por Uni, Masahiro, Kurokawa, Mineo
    Publicado 2018
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    Role of ASXL1 mutation in impaired hematopoiesis and cellular senescence
  15. 1055
    “…Senescence is a result of cellular stress and is a potential mechanism for regulating cancer. …”
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    Mechanisms shaping the role of ERK1/2 in cellular senescence
  16. 1056
    “…We examined the effect of progesterone treatments on glycolytic metabolism and senescence as possible mechanisms in controlling the growth of glioblastoma multiforme (GBM). …”
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    Progesterone Treatment Attenuates Glycolytic Metabolism and Induces Senescence in Glioblastoma
  17. 1057
    “…In addition to regulating the cell replicative senescence, telomere biology plays a fundamental role in regulating the chronological post-mitotic cell ageing. …”
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    Roles of Telomere Biology in Cell Senescence, Replicative and Chronological Ageing
  18. 1058
    “…During oncogene-induced senescence (OIS), heterochromatin is lost from the nuclear periphery and forms internal senescence-associated heterochromatin foci (SAHFs). …”
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    Nuclear pore density controls heterochromatin reorganization during senescence
  19. 1059
    “…Based on the observation that senescent cells are large and exhibit many of the phenotypes of large cells, we propose that the range of DNA:cytoplasm ratio that supports optimal cell function is limited and that ratios outside these bounds contribute to aging.…”
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    Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence
  20. 1060
    “…BACKGROUND: Senescence has been recognized as a mechanism for the suppression of tumorigenesis. …”
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    MLL3 promotes the senescence of esophageal squamous cell carcinoma
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