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  1. 1061
    “…Most cancers arise in old individuals, which also accumulate senescent cells. Cellular senescence can be experimentally induced by expression of oncogenes or telomere shortening during serial passage in culture. …”
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    Circumventing senescence is associated with stem cell properties and metformin sensitivity
  2. 1062
    “…Removing extranuclear DNA in old cells using DNASE2A reduced innate immune responses and senescence‐associated (SA) β‐gal enzyme activity. Cells and tissues of Dnase2a(−) (/) (−) mice with defective DNA degradation exhibited slower growth, higher activity of β‐gal, or increased expression of HP‐1β and p16 proteins, while Dnase2a(−) (/) (−);Sting(−) (/) (−) cells and tissues were rescued from these phenotypes, supporting a role for extranuclear DNA in senescence. …”
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    Extranuclear DNA accumulates in aged cells and contributes to senescence and inflammation
  3. 1063
    “…However, the functional characteristics of T-cell senescence in the abnormal glucose homeostasis are not fully understood. …”
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    T-cell senescence contributes to abnormal glucose homeostasis in humans and mice
  4. 1064
    “…The maintenance of mitochondrial function is closely linked to the control of senescence. In our previous study, we uncovered a novel mechanism in which senescence amelioration in normal aging cells is mediated by the recovered mitochondrial function upon Ataxia telangiectasia mutated (ATM) inhibition. …”
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    Alleviation of Senescence via ATM Inhibition in Accelerated Aging Models
  5. 1065
    por ÖKTEM, Mert, KELEŞ, Yüksel
    Publicado 2018
    “…The control of senescence has economic importance due to its effects on parameters such as herbal product quality and shelf life. …”
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    The role of silver ions in the regulation of the senescence process in Triticum aestivum
  6. 1066
    “…Cellular senescence is a driver of various aging-associated disorders, including osteoarthritis. …”
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    Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis
  7. 1067
    “…Therefore, in De Hui City, Jilin Province, southwestern 20° ‘160 + 40’ delayed leaf senescence at the late stage of growth of maize, as well as the effect of increasing maize yield was most obvious.…”
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    Effects of row direction and row spacing on maize leaf senescence
  8. 1068
    “…This study aimed to investigate the role of senescence of bone marrow (BM)-derived cells in the development of AKI, focusing on the immune response. …”
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    The role of senescence of bone marrow cells in acute kidney injury
  9. 1069
    “…We observed that responses to these chromatin changes may be distinct in individual cell types, suggesting that expression of lamin A/C and lamin B1 (LB1) may play an important role in the transition of damaged cells to senescence. MCF7 mammary carcinoma cells harboring wild‐type p53 (WT‐p53) and LA/C responded to RS by transition to senescence with a significant reduction of lamin B receptor and LB1 proteins. …”
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    Distinct cellular responses to replication stress leading to apoptosis or senescence
  10. 1070
    “…Here, we show that NOR additionally controls leaf senescence. Expression of NOR increases with leaf age, and developmental as well as dark-induced senescence are delayed in the nor mutant, while overexpression of NOR promotes leaf senescence. …”
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    Tomato fruit ripening factor NOR controls leaf senescence
  11. 1071
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    Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis
  12. 1072
    “…Furthermore, senescent glial cells exhibit excessive fat deposits, a phenotype we termed “accumulation of lipids in senescence.” …”
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    Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis
  13. 1073
    “…Here, we show that reducing senescent cell burden in obese mice, either by activating drug‐inducible “suicide” genes driven by the p16(Ink4a) promoter or by treatment with senolytic agents, alleviates metabolic and adipose tissue dysfunction. …”
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    Targeting senescent cells alleviates obesity‐induced metabolic dysfunction
  14. 1074
    “…The IFN-I response is a novel phenotype of late senescence and contributes to the maintenance of the senescence associated secretory phenotype (SASP). …”
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    LINE-1 derepression in senescent cells triggers interferon and inflammaging
  15. 1075
    “…Apoptosis and senescence are two mutually exclusive cell fate programs that can be activated by stress. …”
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    Autophagy-induced senescence is regulated by p38α signaling
  16. 1076
    “…A widely appreciated conclusion from evolutionary theory is that senescence (aging) is of no adaptive value to the individual that it afflicts. …”
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    Does senescence promote fitness in Caenorhabditis elegans by causing death?
  17. 1077
    por Wang, Haojie, Schippers, Jos H. M.
    Publicado 2019
    “…Aging and senescence in plants has a major impact on agriculture, such as in crop yield, the value of ornamental crops, and the shelf life of vegetables and fruits. …”
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    The Role and Regulation of Autophagy and the Proteasome During Aging and Senescence in Plants
  18. 1078
    por Li, Yanjun, Liu, Lei, Zhu, Yushan, Chen, Quan
    Publicado 2019
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    Mitochondria organize the cellular proteostatic response and promote cellular senescence
  19. 1079
    “…Leaf senescence is characterized by massive degradation of chloroplast proteins, yet the protease(s) involved is(are) not completely known. …”
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    Chloroplast Protein Degradation in Senescing Leaves: Proteases and Lytic Compartments
  20. 1080
    “…Here, we aimed to examine in depth the impact of immunological and biological senescence and immune activation on disease outcome in elderly patients with colorectal cancer (CRC).Peripheral blood samples from 81 CRC patients were studied for immune activation, immune senescence and recent thymic emigrant(RTE) CD4 and CD8 cells by flow cytometry. …”
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    Immune senescence and immune activation in elderly colorectal cancer patients
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