“…Chromatin organization and transcriptional profiles undergo tremendous reordering during senescence. However, uncovering the regulatory mechanisms between chromatin reconstruction and gene expression in senescence has been elusive. …”
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“…This way, the plant would assure that two coordinated aspects of development such as flowering and organ senescence were sequentially controlled. As in the case of senescence, there is growing evidence to support the idea that harnessing the reliability of photoperiod regulation over other, more labile signaling pathways could be used as a robust breeding tool to enhance plants against the harmful effects of climate change.…”
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“…Senescence is especially relevant to late-stage brain cancer since it occurs mainly in aged people, who have senescent cells. …”
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“…Since senescence of cells in the bone microenvironment has been reported as a cause of age-induced bone loss, we hypothesized that PPR signaling protects osteocytes from senescence. …”
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“…In this study, we report that ionizing radiation (IR) increase cellular senescence with higher expression of senescence-associated β-galactosidase (SA-β-Gal) and senescence-specific genes (p16, p21, Bcl-2, and Bcl-xl) in irradiated bone marrow-derived monocytes/macrophages (BMMs). …”
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“…OBJECTIVES: Senescence, characterized by permanent cycle arrest, plays an important role in diabetic nephropathy (DN). …”
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“…Increasing evidence suggests that inducing T cell senescence is a key strategy used by malignant tumours to evade immune surveillance. …”
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“…Transcriptomic and biochemical analysis revealed that DMF rescue was underpinned by reduced Nf-kB and TGF-β signaling and cell senescence. Following on from these studies, we employed a Zebrafish model to study paracetamol exposure in vivo. …”
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“…These mutations lead to the generation of sub-optimal proteins, resulting in inadequate cellular homeostasis and senescence. The build-up of senescent cells negatively affects the local cellular micro-environment and drives ageing associated disease, including neurodegeneration. …”
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“…Although evidence suggests that aging may drive Redd1 expression in skeletal muscles, the expression patterns and functions of Redd1 in senescent cardiomyocytes remain unspecified. To address this issue, in vitro and in vivo models of cardiomyocyte senescence were established by administration of doxorubicin (Dox). …”
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“…INTRODUCTION: Senescent cells have been demonstrated to release High Mobility Group Box 1 (HMGB1) which induces labor through an inflammatory pathway. …”
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“…We argue that these four key aspects can help us understand why patterns of negligible and negative senescence can actually be explained under the same evolutionary framework as classical senescence.…”
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“…We analyzed the effects of TERT overexpression or deficiency on expression of CDKN2A and ACTA2 as indicators of senescence and differentiation, respectively. We assess binding of TERT or YB-1, a repressor of both genes, to their promoters. …”
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“…The non-invasive real-time senescence tracking provided by QM-NHαfuc was validated in an in vivo senescence model. …”
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“…In recent years, this significant gap has been identified and work has begun to investigate the various ways immunometabolism could be impacted by both chronological age and age-associated symptoms, such as the systemic accumulation of senescent cells. Here, in this mini-review, we will examine immunometabolism with a focus on T cells, aging, and interventions, such as mTOR modulators and senolytics. …”
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“…The impaired effector function of exhausted and senescent T cells is implicated in cancer progression and inadequate vaccine responses. …”
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“…DFO thus accelerates EPC senescence and appears to hasten model development for cellular senescence studies.…”
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“…Intervention experiments have proven cell senescence as a relevant cause of ageing in many organs. …”
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