“…Two of the hallmarks of aging include inflammation and cellular senescence, which have been attributed as drivers of age-related organ decline. …”
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“…Senescence is a double-edged sword in tumorigenesis and affects the immunotherapy response through the modulation of the host’s immune system. …”
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“…Senescent cells (SnCs) can develop a characteristic pathogenic senescence-associated secretory phenotype (SASP) that drives secondary senescence and disrupts tissue homeostasis, resulting in loss of tissue repair and regeneration. …”
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“…We found that 40 miRNAs were upregulated and 70 miRNAs were downregulated during chondrocyte senescence, and that miR-132-5p expression inhibition prevented chondrocyte senescence. …”
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“…Background: Cellular senescence plays a critical role in the occurrence and development, and immune modulation of cancer. …”
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“…Numerous molecules and pathways, including sirtuins, Klotho, RAAS, IGFBP, NRF2, and mTOR, have been implicated in promoting EC senescence. This review summarizes the molecular players and signaling pathways driving EC senescence and identifies targets with possible therapeutic value in age-related vascular diseases.…”
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“…The purpose of this paper is to analyze the pathogenesis of AAA from the perspective of cellular senescence: on the basis of clear evidence of cellular senescence in aneurysm wall, we actively elucidate specific molecular and regulatory pathways, and to explore the targeted drugs related to senescence and senescent cells eliminate measures, eventually improve the health of patients with AAA and prolong the life of human beings.…”
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“…However, its role in cellular senescence remains undefined. We investigated the potential mechanism for PCAF-mediated cellular senescence. …”
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“…Horticultural products display fast senescence after harvest at ambient temperatures, resulting in decreased quality and shorter shelf life. …”
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“…Cellular senescence process results in stable cell cycle arrest, which prevents cell proliferation. …”
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“…Recent evidence suggests that an increased burden of senescent cells (SCs) in the adipose tissue of obese/diabetic animal models might underlie such pro-inflammatory phenotype. …”
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“…Cellular senescence is a complex multifactorial biological phenomenon that plays essential roles in aging, and aging-related diseases. …”
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“…Together, these data demonstrate the prevalence of senescence in respiratory viral infection and suggest F3 as a critical link between inflammation, thrombosis, and senescence in these disease states.…”
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“…Serial passage studies in vitro confirmed the accelerated increase in senescence and the acquisition of a senescence-associated secretory phenotype in DM1 fibroblasts, whereas the DM1 Drosophila model showed reduced longevity and impaired locomotor activity. …”
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“…In this review, we focus on the senescence of alveolar type II epithelial cells (AECIIs) and systematically summarize abnormal changes in signal pathways and biological process and implications of senescent AECIIs during IPF progression. …”
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“…Accumulation of senescent dermal fibroblasts drives skin aging. The reactivation of proliferation is one strategy to modulate cell senescence. …”
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“…According to studies, senescence is a primary anti-tumor mechanism that may be seen in a variety of tumor types. …”
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“…Senescence is a programmed process that involves the destruction of the photosynthesis apparatus and the relocation of nutrients to the grain. …”
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“…Here, we report that impaired mitochondrial function is associated with increased glutamine catabolism in senescent human mesenchymal stem cells (MSCs) and myofibroblasts derived from patients suffering from Hutchinson-Gilford progeria syndrome. …”
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“…Results: By detecting the relative expression of each pathway and the correlation between genes or pathways, we found that COVID-19 could induce testicular cell senescence through MAPK signaling pathway. Cellular senescence was synergistic with MAPK pathway, which further affected the normal synthesis of cholesterol and androgen, inhibited the normal synthesis of lactate and pyruvate, and ultimately affected spermatogenesis. …”
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