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  1. 1221
    “…Historically, senescence has been considered a safe program in response to multiple stresses in which cells undergo irreversible growth arrest. …”
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    IL-1 and senescence: Friends and foe of EGFR neutralization and immunotherapy
  2. 1222
    “…Senescence is a cellular response characterized by cells irreversibly stopping dividing and entering a state of permanent growth arrest. …”
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    Ultra-small polydopamine nanomedicine-enabled antioxidation against senescence
  3. 1223
    Publicado 2022
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    Correction to: Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy
  4. 1224
    Publicado 2023
    “…Given its state of stable proliferative inhibition, cellular senescence is primarily depicted as a critical mechanism by which organisms delay the progression of carcinogenesis. …”
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    Multiple characteristic alterations and available therapeutic strategies of cellular senescence
  5. 1225
    “…Aging is a complex process characterized by an ongoing decline in physiological functions, leading to degenerative diseases and an increased probability of death. Cellular senescence has been typically considered as an anti-proliferative process; however, the chronic accumulation of senescent cells contributes to tissue dysfunction and aging. …”
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    Hallmarks and Biomarkers of Skin Senescence: An Updated Review of Skin Senotherapeutics
  6. 1226
    “…Cytokinins (CKs) are a class of adenine-derived plant hormones that plays pervasive roles in plant growth and development including cell division, morphogenesis, lateral bud outgrowth, leaf expansion and senescence. CKs as a “fountain of youth” prolongs leaf longevity by inhibiting leaf senescence, and therefore must be catabolized for senescence to occur. …”
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    The leaf senescence-promoting transcription factor AtNAP activates its direct target gene CYTOKININ OXIDASE 3 to facilitate senescence processes by degrading cytokinins
  7. 1227
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    Senescence-associated lysosomal α-L-fucosidase (SA-α-Fuc): A sensitive and more robust biomarker for cellular senescence beyond SA-β-Gal
  8. 1228
    “…In order to provide a sufficient number of cells for clinical use, mesenchymal stem cells (MSCs) must be cultured for long-term expansion, which inevitably triggers cellular senescence. Although the small size of MSCs is known as a critical determinant of their fate, the main regulators of stem cell senescence and the underlying signaling have not been addressed. …”
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    Senescence-Associated Secretory Phenotype Suppression Mediated by Small-Sized Mesenchymal Stem Cells Delays Cellular Senescence through TLR2 and TLR5 Signaling
  9. 1229
    “…Moreover, expression of senescence-associated beta-galactosidase was induced and levels of the senescence-associated secretory phenotype (SASP) proteins TGFβ1, CTGF (CCN2), and LGLAS3 were increased as well as the transcript levels of additional genes encoding SASP proteins in the Pdgfra-Cre:Lmna(F/F) mouse hearts. …”
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    Deletion of the Lmna gene in fibroblasts causes senescence-associated dilated cardiomyopathy by activating the double-stranded DNA damage response and induction of senescence-associated secretory phenotype
  10. 1230
    “…Premature senescence of leaves causes a reduced yield and quality of rice by affecting plant growth and development. …”
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    Mutation of Leaf Senescence 1 Encoding a C2H2 Zinc Finger Protein Induces ROS Accumulation and Accelerates Leaf Senescence in Rice
  11. 1231
    “…Here we used human dermal fibroblasts (HDFs) treated with doxorubicin (doxo) to induce senescence. The senescent phenotype of these stress-induced premature senescent (SIPS) cells was confirmed with several markers. …”
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    The expression of fibrosis-related genes is elevated in doxorubicin-induced senescent human dermal fibroblasts, but their secretome does not trigger a paracrine fibrotic response in non-senescent cells
  12. 1232
    “…Objective: We propose here material-induced senescence (MIS) as a new therapeutic concept that limits cancer progression by stable cell cycle arrest. …”
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    Material-induced Senescence (MIS): Fluidity Induces Senescent Type Cell Death of Lung Cancer Cells via Insulin-Like Growth Factor Binding Protein 5
  13. 1233
    “…Importantly, loss-of-function of REF6 increased H3K27me3 levels at all the target Senescence associated genes (SAGs). We therefore conclusively demonstrate that H3K27me3 methylation represents an epigenetic mechanism prohibiting the premature transcriptional activation of key developmentally up-regulated senescence regulatory as well as functional genes in Arabidopsis.…”
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    The H3K27me3 demethylase REF6 promotes leaf senescence through directly activating major senescence regulatory and functional genes in Arabidopsis
  14. 1234
    “…RESULTS: We found that CSM increased AECII senescence, while SAL-RNA1 overexpression and SIRT1 activation significantly decreased levels of AECII senescence induced by CSM. …”
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    Senescence associated long non-coding RNA 1 regulates cigarette smoke-induced senescence of type II alveolar epithelial cells through sirtuin-1 signaling
  15. 1235
    por Blagosklonny, Mikhail V.
    Publicado 2023
    “…At the very moment of cell-cycle arrest, the cell is not senescent yet. For several days in cell culture, the arrested cell is acquiring a senescent phenotype. …”
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    Cellular senescence: when growth stimulation meets cell cycle arrest
  16. 1236
    “…Re-expression of Parkin in RhoA-depleted cardiomyocytes restored mitophagy, reduced mitochondrial damage, attenuated cardiomyocyte senescence, and rescued cardiac function both in vitro and in vivo. …”
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    RhoA rescues cardiac senescence by regulating Parkin-mediated mitophagy
  17. 1237
    “…Combined with relevant studies, we review the dual role of cell senescence in GI cancer, including the mechanism of inducing cell senescence, biomarkers of senescent cells, and potential of targeted senescence therapy for GI cancer.…”
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    A strategy for the treatment of gastrointestinal cancer: Targeting tumor senescent cells
  18. 1238
    “…We identified distinct senescence-related molecular subtypes and critical genes among prostate cancer (PCa) patients undergoing radical prostatectomy (RP) or radical radiotherapy (RT). …”
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    Identification of senescence-related molecular subtypes and key genes for prostate cancer
  19. 1239
    “…These new data also shed light on the mechanisms that sensitize senescent cells to CD8 T cell-dependent killing, as well as those that enable senescent cells to evade CD8 T cell immunosurveillance. …”
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    Recent insights into the crosstalk between senescent cells and CD8 T lymphocytes
  20. 1240
    por San-Millán, Marta, Rissech, Carme
    Publicado 2023
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    Inter-population differences in acetabular senescence: relevance in age-at-death estimation
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