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  1. 1261
    “…Animal models (e.g., rodents) have been used to understand age-related changes in brain function—particularly through the senescence-accelerated mouse (SAM) strain. Previous reports have shown that the senescence-accelerated mouse propensity (SAMP)8 and SAMP10 strains have learning disabilities. …”
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    Component-specific reduction in perineuronal nets in senescence-accelerated mouse strains
  2. 1262
    “…Hepatic metastasis is a clinical challenge for colorectal cancer (CRC). Senescent cancer cells accumulate in CRC favoring tumor dissemination. …”
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    Spatial resolution of cellular senescence dynamics in human colorectal liver metastasis
  3. 1263
    “…Senescence starts at different times in European aspen (Populus tremula L.) genotypes grown in same location. …”
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    Salicylic acid metabolism and signalling coordinate senescence initiation in aspen in nature
  4. 1264
    “…Metabolic modulation and anti-senescence therapy are gaining the attention of researchers as emerging immunotherapeutic strategies for tumors. …”
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    Metabolism and senescence in the immune microenvironment of osteosarcoma: focus on new therapeutic strategies
  5. 1265
    “…Mitochondrial dysfunction is a hallmark feature of cellular senescence and organ aging. Here, we asked whether the mitochondrial antiviral signaling protein (MAVS), which is essential for driving antiviral response, also regulates human stem cell senescence. …”
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    MAVS Antagonizes Human Stem Cell Senescence as a Mitochondrial Stabilizer
  6. 1266
    “…Senescence, a state of irreversible cell-cycle withdrawal, is difficult to distinguish from quiescence, a state of reversible cell-cycle withdrawal. …”
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    The intensities of canonical senescence biomarkers integrate the duration of cell-cycle withdrawal
  7. 1267
    “…We find that many of those cells acquire persistent activity of the JNK pathway, which drives them into senescent status, characterized by arrest of cell division, cell hypertrophy, Senescent Associated ß-gal activity (SA-ß-gal), reactive oxygen species (ROS) production, Senescent Associated Secretory Phenotype (SASP) and migratory behaviour. …”
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    Lack of apoptosis leads to cellular senescence and tumorigenesis in Drosophila epithelial cells
  8. 1268
    “…Erythropoietin (EPO) suppresses drug-induced apoptosis in EPO-receptor-positive leukemia cells and allows cells to persist after drug treatment by promoting cellular senescence. Importantly a small proportion of senescent cells can re-enter the cell cycle and resume proliferation after drug treatment, resulting in disease recurrence/persistence. …”
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    Heterogeneity in leukemia cells that escape drug-induced senescence-like state
  9. 1269
    “…Rationale: Senescent melanocytes accumulate in photoaged skin and are closely related to skin aging. …”
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    Senescent melanocytes driven by glycolytic changes are characterized by melanosome transport dysfunction
  10. 1270
    “…Cellular senescence seems to induce sortilin expression.…”
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    Sortilin Is Upregulated in Osteoarthritis-Dependent Cartilage Calcification and Associated with Cellular Senescence
  11. 1271
    “…Cellular senescence is a durable cell cycle arrest as a result of the finite proliferative capacity of cells. …”
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    Mass Cytometry as a Tool for Investigating Senescence in Multiple Model Systems
  12. 1272
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    LSD 4.0: an improved database for comparative studies of leaf senescence
  13. 1273
    “…This pitfall may be due to the lack of understanding of the mechanisms underlying chondrocyte senescence. Therefore, our study aimed to generate models of chondrocyte senescence. …”
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    Development of a DNA damage-induced senescence model in osteoarthritic chondrocytes
  14. 1274
    “…Telomeres play pivotal roles in processes closely related to somatic senescence and aging, making them a compelling target for interventions aimed at combating aging and age-related pathologies. …”
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    Ginsenoside F1-Mediated Telomere Preservation Delays Cellular Senescence
  15. 1275
    “…However, the precise mechanisms linking premature senescence to CVD in cancer survivors remain poorly understood. …”
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    Premature senescence and cardiovascular disease following cancer treatments: mechanistic insights
  16. 1276
    “…In the first model, replicative, senescent, extended lifespan, immortal and tumor cells are considered, while the second also includes immune cells. …”
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    Fitting parameters and therapies of ODE tumor models with senescence and immune system
  17. 1277
    “…Methods: We examined cell morphology, senescence-associated β-galactosidase (SA-β-gal) activity, cell proliferation, and expression of senescence markers (p16 and p21). …”
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    Gene expression signatures of human senescent corneal and conjunctival epithelial cells
  18. 1278
    “…KLF14 deficiency facilitates cellular senescence and aging‐related pathologies in C57BL/6J mice, whereas KLF14 overexpression attenuates cellular senescence. …”
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    Downregulation of Krüppel‐like factor 14 accelerated cellular senescence and aging
  19. 1279
    por Rogers, Hilary J.
    Publicado 2023
    “…Floral senescence is of fundamental interest in understanding plant developmental regulation, it is of ecological and agricultural interest in relation to seed production, and is of key importance to the production of cut flowers. …”
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    How far can omics go in unveiling the mechanisms of floral senescence?
  20. 1280
    “…Adipose-derived stem cells from the stromal vascular fraction derived from WS subcutaneous adipose tissues (WSVF) showed early replicative senescence and a significant increase in the expression of senescence-associated secretory phenotype (SASP) markers. …”
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    Senescence-associated inflammation and inhibition of adipogenesis in subcutaneous fat in Werner syndrome
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