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  1. 1321
    “…Here, we performed an in-depth examination of mitochondrial function in saponin-permeabilized cardiomyocyte bundles, a preparation where all mitochondria are represented and their structure intact, from young adult (YA) and senescent (SEN) rats (n = 8 per group). When accounting for increased fibrosis (+19%, P<0.01) and proportional decrease in citrate synthase activity in the SEN myocardium (−23%, P<0.05), mitochondrial respiration and reactive oxygen species (H(2)O(2)) emission across a range of energized states was similar between age groups. …”
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    Mitochondrial Function in Permeabilized Cardiomyocytes Is Largely Preserved in the Senescent Rat Myocardium
  2. 1322
    “…BACKGROUND: Cellular senescence is a stress response of mammalian cells leading to a durable arrest of cell proliferation that has been implicated in tumor suppression, wound healing, and aging. …”
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    Deacetylation of H4-K16Ac and heterochromatin assembly in senescence
  3. 1323
    “…Previous studies have documented various types of sperm senescence, but evidence of post-meiotic intra-testicular sperm senescence in wild animals is lacking. …”
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    Post-Meiotic Intra-Testicular Sperm Senescence in a Wild Vertebrate
  4. 1324
    “…Cellular senescence both protects multicellular organisms from cancer and contributes to their aging(1). …”
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    Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence
  5. 1325
    “…Senescent cells are relatively stable, lacking proliferation capacity yet retaining metabolic activity. …”
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    The Yin-Yang of DNA Damage Response: Roles in Tumorigenesis and Cellular Senescence
  6. 1326
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    A new path to oncogene-induced senescence: At the crossroads of splicing and translation
  7. 1327
    “…Our observations suggest that CSE exposure impairs fibroblast growth and proliferation and leads to features similar to those seen in senescent cells. Oxidative stress injury and inhibition of antioxidant defense activity may be involved in CSE-induced fibroblast senescence.…”
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    Effects of Cigarette Smoke Extracts on the Growth and Senescence of Skin Fibroblasts In Vitro
  8. 1328
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    Accelerated Bone Mass Senescence After Hematopoietic Stem Cell Transplantation
  9. 1329
    “…Oncogene-induced senescence (OIS) is crucial for tumour suppression. …”
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    A complex secretory program orchestrated by the inflammasome controls paracrine senescence
  10. 1330
    “…These functional defects were associated with morphological changes, increase in senescence-associated-β-galactosidase activity, upregulation of cell cycle inhibitors and accumulation of c-Myc-deficient cells in G1-phase, indicating that c-Myc knockdown in endothelial cells induces senescence. …”
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    c-Myc Is Essential to Prevent Endothelial Pro-Inflammatory Senescent Phenotype
  11. 1331
    “…Here we showed that senescent cardiac fibroblasts markedly accumulated in heart after myocardial infarction. …”
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    Senescent Cardiac Fibroblast Is Critical for Cardiac Fibrosis after Myocardial Infarction
  12. 1332
    “…In this study, we demonstrate that treatment of tomato plants with geraniol results in induction of senescence due to a substantial alteration in transcriptome. …”
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    Induction of Senescence and Identification of Differentially Expressed Genes in Tomato in Response to Monoterpene
  13. 1333
    “…We currently tested whether Berberine can affect premature, stress-induced cellular senescence caused by mitoxantrone. The depth of senescence was quantitatively measured by morphometric parameters, senescence-associated β-galactosidase, induction of p21(WAF1), replication stress (γH2AX expression), and mTOR signaling; the latter revealed by ribosomal S6 protein (rpS6) phosphorylation. …”
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    Berberine suppresses gero-conversion from cell cycle arrest to senescence
  14. 1334
    “…The relationships between senescence and immune infiltrates have not previously been studied in humans. …”
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    The in situ local immune response, tumour senescence and proliferation in colorectal cancer
  15. 1335
    “…Senescence-Associated β-galactosidase (SA-β-Gal) staining, and BrdU assays were used to detect cellular senescence. …”
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    Central Role of Cellular Senescence in TSLP-Induced Airway Remodeling in Asthma
  16. 1336
    “…In the current work we have explored the effect of NTN4/ITGB4 interaction on TMZ induced glioblastoma cell senescence. We report here that the suppression of either ITGB4 or NTN4 in glioblastoma cell lines significantly enhances cellular senescence. …”
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    NETRIN-4 Protects Glioblastoma Cells FROM Temozolomide Induced Senescence
  17. 1337
    por Lutz, Hans U., Bogdanova, Anna
    Publicado 2013
    “…This review focuses on the analysis and evaluation of the diverse senescence markers suggested to prime red blood cells (RBC) for clearance in humans. …”
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    Mechanisms tagging senescent red blood cells for clearance in healthy humans
  18. 1338
    “…In this paper, we demonstrate that binding of TH T3 (triiodothyronine) to THRB induces senescence and deoxyribonucleic acid (DNA) damage in cultured cells and in tissues of young hyperthyroid mice. …”
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    The thyroid hormone receptor β induces DNA damage and premature senescence
  19. 1339
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    miR-141, a new player, joins the senescence orchestra
  20. 1340
    “…Cellular senescence has evolved from an in-vitro model system to study aging in vitro to a multifaceted phenomenon of in-vivo importance as senescent cells in vivo have been identified and their removal delays the onset of age-associated diseases in a mouse model system. …”
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    From cellular senescence to age-associated diseases: the miRNA connection
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