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  1. 1381
    “…Within the last decade, NAC transcription factors have been shown to play essential roles in senescence, which is the focus of this review. Transcriptome analyses associate approximately one third of Arabidopsis NAC genes and many crop NAC genes with senescence, thereby implicating NAC genes as important regulators of the senescence process. …”
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    NAC Transcription Factors in Senescence: From Molecular Structure to Function in Crops
  2. 1382
    “…Inhibiting the Sirt1 pathway accelerated cartilage senescence in knockout (KO) mice. Activating the leptin pathway induced higher Ob-Rb expression and was significantly correlated with cartilage degeneration (lower levels of Coll-2) and tissue senescence (higher levels of p53/p21 and lower levels of Sirt1) in OA patients, suggesting that leptin-induced CPCs senescence contributes to the development of OA. …”
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    Leptin changes differentiation fate and induces senescence in chondrogenic progenitor cells
  3. 1383
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    The Influence of Na(+), K(+)-ATPase on Glutamate Signaling in Neurodegenerative Diseases and Senescence
  4. 1384
    “…In contrast, under experimentally induced senescence, SAQR expression increases in vasculature of cotyledons but not in true leaves. …”
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    A Clade-Specific Arabidopsis Gene Connects Primary Metabolism and Senescence
  5. 1385
    “…The accumulation of senescent disc cells in degenerative intervertebral disc (IVD) suggests the detrimental roles of cell senescence in the pathogenesis of intervertebral disc degeneration (IDD). …”
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    Disc cell senescence in intervertebral disc degeneration: Causes and molecular pathways
  6. 1386
    “…Its juice is extracted for sugar production, while sugarcane bagasse, straw, and senescing leaves are considered industrial waste. Senescence is the age-dependent deterioration of plant cells, ultimately leading to cell death and completion of the plant life cycle. …”
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    Characterization of sugarcane (Saccharum spp.) leaf senescence: implications for biofuel production
  7. 1387
    “…The tRNA methyltransferase NSUN2 delays replicative senescence by regulating the translation of CDK1 and CDKN1B mRNAs. …”
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    RNA methyltransferase NSUN2 promotes stress-induced HUVEC senescence
  8. 1388
    “…Here, we investigated the mechanism of H(2)S in alleviating postharvest senescence and rotting of Kyoho grape. Exogenous application of H(2)S released from 1.0 mM NaHS remarkably decreased the rotting and threshing rate of grape berries. …”
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    Hydrogen Sulfide Alleviates Postharvest Senescence of Grape by Modulating the Antioxidant Defenses
  9. 1389
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    Diminished KCC2 confounds synapse-specificity of LTP during senescence
  10. 1390
    “…A key feature of aging biology that may underlie these diseases is cellular senescence. Senescent cells accumulate in tissues with age, undergo widespread changes in gene expression, and typically demonstrate altered, pro-inflammatory profiles. …”
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    Changes in the Transcriptome of Human Astrocytes Accompanying Oxidative Stress-Induced Senescence
  11. 1391
    “…The GR2 RNAi plants displayed early onset of age‐dependent and dark‐ and H(2)O(2)‐induced leaf senescence, which was accompanied by the induction of the senescence‐related marker genes SAG12 and SAG13. …”
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    Decreased glutathione reductase2 leads to early leaf senescence in Arabidopsis
  12. 1392
    “…In vivo evidence for increased senescence in Gadd45b null mice includes the observation that embryos from Gadd45b null mice exhibit increased senescence staining compared to wild type embryos. …”
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    Gadd45b deficiency promotes premature senescence and skin aging
  13. 1393
    por Flor, Amy C, Kron, Stephen J
    Publicado 2016
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    Lipid-derived reactive aldehydes link oxidative stress to cell senescence
  14. 1394
    “…RESULTS: We observed enhanced T cell exhaustion and senescence especially at the tumor site. CD8+ T cells expressed several molecules associated with T cell exhaustion (PD-1, CTLA-4, 2B4, CD160) and T cell senescence (CD57, lack of CD28). …”
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    T cells in multiple myeloma display features of exhaustion and senescence at the tumor site
  15. 1395
    “…Cellular senescence contributes to organismal development, aging, and diverse pathologies, yet available assays to detect senescent cells remain unsatisfactory. …”
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    Robust, universal biomarker assay to detect senescent cells in biological specimens
  16. 1396
    “…The growth of tumors in a mouse peritoneal cavity was intensified when the cancer cells were co-injected together with senescent HPMCs. This effect was reversible when the senescence of HPMCs was slowed down by the neutralization of p38 MAPK. …”
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    Senescent peritoneal mesothelium creates a niche for ovarian cancer metastases
  17. 1397
    “…Here, we show that cell senescence is an intrinsic part of the developmental programme in amphibians. …”
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    Conserved and novel functions of programmed cellular senescence during vertebrate development
  18. 1398
    “…Enlarged cells are one of the hallmarks of senescence, but whether RS cells are senescent has not been previously investigated. …”
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    Reed-Sternberg cells in Hodgkin's lymphoma present features of cellular senescence
  19. 1399
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    Common Delayed Senescence of Melanocytes from Multiple Primary Melanoma Patients
  20. 1400
    “…Senescence is a form of cell cycle arrest induced by stress such as DNA damage and oncogenes. …”
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    The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration
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