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1421por Chen, Meng, Lyu, Guoliang, Han, Miao, Nie, Hongbo, Shen, Ting, Chen, Wei, Niu, Yichi, Song, Yifan, Li, Xueping, Li, Huan, Chen, Xinyu, Wang, Ziyue, Xia, Zheng, Li, Wei, Tian, Xiao-Li, Ding, Chen, Gu, Jun, Zheng, Yufang, Liu, Xinhua, Hu, Jinfeng, Wei, Gang, Tao, Wei, Ni, Ting“…Cellular senescence has been viewed as a tumor suppression mechanism and also as a contributor to individual aging. …”
Publicado 2018
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1422“…Our functional experiments in cancer cell lines show that heterochromatin in cancer cells is tethered to the INM by LBR, which is downregulated together with lamin B1 at the onset of cell transition to senescence. The downregulation of these proteins in senescent cells leads to the detachment of centromeric repetitive sequences from INM, their relocation to the nucleoplasm, and distension. …”
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1423por Wang, Hong, Chang, XiaoXiao, Lin, Jing, Chang, Youhong, Chen, Jen-Chih, Reid, Michael S., Jiang, Cai-Zhong“…The genetic regulatory mechanisms that govern natural corolla senescence in petunia are not well understood. To identify key genes and pathways that regulate the process, we performed a transcriptome analysis in petunia corolla at four developmental stages, including corolla fully opening without anther dehiscence (D0), corolla expansion, 2 days after anthesis (D2), corolla with initial signs of senescence (D4), and wilting corolla (D7). …”
Publicado 2018
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1424por Ohmura, Hiroshi, Tahara, Hidetoshi, Suzuki, Mikio, Ide, Toshinori, Shimizu, Motoyuki, Yoshida, Mitsuaki A., Tahara, Eiichi, Shay, Jerry W., Barrett, J. Carl, Oshimura, Mitsuo“…Telomeres, at the end of chromosomes, shorten with each cell division, resulting in cellular senescence. Tumor cells, unlike normal somatic cells, express a telomerase that maintains the telomere length. …”
Publicado 1995
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1425por Sulli, Gabriele, Rommel, Amy, Wang, Xiaojie, Kolar, Matthew J., Puca, Francesca, Saghatelian, Alan, Plikus, Maksim V., Verma, Inder M., Panda, Satchidananda“…Here we show that SR9009 and SR9011, two different agonists of REV-ERBs are specifically lethal to cancer cells and oncogene-induced senescent (OIS) cells, including melanocytic naevi, while having no effect on viability of normal cells or tissues. …”
Publicado 2018
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1426por Wang, Chao, Chen, Wen-Jian, Wu, Ying-Fu, You, Pu, Zheng, Shang-Yong, Liu, Chang-Cheng, Xiang, Dao, Wang, Min-Jun, Cai, Yong-Chao, Zhao, Qing-Hui, Borjigin, Uyunbilig, Liu, Wei, Xiong, Wu-Jun, Wangensteen, Kirk J., Wang, Xin, Liu, Zhong-Min, He, Zhi-Ying“…It is well known that induction of hepatocyte senescence could inhibit the development of hepatocellular carcinoma (HCC). …”
Publicado 2018
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1427por Zheng, Hongming, Huang, Qiuju, Huang, Suchao, Yang, Xia, Zhu, Ting, Wang, Wensheng, Wang, Haojia, He, Shugui, Ji, Liyan, Wang, Ying, Qi, Xiaoxiao, Liu, Zhongqiu, Lu, Linlin“…Nevertheless, the role of senescence in tumorigenesis is controversial and few senescence inducers are extensively determined. …”
Publicado 2018
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1428por Shosha, Esraa, Xu, Zhimin, Narayanan, S. Priya, Lemtalsi, Tahira, Fouda, Abdelrahman Y., Rojas, Modesto, Xing, Ji, Fulton, David, Caldwell, R. William, Caldwell, Ruth B.“…We used Western blotting, immunolabeling, quantitative PCR, and senescence associated β-galactosidase (SA β-Gal) activity to evaluate senescence. …”
Publicado 2018
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1429“…Therefore, it is important to have insight into the senescence mechanism of Phalaenopsis. In the present study, a proteomic approach combined with ultrastructural observation and activity analysis of antioxidant enzymes was used to profile the molecular and biochemical changes during pollination-induced petal senescence in Phalaenopsis “Red Dragon”. …”
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1430por Ohashi, Minori, Korsakova, Elena, Allen, Denise, Lee, Peiyee, Fu, Kai, Vargas, Benni S., Cinkornpumin, Jessica, Salas, Carlos, Park, Jenny C., Germanguz, Igal, Langerman, Justin, Chronis, Contantinos, Kuoy, Edward, Tran, Stephen, Xiao, Xinshu, Pellegrini, Matteo, Plath, Kathrin, Lowry, William E.“…Molecular profiling uncovered neuronal-specific gene expression changes, including induction of a senescence-associated secretory phenotype (SASP) program. …”
Publicado 2018
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1431por Li, Mengxia, Yang, Xiao, Lu, Xianfeng, Dai, Nan, Zhang, Shiheng, Cheng, Yi, Zhang, Lei, Yang, Yuxin, Liu, Yie, Yang, Zhenzhou, Wang, Dong, Wilson, David M“…Unlike most other BER proteins, APE1 expression is inversely correlated with cellular senescence in primary human fibroblasts. Depletion of APE1 via shRNA induced senescence in normal human BJ fibroblasts, a phenotype that was not seen in counterpart cells expressing telomerase. …”
Publicado 2018
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1432“…Several activities appear to be shared between FOXOs and p53, including their central role in the regulation of cellular senescence. In this review, we will focus on the recent advances on the link between FOXOs and p53, with a particular focus on the FOXO4‐p53 axis and the role of FOXO4/p53 in cellular senescence. …”
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1433“…We also observed up-regulation of senescence-related genes at corresponding times. The approach we developed in this study provides a set of concepts and procedures that can be used to study reproductive synchrony experimentally under natural conditions.…”
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1435“…During aging, MSCs diminish their functional and regenerative capacities and in some cases encounter replicative senescence, promoting inflammation and cancer progression. …”
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1436por Majdi, Alireza, Sadigh-Eteghad, Saeed, Talebi, Mahnaz, Farajdokht, Fereshteh, Erfani, Marjan, Mahmoudi, Javad, Gjedde, AlbertEnlace del recurso
Publicado 2018
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1437por Alique, Matilde, Ramírez-Carracedo, Rafael, Bodega, Guillermo, Carracedo, Julia, Ramírez, Rafael“…Both aging processes produce an increase in risk factors such as oxidative stress, endothelial dysfunction and proinflammatory cytokines (oxi-inflamm-aging) that might generate endothelial senescence associated with damage in the vascular system. …”
Publicado 2018
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1438“…In this study, we assessed the safety of three anti-VEGF agents, namely, ranibizumab, bevacizumab, and aflibercept, on senescent RPE cells. METHODS: Senescent human induced pluripotent stem cell-derived RPE cells were generated by continuous replication and confirmed with senescence biomarkers. …”
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1439“…Oenothera flower petals change color during senescence. When in full bloom, the flowers of O. tetraptera are white and those of O. laciniata and O. stricta are yellow. …”
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1440“…Although to date numerous reports show the autophagy–senescence relationship, or the connection between pathogens with autophagy or senescence, the link between the three actors remains unexplored. …”
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