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  1. 1441
    por Huang, Fei
    Publicado 2018
    “…Baell et al. discovered a new class of anti-cancer drug that can put cancer cells into a permanent sleep or senescence, using high-throughput screening followed by medicinal chemistry optimization, in-cell assays, biochemical assessment of target engagement, and tumour models in mice and fish. …”
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    New KAT6 inhibitors induce senescence and arrest cancer growth
  2. 1442
    “…Cellular senescence is now considered as a major mechanism in the development and progression of various diseases and this may include metabolic diseases such as obesity and type-2 diabetes. …”
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    Obesity and type-2 diabetes as inducers of premature cellular senescence and ageing
  3. 1443
    “…It states that higher adult mortality should lead to faster and/or earlier senescence. Theoretically derived gradients, however, do not support this prediction. …”
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    Extrinsic Mortality Can Shape Life-History Traits, Including Senescence
  4. 1444
    “…Currently, cellular senescence has emerged as a fundamental contributor to chronic organ diseases. …”
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    Radiation-induced premature cellular senescence involved in glomerular diseases in rats
  5. 1445
    “…Calcium signaling is emerging as a key pathway controlling cellular senescence, a stable cell proliferation arrest playing a fundamental role in pathophysiological conditions, such as embryonic development, wound healing, cancer, and aging. …”
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    The nuclear receptor RXRA controls cellular senescence by regulating calcium signaling
  6. 1446
    “…BACKGROUND: Replicative senescence of human diploid fibroblasts (HDFs) has been used as a model to study mechanisms of cellular aging. …”
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    Proteomic profiling of senescent human diploid fibroblasts treated with gamma-tocotrienol
  7. 1447
    “…Acridine orange (AO) staining and the Lysosensor™ Green DND-189 reagents were used for indicating changes in lysosomal concentration of H(+). Changes of senescence were detected by immunoblotting of p21 and senescence-associated beta-galactosidase (SA-β-gal) staining as well as immunofluorescence assay of senescence-associated heterochromatin foci (SAHF). …”
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    A pH probe inhibits senescence in mesenchymal stem cells
  8. 1448
    “…While controlled senescence negatively regulates cell proliferation and promotes tissue regeneration, uncontrolled senescence is known to result in tissue dysfunction through enhanced secretion of inflammatory factors. …”
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    Urothelial Senescence in the Pathophysiology of Diabetic Bladder Dysfunction—A Novel Hypothesis
  9. 1449
    “…Cellular senescence displays a heterogeneous set of phenotypes linked to tumor suppression; however, after drug treatment, senescence may also be involved in stable or recurrent cancer. …”
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    Dynamic Metabolic Response to Adriamycin-Induced Senescence in Breast Cancer Cells
  10. 1450
    “…Cellular senescence is a form of cell cycle arrest that limits the proliferative potential of cells, including tumour cells. …”
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    Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2
  11. 1451
    “…Diseases of accelerated aging share common molecular pathways, which lead to the detrimental accumulation of senescent cells. These senescent cells no longer divide but release multiple inflammatory proteins, known as the senescence-associated secretory phenotype, which may perpetuate and speed disease. …”
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    MicroRNA-570 is a novel regulator of cellular senescence and inflammaging
  12. 1452
    por Zhang, Boyi, Lam, Eric W.‐F., Sun, Yu
    Publicado 2018
    “…Cellular senescence is a typical tumor‐suppressive mechanism that restricts the proliferation of premalignant cells. …”
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    Senescent cells: A new Achilles’ heel to exploit for cancer medicine?
  13. 1453
    “…In this study, we wanted to understand the mechanisms by which oxidative damage causes telomere dysfunction and senescence in human primary fibroblasts. After acute oxidative stress at telomeres, our data demonstrated a reduction in TRF1 and TRF2, which are involved in proper telomere replication and T-loop formation, respectively. …”
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    Oxidative Stress Induces Telomere Dysfunction and Senescence by Replication Fork Arrest
  14. 1454
    “…The senescence-promoting ABS3 pathway functions in parallel with the longevity-promoting autophagy to balance plant senescence and survival. …”
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    Noncanonical ATG8-ABS3 interaction controls senescence in plants
  15. 1455
    “…Here, we address the question of how senescence is induced in rarely dividing/post‐mitotic cardiomyocytes and investigate whether clearance of senescent cells attenuates age‐related cardiac dysfunction. …”
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    Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence
  16. 1456
    “…Senescence, a highly programmed process, largely determines yield and quality of crops. …”
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    Overexpression of salt-induced protein (salT) delays leaf senescence in rice
  17. 1457
    “…The offspring was generated from females Senescence Accelerated Mouse-Prone (SAMP8) fed a resveratrol-enriched diet for two months prior to mating. …”
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    Maternal Resveratrol Supplementation Prevents Cognitive Decline in Senescent Mice Offspring
  18. 1458
    “…Senescence is an important p53-controlled tumor suppressor program that not only opposes the proliferation of cancer cells but also promotes their immune-mediated clearance in certain contexts. …”
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    Natural killer cells limit the clearance of senescent lung adenocarcinoma cells
  19. 1459
    “…MicroRNAs control the gene expression responsible for plant competence to answer senescence signals. Therefore, they coordinate the juvenile-to-adult phase transition of the whole plant, the growth and senescence phase of each leaf, age-related cellular structure changes during vessel formation, and remobilization of resources occurring during senescence. …”
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    Micromanagement of Developmental and Stress-Induced Senescence: The Emerging Role of MicroRNAs
  20. 1460
    “…Collectively, these findings indicate that exhausted and senescent T cells are present at the human maternal-fetal interface and undergo alterations in a subset of women either with labor at term or preterm labor and placental inflammation. …”
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    Exhausted and Senescent T Cells at the Maternal-Fetal Interface in Preterm and Term Labor
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