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  1. 1501
    “…Typically, chondrocyte senescence is believed to serve an important role in the development and progression of OA. …”
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    Wnt/β-catenin signaling may induce senescence of chondrocytes in osteoarthritis
  2. 1502
    por Trubitsyn, Alexander G.
    Publicado 2020
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    The Mechanism of Programmed Aging: The Way to Create a Real Remedy for Senescence
  3. 1503
    “…Cellular senescence is a tumor-suppressive mechanism blocking cell proliferation in response to stress. …”
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    Cancer Stem Cell-Inducing Media Activates Senescence Reprogramming in Fibroblasts
  4. 1504
    “…Firstly, FBXO22 is a key regulator of senescence induction through ubiquitylation of p53 for degradation. …”
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    FBXO22, an epigenetic multiplayer coordinating senescence, hormone signaling, and metastasis
  5. 1505
    “…Cellular senescence is a fundamental stress response that restrains tumour formation. …”
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    Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds
  6. 1506
    por Colpani, Ornella, Spinetti, Gaia
    Publicado 2019
    “…Senescent cells stop proliferating but remain metabolically active producing pro-inflammatory signals in the environment collectively named senescence-associated secretory phenotype (SASP) that contribute to the amplification of the response to the neighbor and distant cells. …”
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    MicroRNAs orchestrating senescence of endothelial and vascular smooth muscle cells
  7. 1507
    “…As an alternative perspective on the conundrum of chronic inflammation emerging evidence points towards a small subset of senescent cells as a critical player and central node driving atherosclerosis. …”
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    Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis
  8. 1508
    “…Cellular senescence has classically been associated with aging. …”
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    Otic Neurogenesis Is Regulated by TGFβ in a Senescence-Independent Manner
  9. 1509
    “…Cellular senescence is an irreversible cell growth arrest and is associated with aging and age-related diseases. …”
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    High Phosphate Induces and Klotho Attenuates Kidney Epithelial Senescence and Fibrosis
  10. 1510
    “…Importantly, TNF-α and IFN-γ that was produced in TLR-ligand stimulated slanMo/NK cell co-cultures induced senescence in different melanoma cell lines, as indicated by reduced melanoma cell proliferation, increased senescence-associated β-galactosidase expression, p21 upregulation, and induction of a senescence-associated secretory phenotype (SASP). …”
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    Human innate immune cell crosstalk induces melanoma cell senescence
  11. 1511
    “…Here we demonstrate that baicalein and baicalin, the active components of the Chinese traditional medicinal plant Scutellaria baicalensis Georgi, can significantly inhibit melanoma cell growth and proliferation, suppress tumor cell colony formation and migration, as well as induce apoptosis and senescence in melanoma cells. The anti-tumor effects mediated by baicalein and baicalin are independent of N-RAS and B-RAF mutation statuses in melanoma cells. …”
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    Baicalein and Baicalin Promote Melanoma Apoptosis and Senescence via Metabolic Inhibition
  12. 1512
    “…Senescence is the main limitation for cut foliage display in vase. …”
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    Effects of Exogenous Putrescine on Delaying Senescence of Cut Foliage of Nephrolepis cordifolia
  13. 1513
    “…Endothelial cell senescence is one of the main risk factors contributing to vascular diseases. …”
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    Histone methyltransferase Smyd3 is a new regulator for vascular senescence
  14. 1514
    “…Photosynthates generated after heading contributes to 60% - 80% of grain yield in rice. Delay in leaf senescence can contribute to a long grain-filling period and thereby increased yield. …”
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    Unraveling candidate genomic regions responsible for delayed leaf senescence in rice
  15. 1515
    “…Finally, elimination of senescent cells from aged mice using senolytic compounds reduced Tnfsf11 mRNA in cortical bone. …”
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    Osteocyte RANKL is required for cortical bone loss with age and is induced by senescence
  16. 1516
    “…In this paper, the recent research progress on the main compounds derived from TCM and natural products that play anti‐cancer roles by inducing cell senescence is systematically reviewed, aiming to provide a reference for the clinical treatment of pro‐senescent cancer.…”
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    Cellular senescence and cancer: Focusing on traditional Chinese medicine and natural products
  17. 1517
    “…Fourth, we argue that a high senescence burst might negatively impact on vaccine efficacy. …”
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    Cellular senescence as a potential mediator of COVID‐19 severity in the elderly
  18. 1518
    “…Senescent cells negatively impact tissue regeneration while creating a pro-inflammatory environment as part of the senescence-associated secretory phenotype (SASP) favouring disease progression. …”
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    Regulation of cellular senescence by extracellular matrix during chronic fibrotic diseases
  19. 1519
    “…The premature aging phenotype observed in CKD is associated with cellular senescence, particularly of renal tubular epithelial cells (TECs), which contributes to chronic inflammation through the production of a proinflammatory senescence associated secretory phenotype (SASP). …”
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    Senescence and the Aging Immune System as Major Drivers of Chronic Kidney Disease
  20. 1520
    “…RESULTS: We found that the senescence of microglia could be induced using ionizing radiation (IR). …”
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    Regulatory coupling between long noncoding RNAs and senescence in irradiated microglia
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