“…This review focuses on the physiological, molecular, metabolic and cellular processes that drive CD8(+) T cell senescence. Evidence showing that senescent T cells hinder immunotherapies is discussed, as are therapeutic options to reverse T cell senescence.…”
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“…Inhibition of CDK4/6 can result in different cell fates such as quiescence, senescence or apoptosis. Senescence is a stress response that can be induced by stimuli that include oncogenic activation, chemotherapy, irradiation and targeted therapies such as CDK4/6 inhibitors. …”
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“…On the other hand, senolytics induce apoptosis in senescent cells allowing the remaining non–senescent population to preserve or restore tissue function. …”
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“…In this review, we focus on recent advances in the relationship between serine metabolism, antitumor immunity, and senescence. The metabolic regulation of serine seems to be a key point of intervention in antitumor immunity and aging-related disease, providing an opportunity for several novel therapeutics.…”
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“…MYSM1 functionally represses cellular senescence and the aging process in human and mice primary cells and in mice organs. …”
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“…Senescence is a state of stable proliferative arrest, generally accompanied by the senescence-associated secretory phenotype, which modulates tissue homeostasis. …”
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“…Here, we propose that the cellular localization of GIGANTEA (GI), a key clock component, regulates leaf senescence and flowering in Arabidopsis thaliana. We show that GI, which connects the circadian clock with photoperiod-regulated flowering, induces leaf senescence depending on its subcellular localization. …”
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“…Here, we examined the transcriptome induced by GmNAC81 overexpression and leaf senescence and showed that GmNAC81 further modulates leaf senescence by regulating an extensive repertoire of functionally characterized senescence-associated genes (SAGs). …”
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“…Senescent cells with replicative arrest can be generated during genotoxic, oxidative, and oncogenic stress. …”
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“…Our analysis revealed an increase in cellular senescence and mitochondrial dysfunction in BPH patient tissue compared to normal prostates. …”
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“…Removal of senescent cells from aged mice has been shown to delay aging and age–related disabilities. …”
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“…GA reduced the G0/G1 phase in senescent REF cells that led cells to G2/M. Besides, GA improved the function of the β cells. …”
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“…In this article, we review the mechanisms mediating apoptosis and senescence during early embryo development, with a focus on in vitro produced bovine embryos. …”
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“…This form of senescence is termed therapy-induced senescence (TIS) and represents a desirable target in cancer therapy. …”
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“…Importantly, ATM kinase plays a central role in the DDR, and it can finely tune the balance between senescence and apoptosis: activated ATM promotes autophagy and in particular sustains the lysosomal-mitochondrial axis, which in turn promotes senescence and inhibits apoptosis. …”
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“…Overall, the results revealed a strong connection with stress induced senescence, significant miRNA targets for cell cycle arrest, and many common signaling pathways to GBM in the network.…”
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“…The progressive mitochondrial damage induced by HIV-infection and ART-treatment likely contributes to accelerated aging, senescence, and cellular dysfunction in PLHIV. This review discusses the connections between mitochondrial compromise and cellular dysfunction associated with HIV- and ART-induced toxicities, providing new insights into how HIV and current ART directly impact mitochondrial functions and contribute to cellular senescence and aging in PLHIV. …”
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“…BACKGROUND & AIMS: The association between cellular senescence and Helicobacter pylori–induced atrophic gastritis is not clear. …”
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“…SIMPLE SUMMARY: Cellular senescence consists of a permanent block of cell proliferation in the presence of an active metabolism. …”
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“…It has been revealed that the cause of senescence and diseases is associated with the reactive oxygen species “hydroxyl radicals” (·OH). …”
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