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  1. 1541
    “…Thus, better understanding of cellular senescence in immune populations at single‐cell level may provide us with insight into how immune cell senescence develops over the life time of an individual. …”
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    Hallmarks and detection techniques of cellular senescence and cellular ageing in immune cells
  2. 1542
    por Chen, Yuping, Futcher, Bruce
    Publicado 2020
    “…We consider recent results suggesting that increased cell size causes senescence, and suggest that at very large sizes, an excess of DNA binding proteins leads to size induced senescence.…”
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    Scaling gene expression for cell size control and senescence in Saccharomyces cerevisiae
  3. 1543
    “…Cellular senescence can either support or inhibit cancer progression. …”
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    Senescent Tumor Cells Build a Cytokine Shield in Colorectal Cancer
  4. 1544
    por Mejías-Luque, Raquel
    Publicado 2020
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    Senescence: A Novel Driver of Helicobacter pylori–Induced Gastric Atrophy
  5. 1545
    “…Here, we review the main findings on the mechanisms controlling physiological vascular sprouting, proliferation, and senescence and how those mechanisms are often deregulated in acquired or congenital cardiovascular disease leading to a diverse range of pathologies. …”
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    Endothelial sprouting, proliferation, or senescence: tipping the balance from physiology to pathology
  6. 1546
    “…Social insects are intriguing models for analysing the relationship between oxidative stress and senescence because life histories differ vastly between long-lived reproductives and the genetically similar but short-lived workers. …”
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    Oxidative stress and senescence in social insects: a significant but inconsistent link?
  7. 1547
    “…Irradiated osteocytes were shown to exhibit notable DNA damage, which resulted in the initiation of a typical cellular senescence phenotype. Furthermore, it was found that irradiation-induced prematurely senescent osteocytes stimulate molecular secretion, referred to as senescence-associated secretory phenotype (SASP), which may be involved in modulation of the bone microenvironment, including the promotion of osteoclastogenesis. …”
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    Radiation induces primary osteocyte senescence phenotype and affects osteoclastogenesis in vitro
  8. 1548
    por Yan, Chi, Xu, Zhimeng, Huang, Weiqiang
    Publicado 2021
    “…This review summarizes the processes of angiogenesis, myogenesis and cellular senescence after IHD. In addition, this review focuses on the relationship between cellular senescence and cardiovascular disease and the mechanism of cellular senescence. …”
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    Cellular Senescence Affects Cardiac Regeneration and Repair in Ischemic Heart Disease
  9. 1549
    “…However, whether this variation in senescence levels, in different aged populations, translation to COVID-19 infection is unknown. …”
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    An Account of Immune Senescence in the Clinical Pathophysiology of COVID-19 Infection in Aging
  10. 1550
    por Ferrari, Silvia, Pesce, Maurizio
    Publicado 2021
    “…In this review, we will describe the effects of senescence on tissue structure, extracellular matrix (ECM) organization, and nucleus architecture, and see how these changes affect (are affected by) mechano-transduction. …”
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    Stiffness and Aging in Cardiovascular Diseases: The Dangerous Relationship between Force and Senescence
  11. 1551
    por Huang, Zhusong, Lan, Jinfu, Gao, Xi
    Publicado 2021
    “…Cellular senescence was assessed using senescence-associated β-galactosidase (SA-β-Gal) staining. …”
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    Feprazone Mitigates IL-1β-Induced Cellular Senescence in Chondrocytes
  12. 1552
    “…Telomere shortening results in cellular senescence and the regulatory mechanisms remain unclear. …”
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    Sir4 Deficiency Reverses Cell Senescence by Sub-Telomere Recombination
  13. 1553
    “…Darkness-mediated premature leaf senescence is a well-studied stressor. It initiates the expression of senescence-associated genes (SAGs), which have been implicated in chlorophyll breakdown and degradation. …”
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    Low Light/Darkness as Stressors of Multifactor-Induced Senescence in Rice Plants
  14. 1554
    “…Cellular senescence is characterized by an irreversible cell cycle arrest as well as a pro‐inflammatory phenotype, thought to contribute to aging and age‐related diseases. …”
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    Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner
  15. 1555
    “…The aim of this study was to evaluate cellular senescence (CS) marker expression in cholangiocytes of patients with PSC and their correlation with clinical–pathological features and prognosis. …”
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    Cholangiocyte senescence in primary sclerosing cholangitis is associated with disease severity and prognosis
  16. 1556
    “…Here, we show that midbrain dopamine (DA) neurons derived from human pluripotent stem cells (hPSCs) are selectively permissive to SARS-CoV-2 infection both in vitro and upon transplantation in vivo, and that SARS-CoV-2 infection triggers a DA neuron inflammatory and cellular senescence response. A high-throughput screen in hPSC-derived DA neurons identified several FDA approved drugs, including riluzole, metformin, and imatinib, that can rescue the cellular senescence phenotype and prevent SARS-CoV-2 infection. …”
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    SARS-CoV-2 Infection Causes Dopaminergic Neuron Senescence
  17. 1557
    “…Hyperoxia is also known to dysregulate p53, senescence, and metabolism. However, whether these changes in p53, senescence, and metabolism are intertwined in response to hyperoxia is still unknown. …”
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    Hyperoxia causes senescence and increases glycolysis in cultured lung epithelial cells
  18. 1558
    “…The aim of this study was to explore senescence pathways in aldosterone-producing cells and related disorders, and the influence of aldosterone overproduction on in situ senescence. …”
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    Cellular Senescence in Human Aldosterone-Producing Adrenocortical Cells and Related Disorders
  19. 1559
    “…Mannitol 20 mmol/L used in the same scenario as glucose did not induce HREC senescence. In HREC exposed to GLU and SUL, the senescent changes were smaller. …”
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    Sulodexide reduces glucose induced senescence in human retinal endothelial cells
  20. 1560
    “…Cellular senescence is a state of irreversible cell cycle arrest that has important physiological functions. …”
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    Evaluating causality of cellular senescence in non-alcoholic fatty liver disease
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