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1621por Kuehnemann, Chisaka, Hu, Kang-Quan, Butera, Kayla, Patel, Sandip K., Bons, Joanna, Schilling, Birgit, Aguayo-Mazzucato, Cristina, Wiley, Christopher D.“…This senescence-associated secretory phenotype (SASP) underlies many of the degenerative and regenerative aspects of cellular senescence - including promoting wound healing and development, but also driving diabetes and multiple age-associated diseases. …”
Publicado 2022
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1622por O’hara, Kelsey, Mullen, Michael, Oberlohr, Verena, Hambright, Sealy, Huard, Johnny, Duke, Victoria“…Fundamental aging processes may be root cause contributors to all these disorders, and among these mechanisms is cellular senescence. These cells can release pro-inflammatory cytokines/chemokines and other factors, otherwise known as the senescence-associated secretory phenotype (SASP). …”
Publicado 2022
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1623por Liebsch, Daniela, Juvany, Marta, Li, Zhonghai, Wang, Hou-Ling, Ziolkowska, Agnieszka, Chrobok, Daria, Boussardon, Clément, Wen, Xing, Law, Simon R, Janečková, Helena, Brouwer, Bastiaan, Lindén, Pernilla, Delhomme, Nicolas, Stenlund, Hans, Moritz, Thomas, Gardeström, Per, Guo, Hongwei, Keech, Olivier“…Leaf senescence can be induced by stress or aging, sometimes in a synergistic manner. …”
Publicado 2022
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1624por Malavolta, Marco, Giacconi, Robertina, Piacenza, Francesco, Strizzi, Sergio, Cardelli, Maurizio, Bigossi, Giorgia, Marcozzi, Serena, Tiano, Luca, Marcheggiani, Fabio, Matacchione, Giulia, Giuliani, Angelica, Olivieri, Fabiola, Crivellari, Ilaria, Beltrami, Antonio Paolo, Serra, Alessandro, Demaria, Marco, Provinciali, Mauro“…Cellular senescence is a hallmark of aging and a promising target for therapeutic approaches. …”
Publicado 2022
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1625“…Previously, we showed that TMZ induces not only apoptosis and autophagy, but also cellular senescence (CSEN). We presented the hypothesis that GBM cells may escape from CSEN, giving rise to recurrent tumors. …”
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1626“…Cholinergic neurons in the Ts65Dn mice display overexpression of the early expression gene c-fos and an increase in the expression of β-galactosidase, a marker of senescence. A possible mechanism for senescence induction could be phosphorylation of the transcription factor FOXO1 and its retention in the cytoplasm, which we are able to confirm in the Ts65Dn model. …”
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1627“…In recent years, the systemic accumulation of senescent cells has emerged as a key mediator of many age-related declines and diseases of aging. …”
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1628“…We propose herein a mechanistic classification of senolytic drugs, based on the level at which they target senescent cells: directly disrupting BH3 protein networks that are reorganized upon senescence induction; downregulating survival-associated pathways essential to senescent cells; or modulating homeostatic processes whose regulation is challenged in senescence. …”
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1629por Urista, Juan, Maldonado, Mariel, Toscano-Marquez, Fernanda, Ramírez, Remedios, Balderas-Martínez, Yalbi Itzel, Becerril, Carina, Romero, Yair, Selman, Moisés, Pardo, Annie“…Silencing ZNF365 in human lung fibroblasts and alveolar epithelial cells induced a significant reduction of growth rate and increased senescence markers, including Senescence Associated β Galactosidase activity, p53, p21, and the histone variant γH2AX. …”
Publicado 2022
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1630“…In this context, cellular senescence functions as a tumour suppressor mechanism. …”
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1631“…Senescence in plants enables resource recycling from senescent leaves to sink organs. …”
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1632por Miller, William, Pruett, Charles Lewis Humphrey, Stone, William, Eide, Cindy, Riddle, Megan, Popp, Courtney, Yousefzadeh, Matthew, Lees, Christopher, Seelig, Davis, Thompson, Elizabeth, Orr, Harry, Niedernhofer, Laura, Tolar, Jakub“…Since DNA damage can lead to accumulation of senescent cells, we hypothesized that SCA7 causes an accumulation of senescent cells over the course of disease. …”
Publicado 2022
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1633“…The senescence-associated secretory phenotype (SASP), which accumulates over the course of normal aging and in age-related diseases, is a crucial driver of chronic inflammation and aging phenotypes. …”
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1634por Kaur, Prameet, Otgonbaatar, Agimaa, Ramamoorthy, Anupriya, Chua, Ellora Hui Zhen, Harmston, Nathan, Gruber, Jan, Tolwinski, Nicholas S.“…We know that as organisms age, stem cell pools are exhausted while senescent cells progressively accumulate. Independently, induction of pluripotency via expression of Yamanaka factors (Oct4, Klf4, Sox2, c-Myc; OKSM) and clearance of senescent cells have each been shown to ameliorate cellular and physiological aspects of aging, suggesting that both processes are drivers of organismal aging. …”
Publicado 2022
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1636por Yildiz, Ozlem, Schroth, Johannes, Tree, Timothy, Turner, Martin R., Shaw, Pamela J., Henson, Sian M., Malaspina, Andrea“…In this single-center, retrospective study, we investigated the expression of senescent-like blood mononuclear cells in ALS. METHODS: We first applied multidimensional cytometry by time-of-flight (CyTOF) to study the senescent immunophenotype of blood mononuclear cells from 21 patients with ALS and 10 healthy controls (HCs). …”
Publicado 2022
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1637Phytocannabinoids Stimulate Rejuvenation and Prevent Cellular Senescence in Human Dermal Fibroblastspor Gerasymchuk, Marta, Robinson, Gregory Ian, Groves, Alyssa, Haselhorst, Lucie, Nandakumar, Sanjana, Stahl, Cora, Kovalchuk, Olga, Kovalchuk, Igor“…Utilizing healthy and stress-induced premature senescent (SIPS) CCD-1064Sk skin fibroblasts, the effects of pCBs on cellular viability, functional activity, metabolic function, and nuclear architecture were tested. …”
Publicado 2022
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1638por Kallenbach, Julia, Atri Roozbahani, Golnaz, Heidari Horestani, Mehdi, Baniahmad, Aria“…CONCLUSION: Thus, dependent on the type of senescence inducer and the specific senescence-induced cellular pathway, it is useful to develop pathway-specific senolytic compounds to specifically targeting senescent cells in order to evict senescent cells and thereby to reduce SASP side effects.…”
Publicado 2022
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1639“…The aging-related loss of organ performance is largely driven by the increase in senescent cells. To date, the hallmarks and molecular mechanisms related to cellular senescence are not fully understood. …”
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