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1721por Passos, João F, Nelson, Glyn, Wang, Chunfang, Richter, Torsten, Simillion, Cedric, Proctor, Carole J, Miwa, Satomi, Olijslagers, Sharon, Hallinan, Jennifer, Wipat, Anil, Saretzki, Gabriele, Rudolph, Karl Lenhard, Kirkwood, Tom B L, von Zglinicki, Thomas“…The pathways leading to establishment of senescence are proving to be more complex than was previously envisaged. …”
Publicado 2010
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1722por Brondello, Jean-Marc, Philipot, Didier, Djouad, Farida, Jorgensen, Christian, Noël, Danièle“…In this study, we review a number of molecular factors associated with the senescent phenotype. CONCLUSION: Whereas accumulation of senescent cells in preneoplasic-like lesions leads to tissue degeneration and potentially tumour development; in OA, senescent cells accumulate in a slowly proliferative tissue. …”
Publicado 2010
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1723por Gutierrez-Reyes, Gabriela, Garcia de Leon, Maria del Carmen, Varela-Fascinetto, Gustavo, Valencia, Pedro, Pérez Tamayo, Ruy, Rosado, Claudia Gonzalez, Labonne, Blanca Farfan, Rochilin, Norma Morales, Garcia, Rosalinda Martinez, Valadez, Jonathan Aguirre, Latour, Gabriela Togno, Corona, Dana Lau, Diaz, Guillermo Robles, Zlotnik, Albert, Kershenobich, DavidEnlace del recurso
Publicado 2010
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1724“…CONCLUSIONS/SIGNIFICANCE: We conclude that: (1) Hsp90 inhibition primarily induces premature senescence, rather than cell death, in small cell lung cancer cells; (2) small cell lung cancer cells can bypass this senescence through further genetic alterations; (3) Hsp90 inhibitor-induced cell death in small cell lung cancer cells is due to inhibition of a target other than cytosolic Hsp90. …”
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1725“…BACKGROUND: Senescence has been widely detected among mammals, but its importance to fitness in wild populations remains controversial. …”
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1728por Deruy, Emeric, Gosselin, Karo, Vercamer, Chantal, Martien, Sébastien, Bouali, Fatima, Slomianny, Christian, Bertout, Julie, Bernard, David, Pourtier, Albin, Abbadie, Corinne“…Senescence is a state of growth arrest resulting mainly from telomere attrition and oxidative stress. …”
Publicado 2010
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1729por Zhao, Hong, Halicka, H Dorota, Traganos, Frank, Jorgensen, Ellen, Darzynkiewicz, Zbigniew“…The imaging analytical capabilities of laser scanning cytometer (LSC) have been used to assess morphological features considered to be typical of the senescent phenotype. The characteristic “flattening” of senescent cells was reflected by the decline in the density of staining (intensity of maximal pixel) of DNA-associated fluorescence [4,6-diamidino-2-phenylindole (DAPI)] paralleled by an increase in nuclear size (area). …”
Publicado 2010
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1730por Balin, Arthur K., Reimer, Richard J., Reenstra, Wende R., Lilie, Steven M., Leong, Ina, Sullivan, Katherine, Allen, Robert G.“…MnSOD activity was significantly higher in senescent cultures than in early passage cultures and was also responsive to increased oxygen tension in senescent cultures. …”
Publicado 2010
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1731por Wang, Chunfang, Maddick, Mandy, Miwa, Satomi, Jurk, Diana, Czapiewski, Rafal, Saretzki, Gabriele, Langie, Sabine A.S., Godschalk, Roger W.L., Cameron, Kerry, von Zglinicki, Thomas“…We show for the first time that adult-onset, short-term DR reduced frequencies of senescent cells in the small intestinal epithelium and liver of mice, which are tissues known to accumulate increased numbers of senescent cells with advancing age. …”
Publicado 2010
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1732“…Conversely, cellular senescence constitutes a failsafe program against cancer progression. …”
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1734“…Mouse embryonic fibroblasts (MEFs) are commonly grown in cell culture and are known to enter senescence after a low number of passages as a result of oxidative stress. …”
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1735por Varecza, Zoltan, Kvell, Krisztian, Talabér, Gergely, Miskei, Gyorgy, Csongei, Veronika, Bartis, Domokos, Anderson, Graham, Jenkinson, Eric J., Pongracz, Judit E.“…Down-regulation of Wnt-4 expression and activation of multiple repressor pathways suppressing β-catenin dependent signalling in TECs contribute to the initiation of thymic senescence.…”
Publicado 2011
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1736por Leontieva, Olga V., Demidenko, Zoya N., Gudkov, Andrei V., Blagosklonny, Mikhail V.“…BACKGROUND: Depending on cellular context, p53-inducing agents (such as nutlin-3a) cause different outcomes including reversible quiescence and irreversible senescence. Inhibition of mTOR shifts the balance from senescence to quiescence. …”
Publicado 2011
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1737“…CONCLUSION: Src homology domain-containing phosphatase 2 promotes the growth of glioblastoma cells by suppression of cellular senescence, a phenomenon not described previously. Selective inhibitors of SHP2 are commercially available and may be considered as a strategy for glioblastoma therapy.…”
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1738“…In yeast, chronological senescence (CS) is defined as loss of viability in stationary culture. …”
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1739Genome-Wide Evaluation of Histone Methylation Changes Associated with Leaf Senescence in Arabidopsispor Brusslan, Judy A., Rus Alvarez-Canterbury, Ana M., Nair, Nishanth Ulhas, Rice, Judd C., Hitchler, Michael J., Pellegrini, Matteo“…Approximately 50% of senescence up-regulated genes lacked the H3K4me3 mark in both mature and senescent leaf tissue. …”
Publicado 2012
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1740“…Here we discuss a recently published study from our group on how a continuous CD4 T-cell dependent immune clearance of premalignant senescent cells, designated “senescence surveillance,” restricts liver cancer development.…”
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