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  1. 1741
    “…During further cell passaging, an increasing number of cells become cell cycle arrested and finally senescent. This transition from proliferating to senescent cells is driven by a number of endogenous and exogenous stress factors. …”
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    Quantitative Model of Cell Cycle Arrest and Cellular Senescence in Primary Human Fibroblasts
  2. 1742
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    Too much or too little: Harnessing senescence to control oncogene-driven cancer
  3. 1743
    por Ohshima, Susumu
    Publicado 2012
    “…We previously showed that abnormal mitotic cells with supernumerary centrosomes increase with replicative senescence in human fibroblasts, especially in a polyploid subpopulation. …”
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    Centrosome Aberrations Associated with Cellular Senescence and p53 Localization at Supernumerary Centrosomes
  4. 1744
    “…Increased protein modification has also been described upon replicative senescence of human fibroblasts, a valid model for studying aging in vitro. …”
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    Protein Oxidative Damage at the Crossroads of Cellular Senescence, Aging, and Age-Related Diseases
  5. 1745
    por Gu, Liubao, Kitamura, Masanori
    Publicado 2012
    “…Senescence-associated secretory phenotype (SASP) is characterized by abundant secretion of various proteins in senescent cells and implicated in tumor progression and inflammatory responses. …”
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    Sensitive Detection and Monitoring of Senescence-Associated Secretory Phenotype by SASP-RAP Assay
  6. 1746
    por Cahu, J, Bustany, S, Sola, B
    Publicado 2012
    “…Following genotoxic stress, remaining DNA damages lead to a senescence-associated secretory phenotype (SASP). Senescent cells, which are the non-CSLCs, secrete chemokines contributing to the emergence, maintenance and migration of CSLCs. …”
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    Senescence-associated secretory phenotype favors the emergence of cancer stem-like cells
  7. 1747
    “…Pluripotent stem cells evade replicative senescence, whereas other primary cells lose their proliferation and differentiation potential after a limited number of cell divisions, and this is accompanied by specific senescence-associated DNA methylation (SA-DNAm) changes. …”
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    Pluripotent stem cells escape from senescence-associated DNA methylation changes
  8. 1748
    “…Further, we found that Sox2-induced-autophagy enhanced cellular senescence by up-regulating tumor suppressors or senescence factors, including p16(INK4a), p21 and phosphorylated p53 (Ser15). …”
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    Autophagy and Cellular Senescence Mediated by Sox2 Suppress Malignancy of Cancer Cells
  9. 1749
    “…To determine whether altered LMNB1 levels cause senescence, we either increased or reduced LMNB1. Both LMNB1 depletion and overexpression inhibited proliferation, but only LMNB1 overexpression induced senescence, which was prevented by telomerase expression or inactivation of p53. …”
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    Lamin B1 fluctuations have differential effects on cellular proliferation and senescence
  10. 1750
    “…RESULTS: We demonstrated that myeloma bone marrow mesenchymal stromal cells have an increased expression of senescence-associated β-galactosidase, increased cell size, reduced proliferation capacity and characteristic expression of senescence-associated secretory profile members. …”
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    Evidences of Early Senescence in Multiple Myeloma Bone Marrow Mesenchymal Stromal Cells
  11. 1751
    “…BACKGROUND: Recent studies have demonstrated that cellular energy is a key factor switching on ripening and senescence of fruit. However, the factors that influence fruit energy status remain largely unknown. …”
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    Energy status of ripening and postharvest senescent fruit of litchi (Litchi chinensis Sonn.)
  12. 1752
    “…Functionally, miR-22 overexpression induced cellular senescence and promoted migratory activity of cardiac fibroblasts. …”
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    MicroRNA-22 increases senescence and activates cardiac fibroblasts in the aging heart
  13. 1753
    por Teixeira, M. Teresa
    Publicado 2013
    “…Hence, replicative senescence has been considered one of the most potent tumor suppressor pathways. …”
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    Saccharomyces cerevisiae as a Model to Study Replicative Senescence Triggered by Telomere Shortening
  14. 1754
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    Muscular senescence in cetaceans: adaptation towards a slow muscle fibre phenotype
  15. 1755
    por Jones, Michelle L.
    Publicado 2013
    “…Gene expression studies indicate that remobilization is a key feature of senescence, but some senescence-associated genes have different expression in leaves and petals. …”
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    Mineral nutrient remobilization during corolla senescence in ethylene-sensitive and -insensitive flowers
  16. 1756
    “…It also affects estrogen activity, which reduces EPC senescence. Sun ginseng (SG), which is heat-processed ginseng, has a high content of ginsenosides. …”
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    Sun Ginseng Protects Endothelial Progenitor Cells From Senescence Associated Apoptosis
  17. 1757
    “…Overactivation of these sensory signal transduction pathways can cause cellular senescence, age-related diseases, including cancer, and shorten life span. …”
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    Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes
  18. 1758
    “…The photooxidation of cellular monounsaturated fatty acids was investigated in senescent phytoplanktonic cells (Emiliania huxleyi) and in their attached bacteria under laboratory controlled conditions. …”
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    Photochemical Production and Behavior of Hydroperoxyacids in Heterotrophic Bacteria Attached to Senescent Phytoplanktonic Cells
  19. 1759
    “…The anti-fibrotic action of rupatadine might relate to its attenuation of BLM- or PAF-induced premature senescence because rupatadine treatment protected against the in vivo and in vitro activation of the p53/p21-dependent senescence pathway. …”
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    Rupatadine Protects against Pulmonary Fibrosis by Attenuating PAF-Mediated Senescence in Rodents
  20. 1760
    por Brosens, Jan J., Lam, Eric W.-F.
    Publicado 2013
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    Progesterone and FOXO1 signaling: Harnessing cellular senescence for the treatment of ovarian cancer
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