Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Jagged1-Notch2 interactions are known to be crucial for intrahepatic biliary tract development, but the Notch signaling pathway is also involved in the juxtacrine transmission of senescence and in the induction and modulation of the senescence-associated secretory phenotype (SASP). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The changed specificity of senescent astrocytes is largely due to their altered gene expression. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The senescence of vascular endothelial cells (VECs) drives the occurrence and development of cardiovascular disease (CVD). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Cellular senescence describes a stable cell cycle arrest state with a characteristic phenotype. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The drivers include a persistent DNA damage response causing multiple alterations in cellular function. Senescent cells secrete a range of mediators that drive chronic inflammation and can convert other cells to the senescent state—the senescence-associated secretory phenotype. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Senescent cells accumulate in multicellular animals with aging, resulting in organ or tissue dysfunction. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Leaf senescence, the last stage of leaf development, is a type of postmitotic senescence and is characterized by the functional transition from nutrient assimilation to nutrient remobilization which is essential for plants’ fitness. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We point out approaches for senescent-lymphocyte-targeting markers using small molecules (senolytics), antibodies and immunization against senescent cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…INTRODUCTION: Obligate autoscopic mirror hallucinations of senescence have not heretofore been described. OBJECTIVES: To reveal that perception of looking older in the mirror may be the manifestation of Mirror Autoprosopometamorphopsia. …”
Enlace del recurso
Enlace del recurso

“…We have used gene-expression analysis and polymorphism screening to study molecular senescence of the retina and hippocampus in two rare inbred mouse models of accelerated neurological senescence (SAMP8 and SAMP10) that closely mimic human neurological aging, and in a related normal strain (SAMR1) and an unrelated normal strain (C57BL/6J). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Two independent lines of experimental evidence are presented in support of the hypothesis that senescence is a normal mechanism of tumor suppression, a homeostatic device designed through evolution to limit cell proliferation irreversibly and thereby to protect the organism against cancer. …”
Enlace del recurso
Enlace del recurso

“…It is suggested that this process is responsible for ultimate replicative senescence and yet it is compatible with long-term cell survival.…”
Enlace del recurso
Enlace del recurso

“…In contrast their number of cell divisions preceding senescence is limited underin vitro culture conditions. …”
Enlace del recurso
Enlace del recurso

“…The new link between autophagy and senescence provides an insight into the diversified downstream effects of autophagy in various cellular contexts.…”
Enlace del recurso
Enlace del recurso

“…Consistent with this, a senescent-like state can develop in preadipocytes and fat cells from young obese individuals. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…By broad literature survey, we have developed a leaf senescence database (LSD, http://www.eplantsenescence.org/) that contains a total of 1145 senescence associated genes (SAGs) from 21 species. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Neutrophil functions are limited by a process of neutrophil senescence, which renders the cells unable to respond to chemoattractants, carry out respiratory burst, or degranulate. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here, we for the first time link AR anti-cancer action with cell senescence in vitro and in vivo. First, AR-driven senescence was p53-independent. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

Enlace del recurso
Enlace del recurso