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  1. 1821
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    Autofluorescence as a measure of senescence in C. elegans: look to red, not blue or green
  2. 1822
    “…Senescence, a terminal cell proliferation arrest that is caused by a variety of cellular stresses such as telomere erosion, DNA damage and oncogenic signaling, is classically considered a tumor defense barrier. …”
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    Upregulation of SOX4 antagonizes cellular senescence in esophageal squamous cell carcinoma
  3. 1823
    “…The need for in vitro propagation to obtain therapeutic quantities of the cells imposes a risk of impaired functionality due to cellular senescence. The aim of the study was to analyze in vitro senescence of previously cryopreserved human ADSCs subjected to serial passages in cell culture. …”
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    Characterization of Senescence of Culture-expanded Human Adipose-derived Mesenchymal Stem Cells
  4. 1824
    “…We observe that, together with p63, FOXM1 strongly contributes to the maintenance of high proliferative potential in keratinocytes, whereas its expression decreases during differentiation, as well as during replicative-induced senescence. Depletion of FOXM1 is sufficient to induce keratinocyte senescence, paralleled by an increased ROS production and an inhibition of ROS-scavenger genes (SOD2, CAT, GPX2, PRDX). …”
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    FOXM1 regulates proliferation, senescence and oxidative stress in keratinocytes and cancer cells
  5. 1825
    “…BACKGROUND: Human mesenchymal stem cells (MSC), during in vitro expansion, undergo a progressive loss of proliferative potential that leads to the senescent state, associated with a reduction of their “medicinal” properties. …”
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    Detection of mesenchymal stem cells senescence by prelamin A accumulation at the nuclear level
  6. 1826
    “…We showed that NFATc1 activation led to acceleration of Pten-null–driven prostate tumorigenesis by overcoming the PTEN loss–induced cellular senescence through inhibition of p21 activation. This study provides direct in vivo evidence of an oncogenic role of NFATc1 in prostate tumorigenesis and reveals multiple functions of NFATc1 in activating oncogenes, in inducing proinflammatory cytokines, in oncogene addiction, and in overcoming cellular senescence, which suggests calcineurin-NFAT signaling as a potential target in preventing PCa.…”
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    NFATc1 Promotes Prostate Tumorigenesis and Overcomes PTEN Loss-Induced Senescence
  7. 1827
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    Revisiting the Debate: Does Exercise Build Strong Bones in the Mature and Senescent Skeleton?
  8. 1828
    “…In this study, to estimate the oxidative stress level in senescence-accelerated mouse prone 8 (SAMP8), we evaluated serum reactive oxygen species production and reduction capacity by measurement of Diacron-Reactive Oxygen Metabolites (d-ROM) and Biological Antioxidant Potential (BAP), respectively, with age. …”
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    Age-dependency of the serum oxidative level in the senescence-accelerated mouse prone 8
  9. 1829
    “…Using Caenorhabditis elegans as a model, we show here that depletion of BRC‐2, an ortholog of BRCA2, paradoxically delays senescence in telomerase‐deficient mutant worms. Telomerase‐deficient worms (trt‐1) exhibit early replication senescence due to short telomeres. …”
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    Paradoxical delay of senescence upon depletion of BRCA2 in telomerase‐deficient worms
  10. 1830
    “…In these conditions, senescent cells are often observed and is involved in the generation of inflammation. …”
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    Activated Factor X Induces Endothelial Cell Senescence Through IGFBP-5
  11. 1831
    “…Senescence of cardiac myocytes is frequently associated with heart diseases. …”
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    Cell Electrical Impedance as a Novel Approach for Studies on Senescence Not Based on Biomarkers
  12. 1832
    “…BACKGROUND: Senescence is a key developmental process occurring during the life cycle of plants that can be induced also by environmental conditions, such as starvation and/or darkness. …”
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    Flavonoids and darkness lower PCD in senescing Vitis vinifera suspension cell cultures
  13. 1833
    “…To specifically analyze changes in macroautophagy (MA) we quantified different autophagy-related proteins (ATGs) in young, adult and old murine tissue as well as in young and senescent human fibroblasts. Thus, we revealed significantly reduced levels of ATG5-ATG12, LC3-II/LC3-I ratio, Beclin-1 and p62 in old brain tissue and senescent human fibroblasts. …”
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    Macroautophagy is impaired in old murine brain tissue as well as in senescent human fibroblasts
  14. 1834
    “…Whether programmed senescence exists in cardiac organogenesis has not ever been reported. …”
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    Pax8 plays a pivotal role in regulation of cardiomyocyte growth and senescence
  15. 1835
    “…Cd treatment significantly increased senescence in neuronal cells, which was aggravated by 3-MA or silencing of Atg5 and abolished by rapamycin. …”
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    The ER stress regulator Bip mediates cadmium-induced autophagy and neuronal senescence
  16. 1836
    “…Unfortunately, these cells undergo replicative senescence rapidly by mechanisms that are not well understood. …”
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    Mitochondrial Functional Changes Characterization in Young and Senescent Human Adipose Derived MSCs
  17. 1837
    “…Eight protease knock-out lines and two protease over expressing lines were subjected to senescence phenotype analysis to determine the importance of individual protease activities to senescence. …”
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    Major Cys protease activities are not essential for senescence in individually darkened Arabidopsis leaves
  18. 1838
    por Yosef, Reut, Krizhanovsky, Valery
    Publicado 2016
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    mTOR signaling orchestrates the expression of cytoprotective factors during cellular senescence
  19. 1839
    “…Replicative senescence has a major impact on function and integrity of cell preparations. …”
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    Senescence‐associated DNA methylation is stochastically acquired in subpopulations of mesenchymal stem cells
  20. 1840
    “…Cellular senescence is a stable cell cycle arrest that is the causative process of aging. …”
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    Identification of Salvia haenkei as gerosuppressant agent by using an integrated senescence-screening assay
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