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  1. 1841
    “…While cellular senescence is a critical mechanism to prevent malignant transformation of potentially mutated cells, persistence of senescent cells can also promote cancer and aging phenotypes. …”
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    Altered stoichiometry and nuclear delocalization of NonO and PSF promote cellular senescence
  2. 1842
    “…Senescence-associated β-galactosidase (SA β-gal) activity, inflammation, and cellular proliferation were determined in the prostate. …”
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    Parental High-Fat Diet Promotes Inflammatory and Senescence-Related Changes in Prostate
  3. 1843
    “…Leaf senescence is influenced by its life history, comprising a series of developmental and physiological experiences. …”
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    High-Throughput and Computational Study of Leaf Senescence through a Phenomic Approach
  4. 1844
    “…Senescence is a stress response characterized by an irreversible growth arrest and alterations in certain cell functions. …”
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    NOX4 downregulation leads to senescence of human vascular smooth muscle cells
  5. 1845
    “…However, the impact of S6 kinase activity on cellular senescence remains to be established. Here, we show that the constitutive activation of mammalian target of rapamycin complex 1 (mTORC1) by tuberous sclerosis complex (TSC) mutations induces a premature senescence programme in fibroblasts that relies on S6 kinases. …”
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    ZRF1 is a novel S6 kinase substrate that drives the senescence programme
  6. 1846
    “…However, because of the lack of proper senescence models, exploration of the underlying molecular mechanisms has been hindered. …”
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    Drug-induced premature senescence model in human dental follicle stem cells
  7. 1847
    “…Cellular senescence is known as an anti-tumor barrier and is characterized by a number of determinants including cell cycle arrest, senescence associated β-galactosidase activity and secretion of pro-inflammatory mediators. …”
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    ATF6α regulates morphological changes associated with senescence in human fibroblasts
  8. 1848
    “…Cellular senescence is an important in vivo mechanism that prevents the propagation of damaged cells. …”
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    Integrin Beta 3 Regulates Cellular Senescence by Activating the TGF-β Pathway
  9. 1849
    “…OBJECTIVE: Premature senescence of lymphocytes is a hallmark of inflammatory rheumatic diseases such as rheumatoid arthritis (RA). …”
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    Novel Senescent Regulatory T-Cell Subset with Impaired Suppressive Function in Rheumatoid Arthritis
  10. 1850
    “…In response to DNA damage, a cell can be forced to permanently exit the cell cycle and become senescent. Senescence provides an early barrier against tumor development by preventing proliferation of cells with damaged DNA. …”
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    Residual Cdk1/2 activity after DNA damage promotes senescence
  11. 1851
    “…The senescence-accelerated mouse prone 8 (SAMP8) model is characterized by accelerated, progressive cognitive decline as well as Alzheimer’s disease (AD)-like neurodegenerative changes, and resembles the etiology of multicausal, sporadic late-onset/age-related AD in humans. …”
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    Slow and Fast Neocortical Oscillations in the Senescence-Accelerated Mouse Model SAMP8
  12. 1852
    “…We examine the antioxidant role of young and senescent human umbilical vein endothelial cells (HUVECs) and their microvesicles (MVs). …”
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    The Antioxidant Machinery of Young and Senescent Human Umbilical Vein Endothelial Cells and Their Microvesicles
  13. 1853
    “…In the present study we investigated the role of H(2)S in ethylene-promoted banana ripening and senescence by the application of ethylene released from 1.0 g·L(−1) ethephon solution or H(2)S with 1 mM sodium hydrosulfide (NaHS) as the donor or in combination. …”
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    Hydrogen sulfide alleviates postharvest ripening and senescence of banana by antagonizing the effect of ethylene
  14. 1854
    “…In most p53 wild-type human cell types, radiosensitivity evaluated by the colony formation assay predominantly reflects stress-induced premature senescence (SIPS) and not cell death (Int. J. Mol. Sci. 2017, 18, 928). …”
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    Impact of Premature Senescence on Radiosensitivity Measured by High Throughput Cell-Based Assays
  15. 1855
    “…In parabiosis assays, the paracrine senescence response underlying the DCM phenotype does not transmit to healthy mice. …”
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    Bmi1 limits dilated cardiomyopathy and heart failure by inhibiting cardiac senescence
  16. 1856
    “…Suppression of Snail expression induced cellular senescence in several cancer cells and in normal fibroblast IMR90 cells. …”
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    Snail suppresses cellular senescence and promotes fibroblast‐led cancer cell invasion
  17. 1857
    “…Cellular senescence is a mechanism that virtually irreversibly suppresses the proliferative capacity of cells in response to various stress signals. …”
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    Massive reshaping of genome–nuclear lamina interactions during oncogene-induced senescence
  18. 1858
    “…In parallel, BGP also induced endothelial senescence by increasing p16 expression and the senescence‐associated β‐galactosidase (SA‐ß‐GAL) activity. …”
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    Hyperphosphatemia induces senescence in human endothelial cells by increasing endothelin‐1 production
  19. 1859
    “…Compared to wild-type mouse embryonic fibroblasts (WT-MEFs), Prx I(−/−) MEFs exhibited senescence-associated phenotypes. Moreover, the aged Prx I(−/−) mice showed an increased number of cells with senescence associated-β-galactosidase (SA-β-gal) activity in a variety of tissues. …”
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    Peroxiredoxin I participates in the protection of reactive oxygen species-mediated cellular senescence
  20. 1860
    “…Butyrate induces colonic cell senescence in part through suppression of ZBP-89 gene expression and its subsequent occupancy of the CDKN2A promoter.…”
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    ZBP-89 function in colonic stem cells and during butyrate-induced senescence
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