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  1. 1861
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    Transcriptome profiling analysis of senescent gingival fibroblasts in response to Fusobacterium nucleatum infection
  2. 1862
    “…Senescent cells are unable to form the autophagolysosomes and to remove the damaged mitochondria resulting in apoptotic death. …”
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    Targeted elimination of senescent Ras-transformed cells by suppression of MEK/ERK pathway
  3. 1863
    “…Although human mesenchymal stem cells (hMSCs) are a powerful tool for cell therapy, prolonged culture times result in replicative senescence or acquisition of tumorigenic features. To identify a molecular signature for senescence, we compared the transcriptome of senescent and young hMSCs with normal karyotype (hMSCs/n) and with a constitutional inversion of chromosome 3 (hMSC/inv). …”
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    Identification of new genes associated to senescent and tumorigenic phenotypes in mesenchymal stem cells
  4. 1864
    “…However, these reservoirs could be subjected to cellular senescence. In this review, we will discuss current progress and challenges in the understanding of different biological pathways leading to senescence. …”
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    Mesenchymal Stem Cells Secretory Responses: Senescence Messaging Secretome and Immunomodulation Perspective
  5. 1865
    “…We first characterized GALT in a mouse model of accelerated senescence (SAMP8) at different ages (compared to mice resistant to accelerated senescence; SAMR1). …”
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    Dietary Animal Plasma Proteins Improve the Intestinal Immune Response in Senescent Mice
  6. 1866
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    Autophagy controls mesenchymal stem cell properties and senescence during bone aging
  7. 1867
    “…Processes that have been linked to aging and cancer include an inflammatory milieu driven by senescent cells. Senescent cells lose the ability to divide, essentially irreversibly, and secrete numerous proteases, cytokines and growth factors, termed the senescence-associated secretory phenotype (SASP). …”
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    Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype
  8. 1868
    “…When the damage to hepatocytes is mild, the liver can regenerate itself and restore to the normal state; when the damage is irreparable, hepatocytes would undergo senescence or various forms of death including apoptosis, necrosis and necroptosis. …”
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    Senescence and cell death in chronic liver injury: roles and mechanisms underlying hepatocarcinogenesis
  9. 1869
    “…This concurrence of a pro-inflammatory status and a high miR-146a level has been associated with cellular senescence in other cell types. Hence, we assessed the three monocyte subsets for evidence of senescence, including proliferative status, telomere length, cellular ROS levels, and mitochondrial membrane potential. …”
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    The pro-inflammatory phenotype of the human non-classical monocyte subset is attributed to senescence
  10. 1870
    “…Little is known on how well senescence markers in vitro and in situ correlate within individual donors. …”
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    Do senescence markers correlate in vitro and in situ within individual human donors?
  11. 1871
    “…Cell senescence is an important driver of the ageing process. …”
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    The senescent bystander effect is caused by ROS-activated NF-κB signalling
  12. 1872
    “…Accumulating evidence indicates that the senescence-associated secretory phenotype (SASP) contributes to many aspects of physiology and disease. …”
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    Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells
  13. 1873
    “…RESULTS: MeCP2 reduced angiogenesis of senescent EPCs, promoted apoptosis, and caused senescent EPC dysfunction through SIRT1 promoter hypermethylation and histone modification. …”
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    MeCP2-mediated epigenetic regulation in senescent endothelial progenitor cells
  14. 1874
    “…There is increasing evidence that senescent cells are a driving force behind many age-related pathologies and that their selective elimination increases the life- and healthspan of mice. …”
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    Blocking negative effects of senescence in human skin fibroblasts with a plant extract
  15. 1875
    “…The events underlying senescence induced by critical telomere shortening are not fully understood. …”
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    TERRA and the histone methyltransferase Dot1 cooperate to regulate senescence in budding yeast
  16. 1876
    “…Drastic biochemical changes are observed in senescent eMVs to optimize the synthesis of reducing power. …”
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    Young and Especially Senescent Endothelial Microvesicles Produce NADPH: The Fuel for Their Antioxidant Machinery
  17. 1877
    “…Senescence-associated β-galactosidase staining was used to determine cellular senescence and reactive oxygen species (ROS) were monitored to detect the level of cell oxidative stress. …”
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    Effect of KNDC1 overexpression on the senescence of human umbilical vein endothelial cells
  18. 1878
    “…Senescent cells interact with the surrounding microenvironment achieving diverse functional outcomes. …”
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    NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence
  19. 1879
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    Dopaminergic mediation in the brain aging and neurodegenerative diseases: a role of senescent cells
  20. 1880
    “…The levels of intracellular copper were further increased in senescent MEFs cultured in copper supplemented medium and in senescent Mottled Brindled (Mo(br)) MEFs lacking functional Atp7a. …”
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    Copper accumulation in senescent cells: Interplay between copper transporters and impaired autophagy
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