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  1. 1941
    “…Previous reports have suggested a functional role for cancer-associated fibroblasts (CAFs) or senescent TC cells in the progression of PTC. In this study, we investigated the presence of CAFs and senescent cells in proprietary human TCs including PTC, PDTC, and ATC. …”
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    Cancer Associated Fibroblasts and Senescent Thyroid Cells in the Invasive Front of Thyroid Carcinoma
  2. 1942
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    The Diverse Roles of TIMP-3: Insights into Degenerative Diseases of the Senescent Retina and Brain
  3. 1943
    “…Our results demonstrate that the absence of FAP senescence after exercise leads to muscle degeneration with FAP accumulation. …”
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    Exercise enhances skeletal muscle regeneration by promoting senescence in fibro-adipogenic progenitors
  4. 1944
    “…For NK cells, it is unclear if exhaustion, anergy, and senescence entail separate and distinct entities of dysfunction, though all are typically characterized by decreased effector function or proliferation. …”
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    Characterizing the Dysfunctional NK Cell: Assessing the Clinical Relevance of Exhaustion, Anergy, and Senescence
  5. 1945
    “…Cyclic cGMP-AMP synthase (cGAS) is a pattern recognition cytosolic DNA sensor that is essential for cellular senescence. cGAS promotes inflammatory senescence-associated secretory phenotype (SASP) through recognizing cytoplasmic chromatin during senescence. cGAS-mediated inflammation is essential for the antitumor effects of immune checkpoint blockade. …”
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    Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence
  6. 1946
    “…Senescence is characterized by a stable cell cycle arrest and a complex proinflammatory secretome, termed the senescence-associated secretory phenotype (SASP). …”
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    Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence
  7. 1947
    “…Telomere shortening rates must be regulated to prevent premature replicative senescence. TERRA R‐loops become stabilized at critically short telomeres to promote their elongation through homology‐directed repair (HDR), thereby counteracting senescence onset. …”
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    Npl3 stabilizes R‐loops at telomeres to prevent accelerated replicative senescence
  8. 1948
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    PAI-1: A New Target for Controlling Lung-Cell Senescence and Fibrosis?
  9. 1949
    “…Senescent cells accumulate with age in vertebrates and promote aging largely through their senescence‐associated secretory phenotype (SASP). …”
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    Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice
  10. 1950
    “…Spontaneous senescence of cancer cells remains a puzzling and poorly understood phenomenon. …”
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    Deciphering the Molecular Mechanism of Spontaneous Senescence in Primary Epithelial Ovarian Cancer Cells
  11. 1951
    “…Lesions with driver mutations, including atypical nevi and seborrheic keratoses, are very common in dermatology, and are prone to senescence. The molecular events that prevent senescent lesions from becoming malignant are not well understood. …”
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    Establishment of a Temperature-Sensitive Model of Oncogene-Induced Senescence in Angiosarcoma Cells
  12. 1952
    “…In this study, we examined the influence of replicative senescence on the angiogenic potential of adipose-derived MSCs (ASCs). …”
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    Secretome of Senescent Adipose-Derived Mesenchymal Stem Cells Negatively Regulates Angiogenesis
  13. 1953
    “…PML inhibition led to a remarkable growth arrest combined with features of senescence in vitro and in vivo. Mechanistically, the growth arrest and senescence were associated to a decrease in MYC and PIM1 kinase levels, with the subsequent accumulation of CDKN1B (p27), a trigger of senescence. …”
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    Targeting PML in triple negative breast cancer elicits growth suppression and senescence
  14. 1954
    “…We confirmed UVB-induced senescence with increased senescence-associated β-galactosidase positivity and changed expression of several senescence markers, including p21, p53 and Lamin B1. …”
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    A new model to investigate UVB-induced cellular senescence and pigmentation in melanocytes
  15. 1955
    “…Senescent cells secrete several molecules, collectively named senescence-associated secretory phenotype (SASP). …”
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    Increase of circulating IGFBP-4 following genotoxic stress and its implication for senescence
  16. 1956
    “…Here, we show that MK2 inhibition strongly attenuated glioblastoma cell proliferation through p53(wt) stabilization and senescence. The senescence-inducing efficacy of MK2 inhibition was particularly strong when cells were co-treated with the standard-of-care temozolomide. …”
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    MK2 Inhibition Induces p53-Dependent Senescence in Glioblastoma Cells
  17. 1957
    “…Recent evidence has proven that cellular senescence contributes substantially to the development of these disorders. …”
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    Cellular Senescence as a Therapeutic Target for Age-Related Diseases: A Review
  18. 1958
    “…Using young to old‐aged human dermal fibroblasts, we observed a dysfunction of the mitotic machinery arising with age that mildly perturbs chromosome segregation fidelity and contributes to the generation of fully senescent cells. Here, we investigated mitotic mechanisms that contribute to age‐associated CIN. …”
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    Small‐molecule inhibition of aging‐associated chromosomal instability delays cellular senescence
  19. 1959
    “…While oncogene-induced senescence (OIS) driven by excessive RAS/ERK signaling has been well studied, little is known about the mechanisms underpinning the AKT-induced senescence (AIS) response. …”
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    A functional genetic screen defines the AKT-induced senescence signaling network
  20. 1960
    “…Here, we review the current knowledge of the phenotypic and functional characteristics of senescent MSCs, molecular mechanisms underlying MSCs aging, and strategies to rejuvenate senescent MSCs, which can broaden their range of therapeutic applications.…”
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    Senescence in Mesenchymal Stem Cells: Functional Alterations, Molecular Mechanisms, and Rejuvenation Strategies
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