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  1. 1961
    “…Disruption of mitochondrial homeostasis could lead to cell senescence, although the underlying mechanism remains unclear. …”
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    Mitochondrial phosphatase PGAM5 modulates cellular senescence by regulating mitochondrial dynamics
  2. 1962
    por Wang, Ziwen, Shi, Chunmeng
    Publicado 2020
    “…Recently, increasing evidence has indicated that cell senescence plays an important role in the development of chronic wounds, and preventing cell senescence or removing senescent cells holds promise as a new therapeutic strategy. …”
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    Cellular senescence is a promising target for chronic wounds: a comprehensive review
  3. 1963
    “…This study was designed to investigate the effects of SAC on primary cultured hippocampal neurons and cognitively impaired senescence-accelerated mice prone 10 (SAMP10). Treatment of these neurons with MGE or SAC significantly increased the total neurite length and number of dendrites. …”
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    Improvement of Learning and Memory in Senescence-Accelerated Mice by S-Allylcysteine in Mature Garlic Extract
  4. 1964
    “…Surprisingly, while physiological levels of androgens promote growth, supraphysiological androgen levels (SAL) inhibit PCa growth in an AR-dependent manner by inducing cell senescence in cancer cells. Thus, oppositional acting ligands, AR antagonists, and agonists are able to induce cellular senescence in PCa cells, as shown in cell culture model as well as ex vivo in patient tumor samples. …”
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    Mechanisms of Androgen Receptor Agonist- and Antagonist-Mediated Cellular Senescence in Prostate Cancer
  5. 1965
    “…Staining mice tissues for β-galactosidase activity is a fundamental tool to detect age- or disease-associated cellular senescence. However, reported analyses of positivity for senescence-associated β-galactosidase activity or for other markers of senescence in post-mitotic cells of healthy murine tissues have been fragmentary or inconclusive. …”
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    Senescence-like phenotype in post-mitotic cells of mice entering middle age
  6. 1966
    “…YPEL3 that induces cellular senescence in both normal and tumour cells of humans may show altered expression under the influence of incidental mutations. …”
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    Exploring the effect of nsSNPs in human YPEL3 gene in cellular senescence
  7. 1967
    “…BACKGROUND/OBJECTIVES: Brain senescence causes cognitive impairment and neurodegeneration. …”
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    Curcumin and hesperetin attenuate D-galactose-induced brain senescence in vitro and in vivo
  8. 1968
    “…Senescence-associated β-galactosidase (SA-β-Gal, immunohistochemistry [IHC]-staining), P16, P53, and P57 (immunoblotting) were used as markers of cell senescence. …”
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    Sunitinib facilitates metastatic breast cancer spreading by inducing endothelial cell senescence
  9. 1969
    por Poonsri, Warinthon
    Publicado 2020
    “…This research investigated the effect of different atmosphere storage conditions on 1-aminocyclopropane-1-carboxylic acid (ACC) synthase and ACC oxidase enzyme activity; and senescence of cut Dendrobium orchid flowers. The atmosphere storage conditions under study were normal atmosphere, modified atmosphere packaging, and controlled atmosphere. …”
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    Effect of modified and controlled atmosphere storage on enzyme activity and senescence of Dendrobium orchids
  10. 1970
    “…Heat shock treatments resulted in stress-induced premature senescence, affecting the MSCs’ ability to proliferate properly for many cell passages to follow. …”
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    Heat Shock Alters Mesenchymal Stem Cell Identity and Induces Premature Senescence
  11. 1971
    “…Cellular senescence plays a very important role in organismal aging increasing with age and in age-related diseases (ARDs). …”
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    Herb-Derived Products: Natural Tools to Delay and Counteract Stem Cell Senescence
  12. 1972
    “…In this study, we hypothesized that oxidative stress, due to ischemia–reperfusion, induces senescence which contributes to the pathophysiology of cardiac IRI. …”
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    Clearance of senescent cells during cardiac ischemia–reperfusion injury improves recovery
  13. 1973
    “…The recent identification of senescent cells in periodontal tissues has the potential to provide new insights into the underlying mechanisms of periodontal disease etiology. …”
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    Periodontal Disease and Senescent Cells: New Players for an Old Oral Health Problem?
  14. 1974
    “…While CBX2 overexpression occurs in a wide range of human tumors, targeted deletion results in homeotic transformation, proliferative defects, and premature senescence. However, its cellular function(s) and whether it plays a role in maintenance of genome stability remain to be determined. …”
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    Loss of CBX2 induces genome instability and senescence-associated chromosomal rearrangements
  15. 1975
    “…Surprisingly, all ten proteins are implicated in senescence-associated secreted phenotype (SASP), a hallmark of cellular senescence. …”
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    Senescence-Associated Secretory Phenotype Determines Survival and Therapeutic Response in Cervical Cancer
  16. 1976
    “…With progressing age, senescent cells accumulate in a variety of mammalian tissues, where they contribute to tissue aging, identifying cellular senescence as a major target to delay or prevent aging. …”
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    Targeting cellular senescence based on interorganelle communication, multilevel proteostasis, and metabolic control
  17. 1977
    por Hinckley, Will E., Brusslan, Judy A.
    Publicado 2020
    “…In plants, the vegetative to reproductive phase transition (termed bolting in Arabidopsis) generally precedes age‐dependent leaf senescence (LS). Many studies describe a temporal link between bolting time and LS, as plants that bolt early, senesce early, and plants that bolt late, senesce late. …”
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    Gene expression changes occurring at bolting time are associated with leaf senescence in Arabidopsis
  18. 1978
    “…Ioversol injection induced high expression levels of the mitophagy markers Pink1, Parkin, and LC3 and the senescence markers β-galactosidase and p16INK4A. Paricalcitol pretreatment prevented renal dysfunction and reduced tissue damage by reducing both mitophagy and senescence. …”
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    Paricalcitol Attenuates Contrast-Induced Acute Kidney Injury by Regulating Mitophagy and Senescence
  19. 1979
    “…Senescent cells accumulate in different organs and develop a senescence‐associated secretory phenotype (SASP), associated with the development of age‐related pathologies. …”
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    ROCK inhibition modulates the senescence‐associated secretory phenotype (SASP) in oral keratinocytes
  20. 1980
    “…Dynamic IR events have been observed in senescence models and aged tissues; however, whether and how IR impacts senescence remain unclear. …”
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    Prevalent intron retention fine‐tunes gene expression and contributes to cellular senescence
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