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  1. 29261
    “…(Consultant)MedImmune (Consultant, Grant/Research Support)Merck (Grant/Research Support)NIH (Grant/Research Support)Novadigm (Consultant)Novartis (Consultant, Grant/Research Support)Pfizer (Grant/Research Support)Regeneron (Consultant, Grant/Research Support)sepsis diagnostics (Other Financial or Material Support, Pending patent for host gene expression signature diagnostic for sepsis.)Tetraphase (Consultant)Theravance (Consultant, Grant/Research Support, Other Financial or Material Support, Educational fees)Trius (Consultant)UpToDate (Other Financial or Material Support, Royalties)Valanbio (Consultant, Other Financial or Material Support, Stock options)xBiotech (Consultant) Daniel D. …”
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    133. ARGONAUT-III: Susceptibility of Carbapenem-resistant Klebsiellae to Cefepime-Taniborbactam
  2. 29262
    “…(Consultant)MedImmune (Consultant, Grant/Research Support)Merck (Grant/Research Support)NIH (Grant/Research Support)Novadigm (Consultant)Novartis (Consultant, Grant/Research Support)Pfizer (Grant/Research Support)Regeneron (Consultant, Grant/Research Support)sepsis diagnostics (Other Financial or Material Support, Pending patent for host gene expression signature diagnostic for sepsis.)Tetraphase (Consultant)Theravance (Consultant, Grant/Research Support, Other Financial or Material Support, Educational fees)Trius (Consultant)UpToDate (Other Financial or Material Support, Royalties)Valanbio (Consultant, Other Financial or Material Support, Stock options)xBiotech (Consultant) Daniel D. …”
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    1055. ARGONAUT-IV: Susceptibility of Carbapenem-resistant Klebsiellae to Ceftibuten/VNRX-5236
  3. 29263
    “…Univariate analysis showed that the amblyopia risk group had lower birth weights, higher rates of asphyxia, preterm brain white matter injury, bronchopulmonary dysplasia (BPD), intraventricular hemorrhage (IVH), sepsis during hospitalization, and higher rates of treatment with pulmonary surfactant (PS), blood transfusion, invasive ventilator, and levothyroxine. …”
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    Analysis of risk factors associated with the high incidence of amblyopia in preterm infants at the corrected gestational age of 12 months
  4. 29264
    “…If left untreated, infection can lead to serious morbidity including infertility, sepsis and increased risk of HIV acquisition. Development of a gonorrhoea vaccine has been challenging, however there is observational evidence that serogroup B meningococcal vaccines, used to protect against the closely related bacteria Neisseria meningitidis, could provide cross-protection against N. gonorrhoeae. …”
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    An open-label randomised controlled trial evaluating the efficacy of a meningococcal serogroup B (4CMenB) vaccine on Neisseria gonorrhoeae infection in gay and bisexual men: the MenGO study protocol
  5. 29265
    “…BACKGROUND: Mid-regional pro-adrenomedullin (MR-proADM), an endothelium-related peptide, is a predictor of death and multi-organ failure in respiratory infections and sepsis and seems to be effective in identifying COVID-19 severe forms. …”
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    Effectiveness of mid-regional pro-adrenomedullin, compared to other biomarkers (including lymphocyte subpopulations and immunoglobulins), as a prognostic biomarker in COVID-19 critically ill patients: New evidence from a 15-month observational prospective study
  6. 29266
    “…Survival analyses showed that 27 out of 30 patients survived, while three patients died at ages of 28, 39, and 46 years as a consequence of lung bleeding, lymphoma, and sepsis, respectively. Analysis of a cumulative follow-up period of 278.7 patient-years showed that early diagnosis, adequate management at expertise centers for IEI, prophylactic antibiotics, and antifungal therapy improve outcomes and can positively influence the life expectancy of patients. …”
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    Long term longitudinal follow-up of an AD-HIES cohort: the impact of early diagnosis and enrollment to IPINet centers on the natural history of Job’s syndrome
  7. 29267
    “…CONCLUSIONS: The transcriptomic score provides a useful and reliable companion diagnostic tool to further develop immune modulating drugs in sepsis in the context of personalized medicine. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13054-023-04436-3.…”
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    Identification of a sub-group of critically ill patients with high risk of intensive care unit-acquired infections and poor clinical course using a transcriptomic score
  8. 29268
    “…All-cause mortality was mainly driven by patients succumbing to CIED-related sepsis, despite successful extraction. Chronic kidney disease and lead age ≥10 years are relevant risk factors in young patients undergoing TLE.…”
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    Procedural outcome and risk prediction in young patients undergoing transvenous lead extraction. A GALLERY subgroup analysis
  9. 29269
    “…The invasive infections of MRSA occurred at a median age of 8 days on admission, which was significantly younger compared to 19 days in noninvasive cases. Sepsis (86.6%) was the most common invasive infection, followed by pneumonia (7.4%), bone and joint infections (3.0%), central nervous system infection (1.5%), and peritonitis (1.5%). …”
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    Clinical characteristics and antibiotic resistance profile of invasive MRSA infections in newborn inpatients: a retrospective multicenter study from China
  10. 29270
    “…Complications seen were acute respiratory distress syndrome (2, 14.3%), sepsis with multiorgan failure (2, 14.3%) and ventilator-associated pneumonia (1, 7.1%). …”
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    A Profile Study of Japanese Encephalitis in an Industrial Hospital in Eastern India
  11. 29271
    “…Studies comparing early vs late-initiated KMC demonstrated a reduction in neonatal mortality (RR 0.77, 95% CI 0.66 to 0.91; three trials, 3693 infants; high certainty evidence) and a probable decrease in clinical sepsis until 28-days (RR 0.85, 95% CI 0.76 to 0.96; two trials; low certainty evidence) following early initiation of KMC. …”
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    Kangaroo mother care for preterm or low birth weight infants: a systematic review and meta-analysis
  12. 29272
    por Ahuja, Sunil K., Manoharan, Muthu Saravanan, Lee, Grace C., McKinnon, Lyle R., Meunier, Justin A., Steri, Maristella, Harper, Nathan, Fiorillo, Edoardo, Smith, Alisha M., Restrepo, Marcos I., Branum, Anne P., Bottomley, Matthew J., Orrù, Valeria, Jimenez, Fabio, Carrillo, Andrew, Pandranki, Lavanya, Winter, Caitlyn A., Winter, Lauryn A., Gaitan, Alvaro A., Moreira, Alvaro G., Walter, Elizabeth A., Silvestri, Guido, King, Christopher L., Zheng, Yong-Tang, Zheng, Hong-Yi, Kimani, Joshua, Blake Ball, T., Plummer, Francis A., Fowke, Keith R., Harden, Paul N., Wood, Kathryn J., Ferris, Martin T., Lund, Jennifer M., Heise, Mark T., Garrett, Nigel, Canady, Kristen R., Abdool Karim, Salim S., Little, Susan J., Gianella, Sara, Smith, Davey M., Letendre, Scott, Richman, Douglas D., Cucca, Francesco, Trinh, Hanh, Sanchez-Reilly, Sandra, Hecht, Joan M., Cadena Zuluaga, Jose A., Anzueto, Antonio, Pugh, Jacqueline A., Agan, Brian K., Root-Bernstein, Robert, Clark, Robert A., Okulicz, Jason F., He, Weijing
    Publicado 2023
    “…With this resistance, preservation of optimal IR tracked (i) a lower risk of HIV acquisition, AIDS development, symptomatic influenza infection, and recurrent skin cancer; (ii) survival during COVID-19 and sepsis; and (iii) longevity. IR degradation is potentially reversible by decreasing inflammatory stress. …”
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    Immune resilience despite inflammatory stress promotes longevity and favorable health outcomes including resistance to infection
  13. 29273
    “…Furthermore, the efficacy of cefiderocol was investigated in the randomized, open-label, pathogen-focused, descriptive CREDIBLE–CR Phase 3 clinical study in its target patient population with serious carbapenem-resistant Gram-negative infections, including hospitalized patients with nosocomial pneumonia, bloodstream infection/sepsis, or complicated urinary tract infections. However, a numerically greater ACM rate with cefiderocol compared with BAT led to the inclusion of a warning in US and European prescribing information. …”
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    Treatment of critically ill patients with cefiderocol for infections caused by multidrug-resistant pathogens: review of the evidence
  14. 29274
    “…CONCLUSIONS: In conclusion, we established an accurate pulmonary sepsis-induced ARDS model. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13054-023-04512-8.…”
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    A long-lasting porcine model of ARDS caused by pneumonia and ventilator-induced lung injury
  15. 29275
    “…Post-stroke complications were significantly more common in the UTI group, including pneumonia, respiratory failure, sepsis, brain edema, seizure, symptomatic hemorrhagic transformation, congestive heart failure, atrial fibrillation with a rapid ventricular response, acute kidney injury, and hyponatremia. …”
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    Determinants of urinary tract infection in hospitalized patients with acute ischemic stroke
  16. 29276
    Publicado 2023
    “…BACKGROUND: Hospitalisation and a seven-day injectable antibiotics course are recommended by the World Health Organization (WHO) to treat suspected clinical neonatal sepsis / possible serious bacterial infection (PSBI). …”
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    How long should young infants less than two months of age with moderate-mortality-risk signs of possible serious bacterial infection be hospitalised for? Study protocol for a randomised controlled trial from low- and middle-income countries
  17. 29277
    “…BACKGROUND: Presepsin is an emerging biomarker in the diagnosis of sepsis. In the field of orthopaedics, it could be useful in diagnosing and managing periprosthetic joint infections. …”
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    Physiologic postoperative presepsin kinetics following primary cementless total hip arthroplasty: A prospective observational study
  18. 29278
    “…BACKGROUND: Sepsis‐induced intensive care unit‐acquired weakness (ICUAW) features profound muscle atrophy and attenuated muscle regeneration related to malfunctioning satellite cells. …”
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    SPSB1‐mediated inhibition of TGF‐β receptor‐II impairs myogenesis in inflammation
  19. 29279
    “…The SII has been shown to have prognostic value in various clinical settings, including critical illness, sepsis, and cancer. Its role in chronic obstructive pulmonary disease (COPD) remains unclear and requires further investigation. …”
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    Association between systemic immune-inflammation index and chronic obstructive pulmonary disease: a population-based study
  20. 29280
    “…When monocytes were challenged with LPS, IL-2, and IFN-γ to simulate sepsis, monocytes that had efferocytosed viable MSC had higher levels of IDO while monocytes that efferocytosed heat inactivated-MSCs produced the lowest levels of TNF-α. …”
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    Efferocytosis of viable versus heat-inactivated MSC induces human monocytes to distinct immunosuppressive phenotypes
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