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  1. 29741
    “…Fifty (28%) pts experienced COVID-19 complications, the most common were pneumonia in 125 (71%) pts, respiratory failure in 82(47%) pts, ARDS in 11(6%) pts, cytokine release syndrome in 15(9%) pts, multiple organ failure in 10(6%) pts, sepsis in 6(3%) pts, and pulmonary bleeding in 1(0,6%). …”
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    Outcomes in Patients with Hematologic Disease and COVID-19 in Russia: Interim Analysis of CHRONOS19 Registry
  2. 29742
    por Gor, Shivani, Carty, Sara
    Publicado 2022
    “…Given our patient’s age, and absence of both clinical and biochemical features of sepsis meant that PAN seemed a more likely explanation. …”
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    OA18 A rare presentation of Polyarteritis Nodosa
  3. 29743
    “…BACKGROUND: Annually, infections contribute to approximately 25% of the 2.8 million neonatal deaths worldwide. Over 95% of sepsis‐related neonatal deaths occur in low‐ and middle‐income countries. …”
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    Hand hygiene for the prevention of infections in neonates
  4. 29744
    “…Due to recurrent infections (warranting multiple admissions to the ITU for respiratory/ionotropic support for severe sepsis), cyclophosphamide was suspended after 2 doses. …”
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    OA14 The role of anifrolumab in treating life threatening systemic lupus erythematosus with severe mucocutaneous involvement
  5. 29745
    “…Fowler, MD, MHS, Amphliphi Biosciences, Integrated Biotherapeutics; C3J, Armata, Valanbio; Akagera, Aridis, Roche, Astra Zeneca: Advisor/Consultant|Genentech, Regeneron, Deep Blue, Basilea, Janssen;: Grant/Research Support|Infectious Diseases Society of America: Honoraria|MedImmune, Allergan, Pfizer, Advanced Liquid Logics, Theravance, Novartis, Merck; Medical Biosurfaces; Locus; Affinergy; Contrafect; Karius;: Grant/Research Support|Novartis, Debiopharm, Genentech, Achaogen, Affinium, Medicines Co., MedImmune, Bayer, Basilea, Affinergy, Janssen, Contrafect, Regeneron, Destiny,: Advisor/Consultant|Sepsis diagnostic: Patent pending|UpToDate: Royalties|Valanbio and ArcBio: Stock Options David van Duin, MD, PhD, Entasis: Advisor/Consultant|Merck: Advisor/Consultant|Merck: Grant/Research Support|Pfizer: Advisor/Consultant|Pfizer: Honoraria|Qpex: Advisor/Consultant|Roche: Advisor/Consultant|Shionogi: Advisor/Consultant|Shionogi: Grant/Research Support|Union: Advisor/Consultant|Utility: Advisor/Consultant…”
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    215. Shorter vs. Longer Duration of Treatment in Patients with Ceftriaxone-resistant and Ceftriaxone-susceptible Escherichia coli Bloodstream Infections
  6. 29746
    “…It was already demonstrated by Esteban et al., in a prospective study that patients with severe sepsis had a mortality rate of 26% when not admitted to an ICU in comparison to 11% when they were admitted to an ICU.(8) Meanwhile, we know that early referral is particularly important, because for ischemic diseases the timing appears to make a difference in terms of full recovery. …”
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    Surgical intensive care – current and future challenges?
  7. 29747
    “…Absolute platelet count below 50,000 cells/mm(3) e. Documented sepsis or high suspicion of superimposed infection by pathogens other than COVID-19. f. …”
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    Subcutaneous Sarilumab in hospitalised patients with moderate-severe COVID-19 infection compared to the standard of care (SARCOVID): a structured summary of a study protocol for a randomised controlled trial
  8. 29748
    “…Exclusion criteria: high oxygen requirements (including face mask with reservoir, non-invasive mechanical ventilation or high flow nasal cannula, or mechanical ventilation), admission to ICU, pregnancy or lactation, allergy or hypersensitivity to sarilumab or corticoesteroids, immunosuppressive antibody therapy within the past 5 months, AST/ALT values > 10 x ULN, neutropenia (< 0.5 x 109/L), severe thrombocytopenia (< 50 x 109/L), sepsis caused by an alternative pathogen, diverticulitis with risk of perforation or ongoing infectious dermatitis. …”
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    Sarilumab versus standard of care for the early treatment of COVID-19 pneumonia in hospitalized patients: SARTRE: a structured summary of a study protocol for a randomised controlled trial
  9. 29749
    “…However, ongoing research is required to examine the safety (and benefit) of early immunomodulation use when other differentials (including sepsis and malignancy) have not been fully or reliably excluded. …”
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    O16 Learning from acute COVID-19in a patient with potential immune dysregulation
  10. 29750
    “…Results:In experimental ARDS, sepsis, and endotoxin-induced lung injury, GLN decreases consolidation, pulmonary edema, and neutrophil infiltration and increases lung compliance, oxygen saturation, heat shock protein activation, and survival by 2.5-fold over saline controls (Perng WC, Clin Exp Pharmacol Physiol, 2010; Singleton, Crit Care Med, 2005). …”
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    Actions of L-Glutamine vs. COVID-19 Suggest Additional Benefit in Sickle Cell Disease
  11. 29751
    “…Background: The clinical spectrum of COVID-19 ranges from pauci-symptomatic forms to severe disease characterized by respiratory failure requiring mechanical ventilation and intensive care unit (ICU) management, as well as multisystem involvement characterized by sepsis, organ dysfunction and death. Treatment of COVID-19 is not standardized, and respiratory failure from ARDS is the leading cause of mortality; in-hospital mortality at 28-days in our tertiary care center in Lombardia, northern Italy was 23% during the first wave in 2020(Ciceri et al. 2020). …”
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    Use of Defibrotide in Patients with COVID-19 Pneumonia; Results of the Defi-VID19 Phase 2 Trial
  12. 29752
    “…One patient in treatment group 2 died of sepsis after the first cycle of OEPA; no other treatment-related deaths occurred. …”
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    Response-adapted omission of radiotherapy and comparison of consolidation chemotherapy in children and adolescents with intermediate-stage and advanced-stage classical Hodgkin lymphoma (EuroNet-PHL-C1): a titration study with an open-label, embedded, multinational, non-inferiority, randomised controlled trial
  13. 29753
    “…Initial COVID-19 swabs were negative as was extensive investigation for other sepsis triggers. A high clinical suspicion of COVID-19 led to the second positive swab and early recognition of sHLH. …”
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    O01 Adult onset PIMS-TS with secondary haemophagocytic lymphistiocytosis: into the eye of the cytokine storm
  14. 29754
    “…Fowler, MD, MHS, Amphliphi Biosciences, Integrated Biotherapeutics; C3J, Armata, Valanbio; Akagera, Aridis, Roche, Astra Zeneca: Advisor/Consultant|Genentech, Regeneron, Deep Blue, Basilea, Janssen;: Grant/Research Support|Infectious Diseases Society of America: Honoraria|MedImmune, Allergan, Pfizer, Advanced Liquid Logics, Theravance, Novartis, Merck; Medical Biosurfaces; Locus; Affinergy; Contrafect; Karius;: Grant/Research Support|Novartis, Debiopharm, Genentech, Achaogen, Affinium, Medicines Co., MedImmune, Bayer, Basilea, Affinergy, Janssen, Contrafect, Regeneron, Destiny,: Advisor/Consultant|Sepsis diagnostic: Patent pending|UpToDate: Royalties|Valanbio and ArcBio: Stock Options Thomas L. …”
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    870. Plasma microbial cell-free DNA sequencing impacts antimicrobial management in immunocompromised patients with pneumonia
  15. 29755
    “…The topics of the abstracts published in this special issue of QMJ cover dietetics,(8) sepsis,(9) delirium,(10,11) physical therapy,(12) end of life care and organ donation,(13,14) dealing with families,(15) as well as education and training of clinicians,(16,17) to only highlight a few. …”
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    The inaugural Qatar Critical Care Conference with its Qatar Medical Journal Special Issue – An important milestone
  16. 29756
    “…D-dimer >4 times the upper level of normal reference range. b. Sepsis-Induced Coagulopathy (SIC) score >4. 5. No need of IMV. …”
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    Randomised controlled trial comparing efficacy and safety of high versus low Low-Molecular Weight Heparin dosages in hospitalized patients with severe COVID-19 pneumonia and coagulopathy not requiring invasive mechanical ventilation (COVID-19 HD): a structured summary of a study protocol
  17. 29757
    “…The use of tocilizumab is not recommended if there are AST/ALT values greater than 10 times the upper limit of normal, neutrophils <500 cells/mm3, sepsis due to other pathogens other than SARS-CoV-2, presence of comorbidity that can lead to a poor prognosis, complicated diverticulitis or intestinal perforation, ongoing skin infection. …”
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    A Phase I/II Clinical Trial to evaluate the efficacy of baricitinib to prevent respiratory insufficiency progression in onco-hematological patients affected with COVID19: A structured summary of a study protocol for a randomised controlled trial
  18. 29758
    por Sweeney, Yvonne, O’Neill, Hugh, Duffy, Garry, Creegan, Daniel, Bustos, Viviana, Harvey, Brian J., Dalphy, Alexander, O’Grady, Anthony, Kay, Elaine, Samelska, Katarzyna, Izdebska, Justyna, Kurowska, Anna, Al-Zubaidy, Rena, Mroz, Magdalena, Harvey, Brian, Fagan, Ryan, French, Helen, Cuddy, Vanessa, Ashton, Jennifer, Clarke, Michelle, Sayedalamin, Zaid, Baig, Mukhtiar, Almutairi, Osama, Allam, Hassan, Halawa, Taher F., Atta, Hazem M., Sirone, Linda, Erts, Renars, Pavare, Jana, Richter, Louis, Morris, Joseph, Oglesby, Irene, Dunne, Eimear, Kenny, Dermot, Khayyat, Ibrahim Mohammed Mahdi, Salgado, Viviana Bustos, Harvey, Brian J., Tan, Jonavan, Moneley, Daragh, Leahy, Austin, Fitzgerald, Patricia, Fennelly, Evelyn, Harkin, Grace, Lee, John, O’Sullivan, Erica, Kirby, Brian, O’Neill, Sarah, Gonciar, Diana, Mocan, Teodora, Matea, Cristian, Mocan, Lucian, Iancu, Cornel, Doran, Chloe, Hoolahan, Sarah, Engel, Tobias, Alkhattab, Maha, Alekseeva, Tijna, Lackington, William, O’Brien, Fergal, Moollan, Nabeehah, Doran, Chloe, McElvaney, Noel Gerry, Gunaratnam, Cedric, Scanlon, Lorraine, Brady, Noeleen, Timmons, Suzanne, Bresler, Richard, Abreu, Zita, Trohonel, Stefan, Bargman, Joanne, Mirza, Ahmad A., Badrek-Amoudi, Ahmed, Aun, Rakan H., Senan, Hussam A., Mirza, Abdulrahim A., Binsaad, Mohammed S., Farooq, Mian U., Nandi, Saheli, D’Orsi, Beatrice, Prehn, Jochen, Zharova, Mariia, Umrukhin, Pavel, Evans-Uhegbu, Wendy, Doyle, Frank, Kudryashova, Hope, Dorris, Derek, Cummins, Anthony, Doheny-Shanley, Jemma, Woodward, Mark, Hayes, Wesley, Yostos, Marina, Cotter, David, Focking, Melanie, Stancu, Samantha, Iordache, Florin, Popescu, Bogdan A., Akanmu, Muhammad-Mujtaba A., Robert, Alero A., Oridota, Ezekiel O., Mirza, Ahmad A., Alzahrani, Ali K., Alfarhan, Omar, Eldin, Essam Nour, MacManus, Bronagh, Keane, Owen, Hillery, Patrick, Lee, James, O’Reilly, Hugh, Collins, Niamh, Abu saq, Ibrahim, Al Mufarrih, Abdullah, Jaafari, Muath, Al Mahayni, Abdullah, Bawazir, Amen, Alkhateeb, Sultan, Dhannoon, Amenah, Vareslija, Damir, Hill, Arnold, Young, Leonie, Donoghue, Declan, Walsh, Criona, McCabe, Aileen, Pope, John, Pasco, Saturnino, Fallon, Caroline, Solanki, Don, Kiernan, Fiona, Galvin, Sinead, Mucvimicc, Jquan, Mulvihill, Johanna, Mirza, Ahmad A., Elmosry, Soha A., De Souza, Lorenza Andres Ameida, de Oliveira, Yuri, Menezes, Diego, Santos, Alene Vanessa, Asraf, Ahmad Zaki, Stallings, Raymond, Piskareva, Olga, Conlon, Ross, Sweeney-Landers, Siún, Burke, Cathy, Behan, Paraic, Sreenan, Seamus, Organjee, Ahmed, Crosbie-Staunton, Tatsiana, Reeves, Emer, McElvaney, Noel, Mieres, Crystal, Young, Leonie, Charmsaz, Sara, Al-Jalamdeh, Aya, Corcoran, Mary, McElligott, Martha, Stevens, Niall, Humphreys, Hilary, Barnawi, Rashid, Ghurab, Abdulaziz, Alfaer, Sultan, Balubaid, Hassan, Hanbazazah, Kamal, Bukhari, Mohammed, Alsakkaf, Mohammed, Mirza, Ahmad, Mohammed, Amrallah, Pratanata, Anastasia, Nathania, Maria, Annisa, Tsabita, Dewi, Beti, Lee, Kuok Zhen, Carroll, Tomas P., Fee, Laura, McElvaney, Noel G., White, Rachel C., Brady, Robert T, O’Brien, Fergal
    Publicado 2016
    “…Atta P2: Positive fluid balance as a prognostic factor in children with sepsis during first 3 hours of resuscitation in intensive care unit Linda Sirone, Renars Erts, Jana Pavare P3: Patients on aspirin: Too little or too much? …”
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    Abstracts from the 5th International Conference for Healthcare and Medical Students (ICHAMS): Dublin, Ireland. 19-20 February 2016
  19. 29759
    “…Most common Treatment-Emergent AEs of Grade ≥3 regardless of causality were neutropenia in 51.5%, thrombocytopenia in 50%, anemia in 40%, febrile neutropenia in 26%, leukopenia in 21%, pneumonia in 12%, and sepsis in 7% of patients treated with oral decitabine/cedazuridine (excluding the IV decitabine cycle). …”
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    Clinical Efficacy and Safety of Oral Decitabine/Cedazuridine in 133 Patients with Myelodysplastic Syndromes (MDS) and Chronic Myelomonocytic Leukemia (CMML)
  20. 29760
    por Levy, Zachary David
    Publicado 2017
    “…A 78-year-old male is in the ICU recovering from sepsis and pneumonia. He was just recently extubated after 2 days of mechanical ventilation and sedation with a fentanyl infusion. …”
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    Exam 4 Questions
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